A statistical analysis of selected freight commodities terminated by New England Class I railroads, 1931-1950

Thesis (M.B.A.)--Boston Universit

The use of the generalized inverse in the general linear statistical model

The general linear model of statistical inference is formulated in terms of the Moore-Penrose generalized inverse. The matrix algebra of the generalized inverse which is essential to the model is presented. A methodology for estimation and hypothesis testing is derived which permits identical manipulation of both the full rank and the less-than-full rank cases of the model.http://www.archive.org/details/useofgeneralized00acklLieutenant, United States NavyApproved for public release; distribution is unlimited

Effect Of Coronary Bypass And Valve Structure On Outcome In Isolated Valve Replacement For Aortic Stenosis

Reports differ regarding the effect of concomitant coronary artery bypass grafting (CABG) in patients who undergo aortic valve replacement (AVR) for aortic stenosis (AS), and no reports have described the effect of aortic valve structure in patients who undergo AVR for AS. A total of 871 patients aged 24 to 94 years (mean 70) whose AVR for AS was their first cardiac operation, with or without first concomitant CABG, were included. Patients who underwent mitral valve procedures were excluded. In comparison with the 443 patients (51%) who did not undergo CABG, the 428 (49%) who underwent concomitant CABG were significantly older, were more often male, had lower transvalvular peak systolic pressure gradients and larger valve areas, had lower frequencies of congenitally malformed aortic valves, had lighter valves by weight, had higher frequencies of systemic hypertension, and had longer stays in the hospital after AVR. Early and late (to 10 years) mortality were similar by propensity-adjusted analysis in patients who did and did not undergo concomitant CABG. Congenitally unicuspid or bicuspid valves occurred in approximately 90% of those aged 21 to 50, in nearly 70% in those aged 51 to 70 years, and in just over 30% in those aged 71 to 95 years. Unadjusted and adjusted survival was significantly higher in patients with unicuspid or bicuspid valves compared to those with tricuspid valves. In conclusion, although concomitant CABG had no effect on the adjusted probability of survival, the type of aortic valve (unicuspid or bicuspid vs tricuspid) significantly affected the unadjusted and adjusted probability of survival. (C) 2012 Elsevier Inc. All rights reserved. (Am J Cardiol 2012;109:1334-1340)Statistic

Presence Of A Congenitally Bicuspid Aortic Valve Among Patients Having Combined Mitral And Aortic Valve Replacement

Although bicuspid aortic valve occurs in an estimated 1% of adults and mitral valve prolapse in an estimated 5% of adults, occurrence of the 2 in the same patient is infrequent. During examination of operatively excised aortic and mitral valves because of dysfunction (stenosis and/or regurgitation), we encountered 16 patients who had congenitally bicuspid aortic valves associated with various types of dysfunctioning mitral valves. Eleven of the 16 patients had aortic stenosis (AS): 5 of them also had mitral stenosis, of rheumatic origin in 4 and secondary to mitral annular calcium in 1; the other 6 with aortic stenosis had pure mitral regurgitation (MR) secondary to mitral valve prolapse in 3, to ischemia in 2, and to unclear origin in 1. Of the 5 patients with pure aortic regurgitation, each also had pure mitral regurgitation: in 1 secondary to mitral valve prolapse and in 4 secondary to infective endocarditis. In conclusion, various types of mitral dysfunction severe enough to warrant mitral valve replacement occur in patients with bicuspid aortic valves. A proper search for mitral valve dysfunction in patients with bicuspid aortic valves appears warranted. (C) 2012 Elsevier Inc. All rights reserved. (Am J Cardiol 2012;109:263-271)Integrative Biolog

From usability to secure computing and back again

Secure multi-party computation (MPC) allows multiple parties to jointly compute the output of a function while preserving the privacy of any individual party’s inputs to that function. As MPC protocols transition from research prototypes to realworld applications, the usability of MPC-enabled applications is increasingly critical to their successful deployment and widespread adoption. Our Web-MPC platform, designed with a focus on usability, has been deployed for privacy-preserving data aggregation initiatives with the City of Boston and the Greater Boston Chamber of Commerce. After building and deploying an initial version of the platform, we conducted a heuristic evaluation to identify usability improvements and implemented corresponding application enhancements. However, it is difficult to gauge the effectiveness of these changes within the context of real-world deployments using traditional web analytics tools without compromising the security guarantees of the platform. This work consists of two contributions that address this challenge: (1) the Web-MPC platform has been extended with the capability to collect web analytics using existing MPC protocols, and (2) as a test of this feature and a way to inform future work, this capability has been leveraged to conduct a usability study comparing the two versions ofWeb-MPC. While many efforts have focused on ways to enhance the usability of privacy-preserving technologies, this study serves as a model for using a privacy-preserving data-driven approach to evaluate and enhance the usability of privacy-preserving websites and applications deployed in realworld scenarios. Data collected in this study yields insights into the relationship between usability and security; these can help inform future implementations of MPC solutions.Published versio

Infrared Behaviour of Propagators and Vertices

We elucidate constraints imposed by confinement and dynamical chiral symmetry breaking on the infrared behaviour of the dressed-quark and -gluon propagators, and dressed-quark-gluon vertex. In covariant gauges the dressing of the gluon propagator is completely specified by P(k^2):= 1/[1+Pi(k^2)], where Pi(k^2) is the vacuum polarisation. In the absence of particle-like singularities in the dressed-quark-gluon vertex, extant proposals for the dressed-gluon propagator that manifest P(k^2=0)=0 and Max[P(k^2)]~10 neither confine quarks nor break chiral symmetry dynamically. This class includes all existing estimates of P(k^2) via numerical simulations.Comment: 10 pages, 2 figure

Costly choices for treating Wilson's disease

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110871/1/hep27663.pd

Percutaneous Thrombin Injection for Treatment of a Splenic Artery Aneurysm

AbstractSplenic artery aneurysms are an uncommon entity and are usually asymptomatic when diagnosed. Treatment is based on size, with aneurysms greater than 2 cm usually undergoing surgical repair. We present a case in which percutaneous thrombin injection was used for treatment of a splenic artery aneurysm

Intramolecular interactions of the regulatory domains of the Bcr–Abl kinase reveal a novel control mechanism

AbstractBackground The Abl nonreceptor tyrosine kinase is implicated in a range of cellular processes and its transforming variants are involved in human leukemias. The N-terminal regulatory region of the Abl protein contains Src homology domains SH2 and SH3 which have been shown to be important for the regulation of its activity in vivo. These domains are often found together in the same protein and biochemical data suggest that the functions of one domain can be influenced by the other.Results We have determined the crystal structure of the Abl regulatory region containing the SH3 and SH2 domains. In general, the individual domains are very similar to those of previously solved structures, although the Abl SH2 domain contains a loop which is extended so that one side of the resulting phosphotyrosine-binding pocket is open. In our structure the protein exists as a monomer with no intermolecular contacts to which a biological function may be attributed. However, there is a significant intramolecular contact between a loop of the SH3 domain and the extended loop of the SH2 domain. This contact surface includes the SH2 loop segment that is responsible for binding the phosphate moiety of phosphotyrosine-containing proteins and is therefore critical for orienting peptide interactions.Conclusions The crystal structure of the composite Abl SH3–SH2 domain provides the first indication of how SH2 and SH3 domains communicate with each other within the same molecule and why the presence of one directly influences the activity of the other. This is the first clear evidence that these two domains are in contact with each other. The results suggest that this direct interaction between the two domains may affect the ligand binding properties of the SH2 domain, thus providing an explanation for biochemical and functional data concerning the Bcr–Abl kinase