Fault slip-rate variations during crustal-scale strain localisation, central Italy

Rates of plate motion are generally uniform over 10–102 Myrs timescales. Faults between tectonic plates might, therefore, be expected to show temporally-uniform slip-rates if the same number of faults remain active. For an extending region of the Eurasia-Africa plate boundary, Italy, finite throw values (vertical component of the slip) for seismogenic normal faults are less than that predicted when recent throw-rates are extrapolated over the fault lifetimes. The effect correlates with distance from the fault system tips and demonstrates that the slip-rates on centrally-located faults have increased with time. Neighbouring normal faults were active in the Quaternary but show no signs of surface faulting during the latest Pleistocene to Holocene. Death of these faults has provided the extra strain per unit time to drive the increased slip-rates measured on other faults. Thus, fault interaction and death modify slip-rates and seismic hazards associated with plate tectonics

The physiological expression of inducible nitric oxide synthase (iNOS) in the human colon

Inducible nitric oxide synthase (iNOS) is expressed in the colonic epithelium in both inflammatory bowel disease and colorectal cancer. Nitric oxide (NO), the product of this enzyme, has been implicated in the pathogenesis of both conditions. However, there are conflicting data on whether iNOS is expressed in the normal, uninflamed human colon. To evaluate the expression of iNOS in histologically normal, non-inflamed human colonic mucosa. Reverse transcription polymerase chain reaction (RT-PCR), immunoblotting, and immunohistochemistry were used to investigate the expression of iNOS in 17 histologically normal specimens obtained at colectomy performed for colorectal neoplasia. In addition, 16 endoscopic mucosal biopsies, taken from normal individuals, were also evaluated. Eleven surgical specimens and 16 endoscopic biopsies from patients with refractory ulcerative colitis were used as inflammatory controls. All types of specimens expressed iNOS mRNA. Immunoblotting revealed a protein of approximately 130 kDa consistent with iNOS in mucosal extracts of 77% of normal individuals, and 85% of diseased controls. Immunolabelling localised this protein to the surface epithelium in most of the normal specimens and also to the crypt epithelium and inflammatory cells in the diseased controls. These findings provide evidence that iNOS is often expressed in the surface epithelium of non-inflamed human colon, suggesting that it is induced by local luminal factors, such as bacterial lipopolysaccharide (endotoxin). The resultant NO produced at this site might act as an oxidative barrier, reducing bacterial translocation and providing a means of defence against pathogenic microorganisms

Uncertainty in strain-rate from field measurements of the geometry, rates and kinematics of active normal faults: Implications for seismic hazard assessment

Multiple measurements of the geometry, kinematics and rates of slip across the Auletta fault (Campania, Italy) are presented, and we use these to determine: (1) the spatial resolution of field measurements needed to accurately calculate a representative strain-rate; (2) what aspects of the geometry and kinematics would introduce uncertainty with regard to the strain-rate if not measured in the field. We find that the magnitude of the post last-glacial maximum throw across the fault varies along strike. If such variations are unnoticed, different values for a representative strain-rate, hence different results in seismic hazard calculations, would be produced. To demonstrate this, we progressively degrade our dataset, calculating the implied strain-rate at each step. Excluding measurements can alter strain-rate results beyond 1σ uncertainty, thus we urge caution when using only one measurement of slip-rate for calculating hazard. We investigate the effect of approximating the throw profile along the fault with boxcar and triangular distributions and show that this can underestimate or overestimate the strain-rate, with results in the range of 72–237% of our most detailed strain-rate calculation. We discuss how improved understanding of the potential implied errors in strain-rate calculations from field structural data should be implemented in seismic hazard calculations

Stress loading history of earthquake faults influenced by fault/shear zone geometry and Coulomb pre-stress

Whether the stress-loading of faults to failure in earthquakes appears to be random or to an extent explainable, given constraints on fault/shear-zone interaction and the build-up and release of stress over many earthquake cycles, is a key question for seismic hazard assessment. Here we investigate earthquake recurrence for a system of 25 active normal faults arranged predominantly along strike from each other, allowing us to isolate the effects of stress-loading due to regional strain versus across- and along-strike fault interaction. We calculate stress changes over 6 centuries due to interseismic loading and 25 > Mw 5.5 earthquakes. Where only one fault exists across strike, stress-loading is dominated by the regional tectonics through slip on underlying shear zones and fault planes have spatially smooth stress with predominantly time-dependent stress increase. Conversely, where faults are stress-loaded by across-strike fault interactions, fault planes have more irregular stress patterns and interaction-influenced stress loading histories. Stress-loading to failure in earthquakes is not the same for all faults and is dependent on the geometry of the fault/shear-zone system

Governing and commercialising early childhood education: Profiting from The International Early Learning and Well-being Study (IELS)

This article examines why the government in England has signed the country up to taking part in the OECD’s new international assessment known as The International Early Learning and Well-being Study (IELS). The article highlights the role of IELS as a technology of neoliberal governance. Looking forward it considers how IELS may open up new business opportunities and spaces for profit for businesses in England and elsewhere. At present, IELS is a fledgling product, but it may in time further add to the explanatory and governing power of the OECD to steer national policy makers towards a homogenised educational future defined by the organisation. IELS is run and managed by the National Foundation for Education Research (NFER), a national not-for-profit research organisation. The article explores how this same not-for-profit organisation also won the remarkably similar early childhood English Baseline Assessment 2 worth £9.8 million. Finally, the article examines the possibility that, in the future, if IELS were to develop, the edu-business Pearson might be interested in IELS to add to its existing interests in global data governance for profit