Overview of Neuroimaging Phenotypes

Talk given as part of the "Introduction to Imaging Genetics" workshop during the 2010 Organization for Human Brain Mapping (OHBM) conference in Barcelona

Overview of neuroimaging phenotypes

Talk given during the "Introduction to Imaging Genetics" workshop at the 2011 Organization for Human Brain Mapping (OHBM) conference in in Quebec City, June 10-14

overlap matrix.

<p>(A) Matrix of 30RSN×28BA (Brodmann Area). 20*: BA20+BA38, 41*: BA41+42, 28*: BA28+BA34+BA35+BA36, 32*:BA32+BA24+BA25, 23*:BA23+BA29+BA30+BA31, (B) Matrix of 30RSN×7BAF (Brodmann Area Family), see the details concerning the BAFs and RSNs in the text. Both matrices are reorganized by applying the same Expectation Maximization (EM) algorithm as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone-0067444-g002" target="_blank">Fig. 2C</a>, to reveal the RSNs clusters with a similar topography on the cortical surface. The RSNs are ranked on the vertical axis according to this clustering. BA×RSN matrix clusters: 1 (RSN# 1, 23, 2, 5, 22, 9), 2 (20, 21), 3 (4, 7, 18), 4 (14, 25, 27, 32,17), 5 (24, 13, 29, 28, 30, 11, 19, 31, 26, 16), 6 (3, 15) and 7 (6, 8). matrix clusters: 1 (RSN# 2, 22, 9, 5), 2 (4,7,21), 3 (18), 4 (20), 5 (25, 14, 17, 32), 6 (27, 28, 11, 29, 13, 19, 6, 26, 18, 20, 8 and 24), 7 (3, 15, 30, 16), 8 (31), 9 (23) and 10 (1). Color bars (to the right of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone-0067444-g003" target="_blank">Figures 3A, 3B</a>) indicate: visual (red), somatomotor (orange), auditory (green), left, right and bilateral RSNs (red) and as in Table in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone-0067444-g002" target="_blank">Fig. 2C</a>, RSNs of intermediate region are in (black). Scale bars represent the number of shared voxels.</p

The dual intertwined rings architecture.

<p>(A1) The VSA ring, in blue, forms a continuous cortical ring organized around primary cortices: visual (V), auditory (A) and somatomotor (S) with interspersed bimodal regions: visuo-somatomotor (VS), auditory-somatomotor (SA) and visuo-auditory (VA). (A2) The PTF ring, in red, forms a ring discontinuous over the cortical mantle but closed by major cortical fiber tracts (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone-0067444-g006" target="_blank">Fig. 6</a>), with 3 regions, parietal, temporal and frontal on the lateral (l) aspect of each hemisphere (lP,lT,lF) and 3 regions parietal, temporal and frontal, on the medial (m) aspect (mP,mT,mF). (B) The two rings are intertwined: the PTF ring, in red, is placed in foreground, to show that it is not continuous over the cortical mantle but interrupted by the VSA ring and is closed by major cortical fiber tracts passing below the VSA ring, as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone-0067444-g006" target="_blank">Fig. 6</a>.</p

Mapping of VSA and PTF families.

<p>(A) Comparison of clustering results on the 3 matrices , and . All clustering results are obtained with the same method: Mixture Distribution Algorithm. is a cluster of RSNs obtained from matrix (RSNxi), , , where p is the number of clusters. IR: Intermediate Regions are represented by RSN# 1, 23, 27 (B) Mapping of the 2 families which group the RSNs, according to the clustering based on functional specialization (as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone-0067444-g002" target="_blank">Fig. 2</a>) and the clustering based on cortical topography (shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone-0067444-g003" target="_blank">Fig. 3</a>), giving both the same results: VSA family formed by 3 clusters, LR (Left and Right = bilateral) Visual RSNs, in blue; LR Auditory RSNs in green and LR somatomotor RSNs in orange, with similar colors as in Table in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone-0067444-g002" target="_blank">Fig. 2C</a>. PTF family: R (right lateralized) RSNs in dark purple, L (left lateralized) RSNs in light purple and LR (bilateral) RSNs in red, distributed over the parietal, frontal, temporal and cingular regions. (C) The two intertwined rings per hemisphere: the visual, somatomotor and auditory RSNs clusters shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone-0067444-g004" target="_blank">Fig. 4</a> and grouped in the VSA family form the VSA ring, in blue, and the RSNs of the PTF family, distributed over the parietal, temporal, frontal and cingular regions form the PTF ring, in red. The overlap between the two families is shown in purple. The two rings are intertwined as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone-0067444-g007" target="_blank">Fig. 7</a>.</p

Mapping and representativeness of RSNs and similarities in two different populations.

<p>(A) Mapping of the 32 Resting State Networks (RSNs), on the right hemisphere (above) and the left hemisphere (below), on the lateral face (left) and the medial face (right). (B) Representativeness of the 32 RSNs. The color of each bar corresponds to the color of the RSNs network in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone-0067444-g001" target="_blank">Figure 1A</a> and the RSNs are labeled with their representativeness rank. (C) Spatial similarity rate between equivalent RSNs in the Cambridge and Beijing populations.</p

RSN×TBN overlap matrix.

<p>(A) RSN×TBN matrix showing overlaps (topographical similarity) between the 32 Resting State Networks (RSN, vertical axis) and the 18 reference Task Based Networks (TBNs, horizontal axis). The RSN are labeled as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone-0067444-g001" target="_blank">Fig. 1</a> and the TBNs are labeled as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone.0067444-Laird1" target="_blank">[14]</a>. The RSNs and TBNs are ranked according to the maximum of their overlaps. (B) RSN×TBN matrix reorganized by applying an Expectation Maximization (EM) algorithm to display the RSN clusters having similar overlaps with the TBNs (see text for details). The RSN×TBN clusters are: 1 (RSN# 2, 5, 22, 9), 2 (20, 7, 18, 21), 3 (4), 4 (14, 25), 5 (32, 17, 27) and 6 (6, 1, 23, 24, 13, 29, 3, 28, 30, 11, 19, 31, 26, 8, 16, 15). The color bars (at the right of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone-0067444-g002" target="_blank">Figure 2B</a>) indicate: visual (blue), somatomotor (orange), auditory (green), left, right and bilateral RSN (red), and RSNs of intermediate region (black). Scale bars represents the nuber of shared voxels. (C) This table shows the correspondence between RSNs and TBNs obtained by the maximal overlap between them, with the main sensory-motor and cognitive functions of the TBNs. The masks, labels and functions of TBNs are taken from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone.0067444-Laird1" target="_blank">[14]</a>. The labels of RSNs correspond to their representativeness in the group of subjects, as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone-0067444-g001" target="_blank">Fig. 1</a>. The colors used for RSNs labels, are the same as color bars in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067444#pone-0067444-g002" target="_blank">Fig. 2B</a>.</p

Long distance cortical connections closing the PTF ring.

<p>Comparison of the topography of the two rings (lateral and dorsal views), with superimposed major cortical fiber tracts (see text for details). Mapping of major long-distance fiber tracts on the 3D mask of the PTF ring (Fig. A) and VSA ring (Fig. B). Long-range connections on the VSA ring and the PTF ring, mapped together (Fig. C).</p

Intertwining scheme.

<p>Schematic representation of the principle of intertwining of the VSA ring and the PTF ring within each hemisphere, thanks to the major long-range tract fibers.</p

Population mean (Mean) and population variance (Standard deviation, SD) for Percent BOLD Signal Change (Ambiguous Facial expressions vs. Control Stimuli) and the Degree of Functional Connectivity (number of regions correlated with an r>0.3).

<p>Population mean (Mean) and population variance (Standard deviation, SD) for Percent BOLD Signal Change (Ambiguous Facial expressions vs. Control Stimuli) and the Degree of Functional Connectivity (number of regions correlated with an r>0.3).</p