Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala.

Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/NK-1R system, and its neuroadaptation following chronic alcohol exposure. In naïve rats, SP increased action potential-dependent GABA release, and the selective NK-1R antagonist L822429 decreased it, demonstrating SP regulation of CeM activity under basal conditions. SP induced a larger GABA release in alcohol-dependent rats accompanied by decreased NK-1R expression compared to naïve controls, suggesting NK-1R hypersensitivity which persisted during protracted alcohol withdrawal. The NK-1R antagonist blocked acute alcohol-induced GABA release in alcohol-dependent and withdrawn but not in naïve rats, indicating that dependence engages the SP/NK-1R system to mediate acute effects of alcohol. Collectively, we report long-lasting CeA NK-1R hypersensitivity corroborating that NK-1Rs are promising targets for the treatment of alcohol use disorder

A Simple UV-Completion of QED in 5D

We construct a Lifshitz-like version of five-dimensional (5D) QED which is UV - completed and reduces at low energies to ordinary 5D QED. The UV quantum behaviour of this theory is very smooth. In particular, the gauge coupling constant is finite at all energy scales and at all orders in perturbation theory. We study the IR properties of this theory, when compactified on a circle, and compare the one-loop energy dependence of the coupling in the Lifshitz theory with that coming from the standard 5D QED effective field theory. The range of validity of the 5D effective field theory is found to agree with the more conservative version of Naive Dimensional Analysis.Comment: 24 pages, 7 figures; v2: Minor improvements, matches journal versio

Nonequilibrium dressing in a cavity with a movable reflecting mirror

We consider a movable mirror coupled to a one-dimensional massless scalar field in a cavity. Both the field and the mirror's mechanical degrees of freedom are described quantum-mechanically, and they can interact each other via the radiation pressure operator. We investigate the dynamical evolution of mirror and field starting from a nonequilibrium initial state, and their local interaction which brings the system to a stationary configuration for long times. This allows us to study the time-dependent dressing process of the movable mirror interacting with the field, and its dynamics leading to a local equilibrium dressed configuration. Also, in order to explore the effect of the radiation pressure on both sides of the movable mirror, we generalize the effective field-mirror Hamiltonian and previous results to the case of two cavities sharing the same mobile boundary. This leads us to address, in the appropriate limit, the dynamical dressing problem of a single mobile wall, bounded by a harmonic potential, in the vacuum space.Comment: 10 pages, 4 figure