Kaplan-Meier child survival analysis according to baseline maternal CD4+ count (above or below 350/mm³).

<p>Kaplan-Meier child survival analysis according to baseline maternal CD4+ count (above or below 350/mm³).</p

Cohort profile.

<p>Cohort profile.</p

Novel Quinolinonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, and Biological Activities

Novel quinolinonyl diketo acids were designed to obtain integrase (IN) inhibitors selectively active against the strand transfer (ST) step of the HIV integration process. Those new compounds are characterized by a single aryl diketo acid (DKA) chain in comparison to <b>4</b>, a bifunctional diketo acid reported by our group as an anti-IN agent highly potent against both the 3′-processing and ST steps. Compound <b>6d</b> was the most potent derivative in IN enzyme assays, while <b>6i</b> showed the highest potency against HIV-1 in acutely infected cells. The selective inhibition of ST suggested the newly designed monofunctional DKAs bind the IN−DNA acceptor site without affecting the DNA donor site