Demographics and descriptive characteristics of cases and controls.

<p>Demographics and descriptive characteristics of cases and controls.</p

Smoking, alcohol, dietary folate and adenoma risk by genotype among all subjects.

a<p>Odds ratios (ORs) are from models with genotype coded as log-additive (treated as continuous) and adjusted for age, sex, clinic, exam date, study phase, and race among all study participants. Excludes 21 individuals who characterized their race/ethnic group as "other";</p>b<p>ORs for smoking additionally adjusted for alcohol intake (g/d) and dietary folate intake (mcg/day); ORs for alcohol additionally adjusted for smoking pack-years and dietary folate intake (mcg/d); ORs for dietary folate intake, additionally adjusted for alcohol intake (g/d) and smoking pack-years;</p>c<p>ORs derived from a common baseline model that included the SNP, smoking, alcohol, dietary folate exposure and interaction terms between genotype and smoking, alcohol, dietary folate exposure levels;</p>d<p>Crude interaction p-value;</p>e<p>Within gene region, Bonferroni adjusted interaction p-value, based on the number of SNPs within the respective gene region;</p>f<p>Pathway wide, Bonferroni adjusted interaction p-value, based on 14 investigated BER gene regions.</p

Significant BER per-allele associations by polyp sub-site.

a<p>Excludes 21 individuals who characterized their race/ethnic group as "other.";</p>b<p>Per-allele ORs and 95%confidence intervals computed using multinomial logistic regression assuming a log-additive model and adjusting for age, exam date, sex, clinic, study phase, and race among all study participants;</p>c<p>Crude p-value;</p>d<p>Crude p-value corrected for multiple comparisons using P_ACT;</p>e<p>Pathway wide (p_pathway) p-value based on Bonferroni correction of P_ACT for the number of BER gene regions investigated (N = 14);</p>f<p>p-value for heterogeneity by polyp subsite.</p

Colorectal adenoma SNP associations among the entire population and stratified by race/ethnicity.

a<p>Excludes 21 individuals who characterized their race/ethnic group as "other";</p>b<p>Per-allele ORs and 95%confidence intervals computed using logistic regression assuming a log-additive model and adjusting for age, exam date, sex, clinic, study phase and race among all study participants;</p>c<p>Crude p-value;</p>d<p>Crude p-value corrected for multiple comparisons using P_ACT;</p>e<p>Race/ethnicity specific per-allele ORs and 95% confidence intervals computed using logistic regression assuming a log-additive model and adjusting for the matching factors age, exam date, sex, clinic, study phase; ^e p-value for heterogeneity by race.</p

Expression of four genes found to differ by genotype for three colorectal cancer risk variants.

<p>Box plots of normalized gene expression levels of <i>ATP5C1</i>, <i>DLGAP5</i>, <i>NOL3</i>, <i>and DDX28</i> for paired adjacent normal colon tissue (n = 40) and colon tumor tissue (n = 40). Each point represents the normalized RNA expression levels for an individual. The median gene expression level for each genotype specific group is indicated by a line inside each box within the graph. The <i>p</i>-value indicates the significance of the global test comparing expression across genotypes. If the p-values were significant (<i>p</i>-value≤0.05), the FDR <i>q</i>-values were provided, indicating the significance after correction for multiple comparisons.</p

Nineteen established CRC risk variants identified by GWAS and their proxies considered in this study.

a<p>Position based on dbSNP build 130.</p>b<p>Major allele/minor allele among Europeans.</p>c<p>Minor allele frequencies from published reports.</p>d<p>Linkage disequilibrium between SNP and proxy in HapMap CEU.</p>e<p>Not on Affymetrix 6.0 array.</p>f<p>Excluded from analysis as proxy r²<0.90.</p

Tumor versus adjacent normal gene expression profiles of the <i>cis</i>-eQTL associated genes.

<p>Box plots of gene expression levels for <i>ATP5C1</i>, <i>DLGAP5</i>, <i>NOL3</i>, <i>and DDX28</i> in paired adjacent normal colon tissue and colon tumor tissue (n = 40 pairs). The significance of differential expression is indicated by the <i>p</i>-value.</p

Established colorectal cancer risk variants significantly associated with differential gene expression after multiple testing correction.

a<p>Based on the alleles of the proxy SNP.</p

Selected characteristics of cases and sibling controls from participants in the Colon Cancer Family Registry.

1<p>Non-Hispanic white family-based discordant siblings with age and sex data. ²Self-reported weight and height 2 years prior to questionnaire completion date used to calculate body mass index (BMI). ³Average weekly total lifetime MET hours. ⁴Estimated from 1-df likelihood ratio test from a conditional logistic regression model.</p

<i>SMAD7</i> tagging SNPs and colorectal cancer risk in the Colon Cancer Family Registry.

1<p>Minor allele frequencies (MAFs) were estimated using unrelated population-based controls. ²Results were estimated using a log-additive model, adjusted for age and sex.</p