Can these salt substitutes prevent complications of hypertension?

Can these salt substitutes prevent complications of hypertension? This study suggests the blood pressure–lowering effects of potassium-enriched salt substitutes may reduce cardiovascular morbidity and mortality.Edward T. Chang, MD; Robert Powell, DO; Tyler Reese, MD (Leader and Faculty Development Fellowship Program, Madigan Army Medical Center, Joint Base)Includes bibliographical reference

Continuity and Internal Properties of Gulf Coast Sandstones and their Implications for Geopressured Energy Development

The continuity of sandstone reservoirs is controlled by various factors including structural trend, sand-body geometry, and the distribution of framework grains, matrix, and interstices within the sand body. Except for the limits imposed by faults, these factors are largely inherited from the depositional environment and modified during sandstone compaction and cementation. Regional and local continuity of sandstone reservoirs depends on a depositional and structural hierarchy of four levels: (1) genetically related sandstones commonly associated with a single depositional system, (2) areally extensive fault blocks, (3) individual sandstones within a fault block, and (4) isolated reservoirs within a fault-bounded sandstone. Compilation of published and unpublished data for Tertiary and late Quaternary Gulf Coast sandstones of fluvial, deltaic, barrier-strandplain, and submarine fan origins suggests that volumes of sand systems (first hierarchical level) range from 10^11 to 10^13 ft^3, whereas volumes of individual sand bodies range from 10^9 to 10^11 ft^3. The continuity and productive limits of the ancient sandstones are substantially reduced by faults and internal heterogeneity that further subdivide the sand body into individual compartments. For the Wilcox and Frio trends of Texas, fault blocks (second hierarchical level) vary greatly in size, most being between 0.3 and 52 mi^2 in area; however, the distribution is strongly skewed toward small areas. Volumes of individual reservoirs (fourth hierarchical level) determined from engineering production data are 50 percent less to 200 percent more than estimates obtained from geologic mapping. In general, mapped volumes underestimate actual volumes where faults are non-sealing and overestimate actual volumes where laterally continuous shale breaks cause reductions in porosity and permeability.Bureau of Economic Geolog

Intraoperative Neurophysiological Monitoring for Endoscopic Endonasal Approaches to the Skull Base: A Technical Guide.

Intraoperative neurophysiological monitoring during endoscopic, endonasal approaches to the skull base is both feasible and safe. Numerous reports have recently emerged from the literature evaluating the efficacy of different neuromonitoring tests during endonasal procedures, making them relatively well-studied. The authors report on a comprehensive, multimodality approach to monitoring the functional integrity of at risk nervous system structures, including the cerebral cortex, brainstem, cranial nerves, corticospinal tract, corticobulbar tract, and the thalamocortical somatosensory system during endonasal surgery of the skull base. The modalities employed include electroencephalography, somatosensory evoked potentials, free-running and electrically triggered electromyography, transcranial electric motor evoked potentials, and auditory evoked potentials. Methodological considerations as well as benefits and limitations are discussed. The authors argue that, while individual modalities have their limitations, multimodality neuromonitoring provides a real-time, comprehensive assessment of nervous system function and allows for safer, more aggressive management of skull base tumors via the endonasal route

Biorefinery process for protein extraction from oriental mustard (Brassica juncea (L.) Czern.) using ethanol stillage

Large volumes of treated process water are required for protein extraction. Evaporation of this water contributes greatly to the energy consumed in enriching protein products. Thin stillage remaining from ethanol production is available in large volumes and may be suitable for extracting protein rich materials. In this work protein was extracted from ground defatted oriental mustard (Brassica juncea (L.) Czern.) meal using thin stillage. Protein extraction efficiency was studied at pHs between 7.6 and 10.4 and salt concentrations between 3.4 × 10-2 and 1.2 M. The optimum extraction efficiency was pH 10.0 and 1.0 M NaCl. Napin and cruciferin were the most prevalent proteins in the isolate. The isolate exhibited high in vitro digestibility (74.9 ± 0.80%) and lysine content (5.2 ± 0.2 g/100 g of protein). No differences in the efficiency of extraction, SDS-PAGE profile, digestibility, lysine availability, or amino acid composition were observed between protein extracted with thin stillage and that extracted with NaCl solution. The use of thin stillage, in lieu of water, for protein extraction would decrease the energy requirements and waste disposal costs of the protein isolation and biofuel production processes

Examining Care Navigation: Librarian Participation in a Teambased Approach?

Objective: This study investigated responsibilities, skill sets, degrees, and certifications required of health care navigators in order to identify areas of potential overlap with health sciences librarianship. Method: The authors conducted a content analysis of health care navigator position announcements and developed and assigned forty-eight category terms to represent the sample’s responsibilities and skill sets. Results: Coordination of patient care and a bachelor’s degree were the most common responsibility and degree requirements, respectively. Results also suggest that managing and providing health information resources is an area of overlap between health care navigators and health sciences librarians, and that librarians are well suited to serve on navigation teams. Conclusion: Such overlap may provide an avenue for collaboration between navigators and health sciences librarians

Examining MEDLINE Search Query Reproducibility and Resulting Variation in Search Results

The MEDLINE database is publicly available through the National Library of Medicine’s PubMed but the data file itself is also licensed to a number of vendors, who may offer their versions to institutional and other parties as part of a database platform. These vendors provide their own interface to the MEDLINE file and offer other technologies that attempt to make their version useful to subscribers. However, little is known about how vendor platforms ingest and interact with MEDLINE data files, nor how these changes influence the construction of search queries and the results they produce. This poster presents a longitudinal study of five MEDLINE databases involving 29 sets of logically and semantically consistent search queries (five search queries for each set). The goal is to understand whether it is possible to reproduce search queries by: a) analyzing search query syntax per database, and b) controlling for total search results. We also highlight the barriers to creating reproducible queries across MEDLINE databases

Search Results Outliers Among MEDLINE Platforms

Objective: Hypothetically, content in MEDLINE records is consistent across multiple platforms. Though platforms have different interfaces and requirements for query syntax, results should be similar when the syntax is controlled for across the platforms. The authors investigated how search result counts varied when searching records among five MEDLINE platforms. Methods: We created 29 sets of search queries targeting various metadata fields and operators. Within search sets, we adapted 5 distinct, compatible queries to search 5 MEDLINE platforms (PubMed, ProQuest, EBSCOhost, Web of Science, and Ovid), totaling 145 final queries. The 5 queries were designed to be logically and semantically equivalent and were modified only to match platform syntax requirements. We analyzed the result counts and compared PubMed’s MEDLINE result counts to result counts from the other platforms. We identified outliers by measuring the result count deviations using modified z-scores centered around PubMed’s MEDLINE results. Results: Web of Science and ProQuest searches were the most likely to deviate from the equivalent PubMed searches. EBSCOhost and Ovid were less likely to deviate from PubMed searches. Ovid’s results were the most consistent with PubMed’s but appeared to apply an indexing algorithm that resulted in lower retrieval sets among equivalent searches in PubMed. Web of Science exhibited problems with exploding or not exploding Medical Subject Headings (MeSH) terms. Conclusion: Platform enhancements among interfaces affect record retrieval and challenge the expectation that MEDLINE platforms should, by default, be treated as MEDLINE. Substantial inconsistencies in search result counts, as demonstrated here, should raise concerns about the impact of platform-specific influences on search results

Consolidation of Geologic Studies of Geopressured-Geothermal Resources in Texas

Two major structural styles are identified in the Wilcox growth-fault trend of the Texas Gulf Coast. The style in central and southeast Texas is characterized by continuous, closely spaced growth faults that have little associated rollover despite moderate expansion of section and that show little flattening of the fault plane with depth. Where the growth-fault trend crosses the Houston Diapir Province, growth faults are localized by preexisting salt pillows; however, the piercement salt domes formed after the main phase of faulting, so the salt tectonics "overprints" the growth faults. In South Texas (south of Live Oak County), a narrow band of growth faults having high expansion and moderate rollover lies over and downdip of a ridge of deformed, overpressured shale and lies updip of a deep Tertiary-filled basin formed by withdrawal of overpressured shale. Significant antithetic faulting is associated with this band of growth faults. Also in South Texas, the lower Wilcox Lobo trend is deformed by highly listric normal faults beneath an unconformity that is probably related to Laramide tectonic activity. Wilcox sandstone reservoirs are predominantly of high-constructive deltaic (distributary-channel and delta-front) origin. This, together with close spacing of faults and characteristically low permeabilities, limits the size of geopressured reservoirs. The largest reservoirs may be in interfault areas or in salt- or shale-withdrawal basins.Bureau of Economic Geolog

MEDLINE Search Retrieval Issues: A Longitudinal Query Analysis of Five Vendor Platforms

This study compared the results of data collected from a longitudinal query analysis of the MEDLINE database hosted on multiple platforms that include PubMed, EBSCOHost, Ovid, ProQuest, and Web of Science. The goal was to identify variations among the search results on the platforms after controlling for search query syntax. We devised twenty-nine cases of search queries comprised of five semantically equivalent queries per case to search against the five MEDLINE database platforms. We ran our queries monthly for a year and collected search result count data to observe changes. We found that search results varied considerably depending on MEDLINE platform. Reasons for variations were due to trends in scholarly publication such as publishing individual papers online first versus complete issues. Some other reasons were metadata differences in bibliographic records; differences in the levels of specificity of search fields provided by the platforms and large fluctuations in monthly search results based on the same query. Database integrity and currency issues were observed as each platform updated its MEDLINE data throughout the year. Specific biomedical bibliographic databases are used to inform clinical decision-making, create systematic reviews, and construct knowledge bases for clinical decision support systems. They serve as essential information retrieval and discovery tools to help identify and collect research data and are used in a broad range of fields and as the basis of multiple research designs. This study should help clinicians, researchers, librarians, informationists, and others understand how these platforms differ and inform future work in their standardization