Mineralogy and provenance of the TiO₂ - ilmenite heavy mineral sand deposit of Nataka

The Nataka heavy mineral sand deposit occurs along the northeast Mozambique coastline. It comprises a regional Pleistocene elliptical structure extending from Somalia, passing through Kenya, Tanzania, Madagascar and Mozambique, to Richards Bay in South Africa. The deposit consists of fine- to medium- grained, unconsolidated red sediments, hosting heavy minerals. The deposit mineral assemblage is made up of non-valuable phases comprising mostly magnetite, hematite, chromite, monazite, and the valuable phases dominated by ilmenite (50.91 wt. %), with additional zircon and rutile (9.96 and 3.52 wt. % respectively). The total heavy minerals comprise about 5% volume, of which 2 % are valuable heavy minerals making up about 445 Mt (million tonnes) probable resources. This study focuses on the mineralogical characterization of ilmenite from the Nataka deposit, alongside with sediment provenance. Mineralogical and chemical characterisation of ilmenite undertaken on 32 samples from 16 selected drill holes using a combination of QEMSCAN and EPMA revealed that the ilmenite has undergone different stages of alteration, at distinct environment conditions, yielding products spanning from hydrated ilmenite to leucoxene. The alteration dominantly involved groundwater, which was oxidizing and acidic, hence the predominance of ilmenite-pseudorutile alteration. Long exposure to direct sunshine has been hypothesized as a different process that might have favoured the direct alteration of ilmenite to leucoxene and of pseudorutile to leucoxene, on a smaller scale. The major impurities in the ilmenite are Al and Si, which are enriched in the advanced ilmenite alteration products (leucoxene), where they fill pores and cracks. Chromium impurities occur as discrete grains of chrome spinel. The compositional variety of magnetite, Cr-spinel, tourmaline, zircon and rutile indicate major contribution from granitoid terranes, subjected to granulite metamorphic facies (750 to 1000 :C), and minor contribution from mafic plutonic intrusions. The granitoid field as a sediment source area if analysed in conjunction with zircon ages (1100 – 900 Ma, 900 – 700 Ma, and 650 – 500 Ma), and zircon δ¹⁸O (7.07 ‰) is consistent with preferential sourcing from the proximal Mesoproterozoic Nampula Complex, with some contribution from igneous plutonic rocks from Xixano, Lalamo and Montepuez Complexes

UV Imaging Polarimetry of the Seyfert 2 Galaxy Mrk 3

We present UV imaging polarimetry data of the Seyfert 2 galaxy Mrk 3 taken by the Hubble Space Telescope. The polarized flux is found to be extended to ~1 kpc from the nucleus, and the position angles of polarization are centrosymmetric, confirming that the polarization is caused by scattering. We determine the location of the hidden nucleus as the center of this centrosymmetric pattern. From the polarization images taken in two broad bands, we have obtained the color distribution of the polarized flux. Some regions have blue polarized flux, consistent with optically-thin dust scattering, but some bright knots have a color similar to that of Seyfert 1 nucleus. Also, the recent Chandra X-ray observation suggests that the ratio of scattered UV flux to scattered X-ray flux is rather similar to the intrinsic UV/X-ray ratio in a Seyfert 1 nucleus, if the observed extended X-ray continuum is scattered light. While the scattered X-ray would be essentially from electron scattering, the UV slope and UV/X-ray ratio both being similar to Seyfert 1's would lead to two possibilities as to the nature of the UV scatterers. One is that the UV may also be scattered by electrons, in which case the scattering gas is somehow dust-free. The other is that the UV is scattered by dust grains, but the wavelength-independent UV scattering with low efficiency indicated by the UV slope and UV/X-ray ratio would suggest that the grains reside in UV-opaque clouds, or the dust might be mainly composed of large grains and lacks small-grain population.Comment: 15 pages, 8 figures (plus 2 color versions of grayscale figures), To appear in ApJ; minor corrections for the proofs of the manuscrip

Nuclear Bar Catalyzed Star Formation: 13^CO, C18^O and Molecular Gas Properties in the Nucleus of Maffei 2

(Abridged) We present resolution maps of CO, its isotopologues, and HCN from in the center of Maffei 2. The J=1-0 rotational lines of 12^CO, 13^CO, C18^O and HCN, and the J=2-1 lines of 13^CO and C18^O were observed with the OVRO and BIMA arrays. The 2-1/1-0 line ratios of the isotopologues constrain the bulk of the molecular gas to originate in low excitation, subthermal gas. From LVG modeling, we infer that the central GMCs have n(H_2) ~10^2.75 cm^-3 and T_k ~ 30 K. Continuum emission at 3.4 mm, 2.7 mm and 1.4 mm was mapped to determine the distribution and amount of HII regions and dust. Column densities derived from C18^O and 1.4 mm dust continuum fluxes indicate the CO conversion factor in the center of Maffei 2 is lower than Galactic by factors of ~2-4. Gas morphology and the clear ``parallelogram'' in the Position-Velocity diagram shows that molecular gas orbits within the potential of a nuclear (~220 pc) bar. The nuclear bar is distinct from the bar that governs the large scale morphology of Maffei 2. Giant molecular clouds in the nucleus are nonspherical and have large linewidths. Dense gas and star formation are concentrated at the sites of the x_1-x_2 orbit intersections of the nuclear bar, suggesting that the starburst is dynamically triggered.Comment: 50 pages, 14 figures, accepted for publication in Ap

The Hawaii Infrared Parallax Program. VI. The Fundamental Properties of 1000+ Ultracool Dwarfs and Planetary-mass Objects Using Optical to Mid-IR SEDs and Comparison to BT-Settl and ATMO 2020 Model Atmospheres

We derive the bolometric luminosities ($L_{\mathrm{bol}}$) of 865 field-age and 189 young ultracool dwarfs (spectral types M6-T9, including 40 new discoveries presented here) by directly integrating flux-calibrated optical to mid-IR spectral energy distributions (SEDs). The SEDs consist of low-resolution ($R\sim$ 150) near-IR (0.8-2.5 $\mu$m) spectra (including new spectra for 97 objects), optical photometry from the Pan-STARRS1 survey, and mid-IR photometry from the CatWISE2020 survey and Spitzer/IRAC. Our $L_{\mathrm{bol}}$ calculations benefit from recent advances in parallaxes from Gaia, Spitzer, and UKIRT, as well as new parallaxes for 19 objects from CFHT and Pan-STARRS1 presented here. Coupling our $L_{\mathrm{bol}}$ measurements with a new uniform age analysis for all objects, we estimate substellar masses, radii, surface gravities, and effective temperatures ($T_{\mathrm{eff}}$) using evolutionary models. We construct empirical relationships for $L_{\mathrm{bol}}$ and $T_{\mathrm{eff}}$ as functions of spectral type and absolute magnitude, determine bolometric corrections in optical and infrared bandpasses, and study the correlation between evolutionary model-derived surface gravities and near-IR gravity classes. Our sample enables a detailed characterization of BT-Settl and ATMO 2020 atmospheric model systematics as a function of spectral type and position in the near-IR color-magnitude diagram. We find the greatest discrepancies between atmospheric and evolutionary model-derived $T_{\mathrm{eff}}$ (up to 800 K) and radii (up to 2.0 $R_{\mathrm{Jup}}$) at the M/L transition boundary. With 1054 objects, this work constitutes the largest sample to date of ultracool dwarfs with determinations of their fundamental parameters.Comment: Resubmitted to The Astrophysical Journal (ApJ) after a positive referee report. 51 pages, 29 figures, 7 tables. Data presented in this work: https://doi.org/10.5281/zenodo.8315643. Scripts associated with methods: https://github.com/cosmicoder/HIPPVI-Cod

Evaluation of recombinant influenza virus-simian immunodeficiency virus vaccines in macaques

There is an urgent need for human immunodeficiency virus (HIV) vaccines that induce robust mucosal immunity. Influenza A viruses (both H1N1 and H3N2) were engineered to express simian immunodeficiency virus (SIV) CD8 T-cell epitopes and evaluated following administration to the respiratory tracts of 11 pigtail macaques. Influenza virus was readily detected from respiratory tract secretions, although the infections were asymptomatic. Animals seroconverted to influenza virus and generated CD8 and CD4 T-cell responses to influenza virus proteins. SIV-specific CD8 T-cell responses bearing the mucosal homing marker 7 integrin were induced by vaccination of naïve animals. Further, SIV-specific CD8 T-cell responses could be boosted by recombinant influenza virus-SIV vaccination of animals with already-established SIV infection. Sequential vaccination with influenza virus-SIV recombinants of different subtypes (H1N1 followed by H3N2 or vice versa) produced only a limited boost in immunity, probably reflecting T-cell immunity to conserved internal proteins of influenza A virus. SIV challenge of macaques vaccinated with an influenza virus expressing a single SIV CD8 T cell resulted in a large anamnestic recall CD8 T-cell response, but immune escape rapidly ensued and there was no impact on chronic SIV viremia. Although our results suggest that influenza virus-HIV vaccines hold promise for the induction of mucosal immunity to HIV, broader antigen cover will be needed to limit cytotoxic T-lymphocyte escape

Near and Mid-IR Photometry of the Pleiades, and a New List of Substellar Candidate Members

We make use of new near and mid-IR photometry of the Pleiades cluster in order to help identify proposed cluster members. We also use the new photometry with previously published photometry to define the single-star main sequence locus at the age of the Pleiades in a variety of color-magnitude planes. The new near and mid-IR photometry extend effectively two magnitudes deeper than the 2MASS All-Sky Point Source catalog, and hence allow us to select a new set of candidate very low mass and sub-stellar mass members of the Pleiades in the central square degree of the cluster. We identify 42 new candidate members fainter than Ks =14 (corresponding to 0.1 Mo). These candidate members should eventually allow a better estimate of the cluster mass function to be made down to of order 0.04 solar masses. We also use new IRAC data, in particular the images obtained at 8 um, in order to comment briefly on interstellar dust in and near the Pleiades. We confirm, as expected, that -- with one exception -- a sample of low mass stars recently identified as having 24 um excesses due to debris disks do not have significant excesses at IRAC wavelengths. However, evidence is also presented that several of the Pleiades high mass stars are found to be impacting with local condensations of the molecular cloud that is passing through the Pleiades at the current epoch.Comment: Accepted to ApJS; data tables and embedded-figure version available at http://spider.ipac.caltech.edu/staff/stauffer/pleiades07

Effective, Robust Design of Community Mitigation for Pandemic Influenza: A Systematic Examination of Proposed US Guidance

BACKGROUND: The US government proposes pandemic influenza mitigation guidance that includes isolation and antiviral treatment of ill persons, voluntary household member quarantine and antiviral prophylaxis, social distancing of individuals, school closure, reduction of contacts at work, and prioritized vaccination. Is this the best strategy combination? Is choice of this strategy robust to pandemic uncertainties? What are critical enablers of community resilience? METHODS AND FINDINGS: We systematically simulate a broad range of pandemic scenarios and mitigation strategies using a networked, agent-based model of a community of explicit, multiply-overlapping social contact networks. We evaluate illness and societal burden for alterations in social networks, illness parameters, or intervention implementation. For a 1918-like pandemic, the best strategy minimizes illness to <1% of the population and combines network-based (e.g. school closure, social distancing of all with adults' contacts at work reduced), and case-based measures (e.g. antiviral treatment of the ill and prophylaxis of household members). We find choice of this best strategy robust to removal of enhanced transmission by the young, additional complexity in contact networks, and altered influenza natural history including extended viral shedding. Administration of age-group or randomly targeted 50% effective pre-pandemic vaccine with 7% population coverage (current US H5N1 vaccine stockpile) had minimal effect on outcomes. In order, mitigation success depends on rapid strategy implementation, high compliance, regional mitigation, and rigorous rescinding criteria; these are the critical enablers for community resilience. CONCLUSIONS: Systematic evaluation of feasible, recommended pandemic influenza interventions generally confirms the US community mitigation guidance yields best strategy choices for pandemic planning that are robust to a wide range of uncertainty. The best strategy combines network- and case-based interventions; network-based interventions are paramount. Because strategies must be applied rapidly, regionally, and stringently for greatest benefit, preparation and public education is required for long-lasting, high community compliance during a pandemic

Protostars in the Elephant Trunk Nebula

The optically-dark globule IC 1396A is revealed using Spitzer images at 3.6, 4.5, 5.8, 8, and 24 microns to be infrared-bright and to contain a set of previously unknown protostars. The mid-infrared colors of the 24 microns detected sources indicate several very young (Class I or 0) protostars and a dozen Class II stars. Three of the new sources (IC 1396A: gamma, delta, and epsilon) emit over 90% of their bolometric luminosities at wavelengths greater than 3 microns, and they are located within ~0.02 pc of the ionization front at the edge of the globule. Many of the sources have spectra that are still rising at 24 microns. The two previously-known young stars LkHa 349 a and c are both detected, with component c harboring a massive disk and component a being bare. Of order 5% of the mass of material in the globule is presently in the form of protostars in the 10^5 to 10^6 yr age range. This high star formation rate was likely triggered by radiation from a nearby O star.Comment: Spitzer first ApJS special issue (in press

Effect of Neuraminidase Inhibitor–Resistant Mutations on Pathogenicity of Clade 2.2 A/Turkey/15/06 (H5N1) Influenza Virus in Ferrets

The acquisition of neuraminidase (NA) inhibitor resistance by H5N1 influenza viruses has serious clinical implications, as this class of drugs can be an essential component of pandemic control measures. The continuous evolution of the highly pathogenic H5N1 influenza viruses results in the emergence of natural NA gene variations whose impact on viral fitness and NA inhibitor susceptibility are poorly defined. We generated seven genetically stable recombinant clade 2.2 A/Turkey/15/06-like (H5N1) influenza viruses carrying NA mutations located either in the framework residues (E119A, H274Y, N294S) or in close proximity to the NA enzyme active site (V116A, I117V, K150N, Y252H). NA enzyme inhibition assays showed that NA mutations at positions 116, 117, 274, and 294 reduced susceptibility to oseltamivir carboxylate (IC50s increased 5- to 940-fold). Importantly, the E119A NA mutation (previously reported to confer resistance in the N2 NA subtype) was stable in the clade 2.2 H5N1 virus background and induced cross-resistance to oseltamivir carboxylate and zanamivir. We demonstrated that Y252H NA mutation contributed for decreased susceptibility of clade 2.2 H5N1 viruses to oseltamivir carboxylate as compared to clade 1 viruses. The enzyme kinetic parameters (Vmax, Km and Ki) of the avian-like N1 NA glycoproteins were highly consistent with their IC50 values. None of the recombinant H5N1 viruses had attenuated virulence in ferrets inoculated with 106 EID50 dose. Most infected ferrets showed mild clinical disease signs that differed in duration. However, H5N1 viruses carrying the E119A or the N294S NA mutation were lethal to 1 of 3 inoculated animals and were associated with significantly higher virus titers (P<0.01) and inflammation in the lungs compared to the wild-type virus. Our results suggest that highly pathogenic H5N1 variants carrying mutations within the NA active site that decrease susceptibility to NA inhibitors may possess increased virulence in mammalian hosts compared to drug-sensitive viruses. There is a need for novel anti-influenza drugs that target different virus/host factors and can limit the emergence of resistance