A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity-8

<p><b>Copyright information:</b></p><p>Taken from "A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity"</p><p>http://www.biomedcentral.com/1741-7015/5/32</p><p>BMC Medicine 2007;5():32-32.</p><p>Published online 14 Nov 2007</p><p>PMCID:PMC2200657.</p><p></p> of each trial. Note a trend over time towards no effect. No summary statistic is shown owing to excessive heterogeneity

A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity-4

<p><b>Copyright information:</b></p><p>Taken from "A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity"</p><p>http://www.biomedcentral.com/1741-7015/5/32</p><p>BMC Medicine 2007;5():32-32.</p><p>Published online 14 Nov 2007</p><p>PMCID:PMC2200657.</p><p></p>atment arm (-axis) of each study. Studies are weighted by inverse variance (i.e. larger symbols represent larger studies with less variability). Open circles denote cluster 2 studies [10, 11, 14, 25]. : Box plot of change in creatinine from baseline to study endpoint in the control arm and NAC treatment arm of each study. Boxes represent the 25th, 50th and 75th percentiles. Whiskers are 5th and 95th percentiles. Dashed lines show the mean of each group. Open squares denote cluster 2 studies

A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity-6

<p><b>Copyright information:</b></p><p>Taken from "A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity"</p><p>http://www.biomedcentral.com/1741-7015/5/32</p><p>BMC Medicine 2007;5():32-32.</p><p>Published online 14 Nov 2007</p><p>PMCID:PMC2200657.</p><p></p>ine studies. Axes are in logarithmic scale. The RR of CIN would have to be less than 0.67 in order for the RR of hemodialysis not to be on the side of harm (RR < 1)

A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity-1

<p><b>Copyright information:</b></p><p>Taken from "A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity"</p><p>http://www.biomedcentral.com/1741-7015/5/32</p><p>BMC Medicine 2007;5():32-32.</p><p>Published online 14 Nov 2007</p><p>PMCID:PMC2200657.</p><p></p> of each trial. Note a trend over time towards no effect. No summary statistic is shown owing to excessive heterogeneity

A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity-2

<p><b>Copyright information:</b></p><p>Taken from "A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity"</p><p>http://www.biomedcentral.com/1741-7015/5/32</p><p>BMC Medicine 2007;5():32-32.</p><p>Published online 14 Nov 2007</p><p>PMCID:PMC2200657.</p><p></p> identified as contributing most to heterogeneity are noted with open circles and are seen to produce asymmetry in the plot. The summary log RR for all 22 studies is denoted by the open diamond

A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity-3

<p><b>Copyright information:</b></p><p>Taken from "A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity"</p><p>http://www.biomedcentral.com/1741-7015/5/32</p><p>BMC Medicine 2007;5():32-32.</p><p>Published online 14 Nov 2007</p><p>PMCID:PMC2200657.</p><p></p>dies. Removing any of the 10 studies at the top of the plot decreases heterogeneity, while removing any of the 12 studies at the bottom of the plot increases heterogeneity. The four studies that individually contributed the most to heterogeneity are shown as open circles. Circle size is proportional to the inverse variance

Expression of CD146 by various lymphocyte subsets in the peripheral blood of healthy volunteers

<p><b>Copyright information:</b></p><p>Taken from "A unique population of effector memory lymphocytes identified by CD146 having a distinct immunophenotypic and genomic profile"</p><p>http://www.biomedcentral.com/1471-2172/8/29</p><p>BMC Immunology 2007;8():29-29.</p><p>Published online 13 Nov 2007</p><p>PMCID:PMC2248207.</p><p></p> Bars indicate means for each subset. All cells were gated as described for Figure 1, with the addition of CD3 positive gating for CD4 and CD8, and CD3 negative gating for CD56

The microarray studies and analysis by Ingenuity™ (21) showed that CD+146 cells up-regulate a cluster of genes (red) that prepare them for the mechanisms of extravasation and destination to an inflammatory site

<p><b>Copyright information:</b></p><p>Taken from "A unique population of effector memory lymphocytes identified by CD146 having a distinct immunophenotypic and genomic profile"</p><p>http://www.biomedcentral.com/1471-2172/8/29</p><p>BMC Immunology 2007;8():29-29.</p><p>Published online 13 Nov 2007</p><p>PMCID:PMC2248207.</p><p></p> The green down-regulated gene (CCR7) indicates capability for the reverse migration, i.e. from peripheral tissues into vasculature or into lymphatic

Mononuclear cells from the peripheral blood of a normal volunteer were incubated with carboxyfluorescein diacetatesuccinimidylester (CFSE) and PHA, as described in the text

<p><b>Copyright information:</b></p><p>Taken from "A unique population of effector memory lymphocytes identified by CD146 having a distinct immunophenotypic and genomic profile"</p><p>http://www.biomedcentral.com/1471-2172/8/29</p><p>BMC Immunology 2007;8():29-29.</p><p>Published online 13 Nov 2007</p><p>PMCID:PMC2248207.</p><p></p> CFSE fluorescence reduced with each cellular division. The cells were cultured a total of five days. The upper left panel displays CFSE staining versus a PE isotype control of CD3+ cells. The upper right panel shows staining of PECD146 versus CFSE of CD3+ T cells. Lower panels display CFSE vs CD4 and CD8. CFSE staining decreased with each successive division of the T cells, and CD146 expression increased

A unique population of effector memory lymphocytes identified by CD146 having a distinct immunophenotypic and genomic profile-2

<p><b>Copyright information:</b></p><p>Taken from "A unique population of effector memory lymphocytes identified by CD146 having a distinct immunophenotypic and genomic profile"</p><p>http://www.biomedcentral.com/1471-2172/8/29</p><p>BMC Immunology 2007;8():29-29.</p><p>Published online 13 Nov 2007</p><p>PMCID:PMC2248207.</p><p></p>tivation. Only a small number of cells stained with both markers, indicating that largely unique subsets were identified by each. In healthy individuals, the percentage of HLA-Dr + T cells expressing CD146 was 5.5% (± 1.99%; n = 5), the percentage of CD25+ T cell expressing CD146 was 8.36% (± 1.86%; n = 5), the percentage of CD69+ T cells expressing CD146 was 8.47% (± 3.08%; n = 5), and the percentage of CD38+ T cells expressing CD146 was 0.53% (± 0.19%; n = 4)