Pennsylvania Folklife Vol. 27, No. 1

• Sulfur Inlay in Pennsylvania German Furniture • Orders What\u27s to be Done at the Plantation : The Isaac Norris Farm Accounts, 1713-1734 • Blacks in Berks County, Pennsylvania: The Almshouse Records • Teach, Preach, or Weave Stockings? The Trilemma of a Pennsylvania Scholar • Annotated Bibliography of Pennsylvania Folk Medicine • Pictures in the Home: Folk-Cultural Questionnaire No. 49https://digitalcommons.ursinus.edu/pafolklifemag/1075/thumbnail.jp

Impaired V(D)J Recombination and Lymphocyte Development in Core RAG1-expressing Mice

RAG1 and RAG2 are the lymphocyte-specific components of the V(D)J recombinase. In vitro analyses of RAG function have relied on soluble, highly truncated “core” RAG proteins. To identify potential functions for noncore regions and assess functionality of core RAG1 in vivo, we generated core RAG1 knockin (RAG1c/c) mice. Significant B and T cell numbers are generated in RAG1c/c mice, showing that core RAG1, despite missing ∼40% of the RAG1 sequence, retains significant in vivo function. However, lymphocyte development and the overall level of V(D)J recombination are impaired at the progenitor stage in RAG1c/c mice. Correspondingly, there are reduced numbers of peripheral RAG1c/c B and T lymphocytes. Whereas normal B lymphocytes undergo rearrangement of both JH loci, substantial levels of germline JH loci persist in mature B cells of RAG1c/c mice, demonstrating that DJH rearrangement on both IgH alleles is not required for developmental progression to the stage of VH to DJH recombination. Whereas VH to DJH rearrangements occur, albeit at reduced levels, on the nonselected alleles of RAG1c/c B cells that have undergone D to JH rearrangements, we do not detect VH to DH rearrangements in RAG1c/c B cells that retain germline JH alleles. We discuss the potential implications of these findings for noncore RAG1 functions and for the ordered assembly of VH, DH, and JH segments

Demonstration of a Scalable, Multiplexed Ion Trap for Quantum Information Processing

Author's final manuscript: July 9, 2009A scalable, multiplexed ion trap for quantum information processing is fabricated and tested. The trap design and fabrication process are optimized for scalability to small trap size and large numbers of interconnected traps, and for integration of control electronics and optics. Multiple traps with similar designs are tested with [superscript 111]Cd[superscript +], [superscript 25]Mg[superscript +], and [superscript 88]Sr[superscript +] ions at room temperature and with [superscript 88]Sr[superscript +] at 6 K, with respective ion lifetimes of 90 s, 300 ± 30 s, 56 ± 6 s, and 4.5 ± 1.1 hours. The motional heating rate for [superscript 25]Mg[superscript +] at room temperature and a trap frequency of 1.6 MHz is measured to be 7 ± 3 quanta per millisecond. For [superscript 88]Sr[superscript +] at 6 K and 540 kHz the heating rate is measured to be 220 ± 30 quanta per second.United States. Intelligence Advanced Research Projects ActivityNational Institute of Standards and Technology (U.S.) (Quantum Information Program

Classical wave-optics analogy of quantum information processing

An analogous model system for quantum information processing is discussed, based on classical wave optics. The model system is applied to three examples that involve three qubits: ({\em i}) three-particle Greenberger-Horne-Zeilinger entanglement, ({\em ii}) quantum teleportation, and ({\em iii}) a simple quantum error correction network. It is found that the model system can successfully simulate most features of entanglement, but fails to simulate quantum nonlocality. Investigations of how far the classical simulation can be pushed show that {\em quantum nonlocality} is the essential ingredient of a quantum computer, even more so than entanglement. The well known problem of exponential resources required for a classical simulation of a quantum computer, is also linked to the nonlocal nature of entanglement, rather than to the nonfactorizability of the state vector.Comment: 9 pages, 6 figure

MAKO: a pathfinder instrument for on-sky demonstration of low-cost 350 micron imaging arrays

Submillimeter cameras now have up to 10^4 pixels (SCUBA 2). The proposed CCAT 25-meter submillimeter telescope will feature a 1 degree field-of-view. Populating the focal plane at 350 microns would require more than 10^6 photon-noise limited pixels. To ultimately achieve this scaling, simple detectors and high-density multiplexing are essential. We are addressing this long-term challenge through the development of frequency-multiplexed superconducting microresonator detector arrays. These arrays use lumped-element, direct-absorption resonators patterned from titanium nitride films. We will discuss our progress toward constructing a scalable 350 micron pathfinder instrument focusing on fabrication simplicity, multiplexing density, and ultimately a low per-pixel cost

Medical Management and Rehabilitation in the Workplace: Emerging Issues

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45004/1/10926_2004_Article_223619.pd

Preliminary Research on a COVID-19 Test Strategy to Guide Quarantine Interval in University Students

Following COVID-19 exposure, the Centers for Disease Control (CDC) recommends a 10–14-day quarantine for asymptomatic individuals and more recently a 7-day quarantine with a negative PCR test. A university-based prospective cohort study to determine if early polymerase chain reaction (PCR) negativity predicts day 14 negativity was performed. A total of 741 asymptomatic students in quarantine was screened and 101 enrolled. Nasopharyngeal swabs were tested on days 3 or 4, 5, 7, 10, and 14, and the proportion of concordant negative results for each day versus day 14 with a two-sided 95% exact binomial confidence interval was determined. Rates of concordant negative test results were as follows: day 5 vs. day 14 = 45/50 (90%, 95% CI: 78–97%); day 7 vs. day 14 = 47/52 (90%, 95% CI: 79–97%); day 10 vs. day 14 = 48/53 (91%, 95% CI:79–97%), with no evidence of different negative rates between earlier days and day 14 by McNemar’s test, p \u3e 0.05. Overall, 14 of 90 (16%, 95% CI: 9–25%) tested positive while in quarantine, with seven initial positive tests on day 3 or 4, 5 on day 5, 2 on day 7, and none on day 10 or 14. Based on concordance rates between day 7 and 14, we anticipate that 90% (range: 79–97%) of individuals who are negative on day 7 will remain negative on day 14, providing the first direct evidence that exposed asymptomatic students ages 18–44 years in a university setting are at low risk if released from quarantine at 7 days if they have a negative PCR test prior to release. In addition, the 16% positive rate supports the ongoing need to quarantine close contacts of COVID-19 cases