Flow cytometric analysis of activated CD4⁺ T-cells (top) and activated CD8⁺ T-cells (bottom) in the acute (left) and subacute phase (right) in one Legionnaires’ disease patient.

<p>Activated T-cells are defined as CD38+ and HLA-DR+ double positive cells and located in the upper right quadrants of each dot plot. The numbers represent the percentage of cells in the upper right quadrant.</p

Baseline characteristics upon hospitalization of Legionnaires’ disease patients (n = 8).

<p>NA, not applicable; M, male, F, female; Temp, temperature (C) upon presentation to the ED; CRP, C-reactive protein (mg/l); WBC, white blood cell (10⁹/l); lymphocyte count expressed as 10⁹/l; X-ray, chest radiography results upon presentation to the ED; AB, adequate antibiotics within 12 hours after presentation; Duration of symptoms before ED presentation, ICU, Intensive Care Unit admission, LOS, length of stay.</p

CRP levels, WBC counts, absolute neutrophil -, absolute lymphocyte - and lymphocyte subpopulation counts in the acute and subacute phase of Legionnares’ disease (n = 8) and in age and gender matched healthy controls (n = 8).

<p>NA, not applicable; LD, Legionnaires’ disease; CRP, C-reactive protein (mg/l); WBC, white blood cell (10⁹/l); absolute neutrophil count expressed as 10⁹/l; NK, natural killer; absolute lymphocyte count expressed as 10⁹/l; lymphocyte subpopulation counts expressed as 10⁶/l; all data presented as median and range; *p-value Wilcoxon Signed Rank tests for differences in CRP levels, WBC counts, absolute neutrophil, absolute lymphocyte and lymphocyte subpopulation counts between the acute and subacute phase of LD; <b>^#</b>p-value Mann Whitney U tests for differences between the subacute phase of LD and healthy controls.</p

Relative expansion of lymphocyte subpopulations in the subacute phase compared to the acute phase of Legionnaires’ disease.

<p>RE, relative expansion: relative decrease or increase of the different absolute lymphocyte subpopulation counts in the acute versus the subacute phase compared to the relative increase of the absolute lymphocyte count in the same period; all data presented as mean and standard deviation; NK, natural killer cells; *Wilcoxon Signed Rank tests, significant difference p-value <0.05.</p

Baseline characteristics upon presentation at the Emergency Department (n = 395).

<p>COPD, chronic pulmonary obstructive disease; Chronic Obstructive Pulmonary Disease (COPD) was classified using the global initiative for chronic obstructive lung disease classification (GOLD), Hepatic means liver disease related to malignancy, hepatitis, auto-immune liver disease and/or alcoholic liver disease, cardiac means heart disease related to acute coronary syndrome (cardiovascular disease), valvular disease and/or heart failure, renal means renal disease including current renal replacement therapy, cerebrovascular means cerebrovascular disease; n, number; ICU, intensive care unit; data are presented as number (percentage) of patients.</p

Admission levels of the neutrophil-lymphocyte count ratio, white blood cell count (×10e9/l) and C-reactive protein level (mg/l) in community-acquired pneumonia patients classified into five CURB-65 categories (0, 1, 2, 3 and 4+5), (NLCR, neutrophil-lymphocyte count ratio; WBC, white blood cell; Y-axis left CRP, C-reactive protein; Y-axis right) data are presented as mean and SD.

<p>Admission levels of the neutrophil-lymphocyte count ratio, white blood cell count (×10e9/l) and C-reactive protein level (mg/l) in community-acquired pneumonia patients classified into five CURB-65 categories (0, 1, 2, 3 and 4+5), (NLCR, neutrophil-lymphocyte count ratio; WBC, white blood cell; Y-axis left CRP, C-reactive protein; Y-axis right) data are presented as mean and SD.</p

Frequencies of neutrophil-lymphocyte count ratios <10 and ≥10 in subpopulations of patients admitted to the emergency department with community-acquired pneumonia.

<p>NLCR, neutrophil-lymphocyte count ratio; COPD, chronic pulmonary obstructive disease; ICU, intensive care unit; n, number; data are presented as number (percentage) of patients.</p

Infection markers in patients admitted to the Emergency Department with community-acquired pneumonia and subpopulations of patients admitted to the hospital and patients deceased during hospitalization.

<p>WBC, white blood cell; CRP, C-reactive protein; ICU, intensive care unit; NLCR, neutrophil-lymphocyte count ratio; data are presented as mean (SD).</p

Symptom presence in respondents with gastrointestinal symptoms at various age categories.

<p>Symptom presence in respondents with gastrointestinal symptoms at various age categories.</p

Health-related quality of life in respondents with and without gastrointestinal symptoms.

<p>Health-related quality of life in respondents with and without gastrointestinal symptoms.</p