Principal component analysis results for MARS and BMQ-specific for parents and children.

<p>Principal component analysis results for MARS and BMQ-specific for parents and children.</p

Parent reported adherence of their child to their medication [n = 249].

<p>Parent reported adherence of their child to their medication [n = 249].</p

Pearson Product Moment Correlation between MARS, BMQ-specific at Time 1 and Time 2.

<p>Pearson Product Moment Correlation between MARS, BMQ-specific at Time 1 and Time 2.</p

Reliability coefficient.

<p>Reliability coefficient.</p

Demographic characteristics of the participants.

<p>Demographic characteristics of the participants.</p

Test–retest reliability as assessed by ICC for MARS, BMQ-specific Items for parents and children.

<p>Test–retest reliability as assessed by ICC for MARS, BMQ-specific Items for parents and children.</p

Beliefs about medication descriptive statistics.

<p>Beliefs about medication descriptive statistics.</p

Scatter plot showing the four different clusters formed after hierarchical clustering of the ALL study sample using 20th percentile of metabolite levels as cutoff point.

<p>Data for 6-mMPNs and 6-TGNs are the metabolite levels (adjusted per dose/SA). Cluster A (i.e. above 20% cutoff point) was characterized by high levels of 6-TGN levels and 6-mMP levels (adherent patients). Cluster B was characterized by high levels of 6-mMP but with low 6-TGN concentrations, it is expected that those patients in Cluster B had higher TPMT activity than those in cluster A, which would explain the shift in 6-MP metabolism toward 6-mMP production in those patients. Cluster C was characterized by low levels of both 6-mMP levels and 6-TGN (non-adherent patients). Cluster D patients have low levels of 6-mMP levels and high levels of 6-TGN (Lower TPMT activity in patients in Cluster D compared to those in cluster A would explain the shift in 6-MP metabolism toward 6-TG production in those patients).</p

Distribution of the total scores for the MARS questionnaires reported by participating parents and children.

<p>Distribution of the total scores for the MARS questionnaires reported by participating parents and children.</p

Demographic and disease characteristics of the study sample (n = 52)^*.

<p>Demographic and disease characteristics of the study sample (n = 52)^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183119#t002fn001" target="_blank">*</a>}.</p