1 research outputs found
Redox Capacitive Assaying of C‑Reactive Protein at a Peptide Supported Aptamer Interface
Electrochemical
immunosensors offer much in the potential translation
of a lab based sensing capability to a useful “real world”
platform. In previous work we have introduced an impedance-derived
electrochemical capacitance spectroscopic analysis as supportive of
a reagentless means of reporting on analyte target capture at suitably
prepared mixed-component redox-active, antibody-modified interfaces.
Herein we directly integrate receptive aptamers into a redox charging
peptide support in enabling a label-free low picomolar analytical
assay for C-reactive protein with a sensitivity that significantly
exceeds that attainable with an analogous antibody interface