Current Status of Extracorporeal Membrane Oxygenation for Severe Respiratory Failure

Extracorporeal membrane oxygenation (ECMO) for respiratory failure was reviewed. ECMO progressed from laboratory research to initial clinical trials in 1972. Following a decade of clinical research, ECMO is now standard treatment for neonatal respiratory failure refractory to conventional pulmonary support techniques worldwide. The application of neonatal ECMO has been extended with improved outcome to premature and low birth weight infants as well as older children and adults. As of July 1994, 9,258 neonates, 754 pediatric, and 130 adult patients with respiratory failure treated with ECMO were entered in the registry of the Extracorporeal Life Support Organization (ELSO). Overall survival rates were 81 in neonates, 49 in pediatric, and 38 in adult patients. Recently the adult and pediatric populations treated with ECMO have increased rapidly, and the outcome has improved significantly.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73707/1/j.1525-1594.1996.tb00712.x.pd

Review articles : Extracorporeal membrane oxygenation (ECMO): prolonged bedside cardiopulmonary bypass

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68988/2/10.1177_026765919000500402.pd

Oxygen kinetics and the art of physiological monitoring

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31044/1/0000721.pd

Classical and quantum communication without a shared reference frame

We show that communication without a shared reference frame is possible using entangled states. Both classical and quantum information can be communicated with perfect fidelity without a shared reference frame at a rate that asymptotically approaches one classical bit or one encoded qubit per transmitted qubit. We present an optical scheme to communicate classical bits without a shared reference frame using entangled photon pairs and linear optical Bell state measurements.Comment: 4 pages, published versio

Structural investigations of phosphorus-nitrogen compounds. 7. Relationships between physical properties, electron densities, reaction mechanisms and hydrogen-bonding motifs of N3P3Cl(6-n)(NHBut)(n) derivatives

A series of compounds of the N3P3Cl(6-n)(NHBut)n family (where n = 0, 1, 2, 4 and 6) are presented and their molecular parameters are related to trends in physical properties, which provides insight into a potential reaction mechanism for nucleophilic substitution. The crystal structures of N3P3Cl5(NHBut) and N3P3Cl2(NHBut)4 have been determined at 120K and those of N3P3Cl6 and N3P3Cl4(NHBut)2 have been re-determined at 120K. These are compared with the known structure of N3P3(NHBut)6 studied at 150K. Trends in molecular parameters (phosphazene ring, P-Cl & P-N(HBut) distances, PCl2 angles and endo- and exo-cyclic phosphazene ring parameters) across the series are observed. Hydrogen-bonding motifs are identified, characterised and compared. Both the molecular and hydrogen bonding parameters are related to the electron distribution in bonds and the derived basicities of the cyclophosphazene series of compounds. These findings provide evidence for a proposed mechanism for nucleophilic substitution at a phosphorus site bearing a PCl(NHBut) moiety

Quantum communication using a bounded-size quantum reference frame

Typical quantum communication schemes are such that to achieve perfect decoding the receiver must share a reference frame with the sender. Indeed, if the receiver only possesses a bounded-size quantum token of the sender's reference frame, then the decoding is imperfect, and we can describe this effect as a noisy quantum channel. We seek here to characterize the performance of such schemes, or equivalently, to determine the effective decoherence induced by having a bounded-size reference frame. We assume that the token is prepared in a special state that has particularly nice group-theoretic properties and that is near-optimal for transmitting information about the sender's frame. We present a decoding operation, which can be proven to be near-optimal in this case, and we demonstrate that there are two distinct ways of implementing it (corresponding to two distinct Kraus decompositions). In one, the receiver measures the orientation of the reference frame token and reorients the system appropriately. In the other, the receiver extracts the encoded information from the virtual subsystems that describe the relational degrees of freedom of the system and token. Finally, we provide explicit characterizations of these decoding schemes when the system is a single qubit and for three standard kinds of reference frame: a phase reference, a Cartesian frame (representing an orthogonal triad of spatial directions), and a reference direction (representing a single spatial direction).Comment: 17 pages, 1 figure, comments welcome; v2 published versio

Entanglement under restricted operations: Analogy to mixed-state entanglement

We show that the classification of bi-partite pure entangled states when local quantum operations are restricted yields a structure that is analogous in many respects to that of mixed-state entanglement. Specifically, we develop this analogy by restricting operations through local superselection rules, and show that such exotic phenomena as bound entanglement and activation arise using pure states in this setting. This analogy aids in resolving several conceptual puzzles in the study of entanglement under restricted operations. In particular, we demonstrate that several types of quantum optical states that possess confusing entanglement properties are analogous to bound entangled states. Also, the classification of pure-state entanglement under restricted operations can be much simpler than for mixed-state entanglement. For instance, in the case of local Abelian superselection rules all questions concerning distillability can be resolved.Comment: 10 pages, 2 figures; published versio

Extracorporeal life support in critical care medicine

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28857/1/0000692.pd

The Molecular Adsorbents Recycling System as a Liver Support System Based on Albumin Dialysis: A Summary of Preclinical Investigations, Prospective, Randomized, Controlled Clinical Trial, and Clinical Experience from 19 Centers

Artificial liver support aims to prolong survival time of patients with liver failure by detoxification. Albumin as a molecular adsorbent in dialysis solution is capable of attracting even tightly albumin-bound toxins from blood into the dialysate if a specific dialysis membrane is used and if the albumin's binding sites are on-line-purified by a sorbent/dialysis-based recycling system (i.e., molecular adsorbents recycling system, or MARS). The MARS technology has been shown to remove water-soluble and albumin-bound toxins and to provide renal support in case of renal failure. Fourteen centers have reported that MARS treatment improved mental status of patients with liver failure and hepatic encephalopathy. In treating liver failure and cholestasis, MARS was associated with hemodynamic stabilization, improvement of hepatic and kidney function, and disappearance of pruritus. In hepatic failure and hepatorenal syndrome, a prospective, randomized, controlled trial of MARS treatment was able to prolong survival time significantly. MARS has been used in 26 patients with acute liver failure or primary graft dysfunction. Nineteen centers reporting on 103 patients have shown that MARS treatment is safe, easy to handle, feasible, and effective.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73869/1/j.1525-1594.2002.06822.x.pd

Dialogue Concerning Two Views on Quantum Coherence: Factist and Fictionist

A controversy that has arisen many times over in disparate contexts is whether quantum coherences between eigenstates of certain quantities are fact or fiction. We present a pedagogical introduction to the debate in the form of a hypothetical dialogue between proponents from each of the two camps: a factist and a fictionist. A resolution of the debate can be achieved, we argue, by recognizing that quantum states do not only contain information about the intrinsic properties of a system but about its extrinsic properties as well, that is, about its relation to other systems external to it. Specifically, the coherent quantum state of the factist is the appropriate description of the relation of the system to one reference frame, while the incoherent quantum state of the fictionist is the appropriate description of the relation of the system to another, uncorrelated, reference frame. The two views, we conclude, are alternative but equally valid paradigms of description.Comment: 14 pages, Contribution to the Int. J. of Quant. Info. issue dedicated to the memory of Asher Peres; v2 updated summary and critique of prior literatur