42 research outputs found
Boceprevir Plus Peginterferon Alfa-2a/Ribavirin in Treatment-Naïve Hepatitis C Virus Genotype 1 Patients: International Phase IIIb/IV TriCo Trial
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Relationship between alanine aminotransferase (ALT)/upper limit of normal (ULN) and sustained virologic response (SVR).
<p>Short vertical lines indicate the number of patients with SVR (black lines) and no SVR (grey lines). Open circles represent probability of SVR according to the GAM analysis. Closed circles represent empirical probability for midpoints of deciles. ALT/ULN = patients' ALT divided by the ULN for the local laboratory</p
Relationship between age and sustained virologic response (SVR).
<p>Short vertical lines indicate the number of patients with SVR (black lines) and no SVR (grey lines). Open circles represent probability of SVR according to the GAM analysis. Closed circles represent empirical probability for midpoints of deciles.</p
Sustained virologic response and relapse rates in treatment-naive Caucasian patients with HCV genotype 3 by baseline prediction score.
<p>A) Development cohort; B) Validation cohort SVR = sustained virologic response 24 weeks post-treatment. <sup>a</sup> 73 patients did not have a score and were omitted; of these, 46 (63.0%) achieved SVR. <sup>b</sup> Patients with end-of-treatment response and sufficient follow-up.</p
Scoring system for predictive baseline characteristics.
<p>Scoring system for predictive baseline characteristics.</p
Baseline demographic and disease characteristics.
<p>HCV, hepatitis C virus; <i>IL28B</i>, interleukin 28B; RBV, ribavirin; TVR, telaprevir.</p
Subgroup analysis for SVR12.
<p>CI, confidence interval; HCV, hepatitis C virus; <i>IL28B</i>, interleukin 28B; RBV, ribavirin; SVR12, sustained virologic response at week 12 post-treatment follow-up; TVR, telaprevir.</p
Patient selection for the validation cohort.
<p>Patient selection for the validation cohort.</p
Summary of key efficacy endpoints.
<p>CI, confidence interval; EOTR, end-of-treatment response; eRVR, extended rapid virologic response; mITT, modified intent-to-treat; RBV, ribavirin; RVR, rapid virologic response; SVR12, sustained virologic response at week 12 post-treatment follow-up; TVR, telaprevir.</p