On the Prevalence of Linear versus Nonlinear Thinking in Undergraduate Business Education: A Lot of Rhetoric, Not Enough Evidence

The purpose of this research is to examine the undergraduate learning goals of business programs and determine if these goals are skewed in the directions posed by critics of undergraduate business education. The underlying theme of many critiques is that nonlinear-thinking processes are underrepresented in undergraduate business curricula, whereas linear-thinking processes are overrepresented. The learning goals of 208 Association to Advance Collegiate Schools of Business International-accredited business programs were coded into two goal categories: linear thinking and nonlinear thinking. The results support the contention that nonlinear-thinking processes have a lesser presence in the typical undergraduate business program’s curriculum. These findings are consistent across research and teaching universities

GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord

Axonal regeneration within the CNS fails due to the growth-inhibitory environment and the limited intrinsic growth capacity of injured neurons. Injury to DRG peripheral axons induces expression of growth associated genes including members of the glial-derived neurotrophic factor (GDNF) signaling pathway and “pre-conditions” the injured cells into an active growth state, enhancing growth of their centrally projecting axons. Here, we show that pre-conditioning DRG neurons prior to culturing increased neurite outgrowth, which was further enhanced by GDNF in a bell-shaped growth response curve. In vivo, GDNF delivered directly to DRG cell bodies facilitated the pre-conditioning effect, further enhancing axonal regeneration beyond spinal cord lesions. Consistent with the in vitro results, the in vivo effect was seen only at low GDNF concentrations. We conclude that peripheral nerve injury upregulates GDNF signaling pathway components and that exogenous GDNF treatment selectively promotes axonal growth of injury-primed sensory neurons in a concentration-dependent fashion

Placing the library at the heart of plagiarism prevention: The University of Bradford experience.

yesPlagiarism is a vexed issue for Higher Education, affecting student transition, retention and attainment. This paper reports on two initiatives from the University of Bradford library aimed at reducing student plagiarism. The first initiative is an intensive course for students who have contravened plagiarism regulations. The second course introduces new students to the concepts surrounding plagiarism with the aim to prevent plagiarism breaches. Since the Plagiarism Avoidance for New Students course was introduced there has been a significant drop in students referred to the disciplinary programme. This paper discusses the background to both courses and the challenges of implementation

Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons

Dopa-responsive dystonia (DRD) and Parkinson’s disease (PD) are movement disorders caused by the dysfunction of nigrostriatal dopaminergic neurons. Identifying druggable pathways and biomarkers for guiding therapies is crucial due to the debilitating nature of these disorders. Recent genetic studies have identified variants of GTP cyclohydrolase-1 (GCH1), the rate-limiting enzyme in tetrahydrobiopterin (BH4) synthesis, as causative for these movement disorders. Here, we show that genetic and pharmacological inhibition of BH4 synthesis in mice and human midbrain-like organoids accurately recapitulates motor, behavioral and biochemical characteristics of these human diseases, with severity of the phenotype correlating with extent of BH4 deficiency. We also show that BH4 deficiency increases sensitivities to several PD-related stressors in mice and PD human cells, resulting in worse behavioral and physiological outcomes. Conversely, genetic and pharmacological augmentation of BH4 protects mice from genetically- and chemically induced PD-related stressors. Importantly, increasing BH4 levels also protects primary cells from PD-affected individuals and human midbrain-like organoids (hMLOs) from these stressors. Mechanistically, BH4 not only serves as an essential cofactor for dopamine synthesis, but also independently regulates tyrosine hydroxylase levels, protects against ferroptosis, scavenges mitochondrial ROS, maintains neuronal excitability and promotes mitochondrial ATP production, thereby enhancing mitochondrial fitness and cellular respiration in multiple preclinical PD animal models, human dopaminergic midbrain-like organoids and primary cells from PD-affected individuals. Our findings pinpoint the BH4 pathway as a key metabolic program at the intersection of multiple protective mechanisms for the health and function of midbrain dopaminergic neurons, identifying it as a potential therapeutic target for PD

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

Chronic pain is highly variable between individuals, as is the response to analgesics. Although much of the variability in chronic pain and analgesic response is heritable, an understanding of the genetic determinants underlying this variability is rudimentary1. Here we show that variation within the coding sequence of the gene encoding the P2X7 receptor (P2X7R) affects chronic pain sensitivity in both mice and humans. P2X7Rs, which are members of the family of ionotropic ATP-gated receptors, have two distinct modes of function: they can function through their intrinsic cationic channel or by forming nonselective pores that are permeable to molecules with a mass of up to 900 Da2,3. Using genome-wide linkage analyses, we discovered an association between nerve-injury–induced pain behavior (mechanical allodynia) and the P451L mutation of the mouse P2rx7 gene, such that mice in which P2X7Rs have impaired pore formation as a result of this mutation showed less allodynia than mice with the pore-forming P2rx7 allele. Administration of a peptide corresponding to the P2X7R C-terminal domain, which blocked pore formation but not cation channel activity, selectively reduced nerve injury and inflammatory allodynia only in mice with the pore-forming P2rx7 allele. Moreover, in two independent human chronic pain cohorts, a cohort with pain after mastectomy and a cohort with osteoarthritis, we observed a genetic association between lower pain intensity and the hypofunctional His270 (rs7958311) allele of P2RX7. Our findings suggest that selectively targeting P2X7R pore formation may be a new strategy for individualizing the treatment of chronic pain

Oral Communication Skills: Are the Priorities of the Workplace and AACSB-Accredited Business Programs Aligned?

Our purpose in this study was to assess the alignment of oral communication (OC) skills between the workplace and business schools. Drawing on theory related to communication interactivity, we differentiate three types of OC: presenting, listening, and conversing. In reviewing prior empirical research, we found that listening was the most important of these OC types in the workplace, followed by conversing and presenting, respectively. We review and analyze learning goals of U.S. undergraduate business programs accredited by the Association to Advance Collegiate Schools of Business. We found that 76% of the business programs had an oral presentation learning goal, 22%, a conversing goal, and 11%, a listening goal. Our research reveals a misalignment between the OC skills needed in the workplace compared to those emphasized in business curricula. We discuss potential reasons for the misalignment and offer suggestions for closing the gap

Another Perspective on MBA Program Alignment: An Investigation of Learning Goals

In recent AMLE issues, Rubin and Dierdorff (2009, 2011) reported a marked misalignment between the competencies needed for managerial effectiveness and those that are being taught in required MBA courses of AACSB-accredited business programs. We extend their work by investigating the pervasiveness of this curricular misalignment. We consider whether the learning goals of MBA programs are also misaligned with key managerial competencies. Through an analysis of the learning goals of 250 MBA programs, we found that learning goals are mostly in alignment with the competencies that lead to managerial success. Explanations for the conflicting findings between our learning goal study and Rubin and Dierdorff’s (2009) study are provided, along with recommendations for reducing curricular gaps and suggestions for future research

Does being positive work in a mediterranean collectivist culture? Relationship of core self-evaluations to job satisfaction, life satisfaction, and commitment

The vast majority of the core self-evaluations (CSE) studies has been conducted in Western cultures. In an attempt to extend this research into a different culture, the present study tested the factor structure of a Turkish version of the CSE scale and examined the relationship of CSE to job satisfaction, life satisfaction, and affective commitment. Data were collected in student (n = 216) and field samples (n = 321). The results confirmed the proposed one-factor structure of the Turkish version of the CSE scale as well as its convergent and discriminant validity. CSE (measured in time period 1) was significantly related to job satisfaction, life satisfaction, and affective commitment (measured in time period 2 which was three months later). The authors concluded that the CSE is predictive of key career-related outcomes in Turkey’s collectivist culture