Study selection flowchart for review.

<p>Study selection flowchart for review.</p

Forest plot of meta-analysis of weighted mean difference in IQ between meningitis survivors and controls by organism.

<p>Abbreviations: <i>Haemophilus influenzae</i> b (Hib), <i>Streptococcus pneumoniae</i> (SP) <i>Neisseria meningitides</i> (NM), group B streptococcus (GBS)</p

Forest plot of meta-analysis of mean IQ estimates by organism.

<p>Abbreviations: <i>Haemophilus influenzae</i> b (Hib), <i>Streptococcus pneumoniae</i> (SP) <i>Neisseria meningitides</i> (NM), group B streptococcus (GBS)</p

Developmental delay (DD) by organism and developmental domain in CC and cohort studies.

<p>Developmental delay (DD) by organism and developmental domain in CC and cohort studies.</p

Full scale IQ: Mean IQ and proportions with low IQ (≤70) by organism.

<p>Full scale IQ: Mean IQ and proportions with low IQ (≤70) by organism.</p

Forest plot of mean difference in Verbal and Performance IQ between meningitis survivors and controls by organism.

<p>Panel A shows Verbal IQ and Panel B shows Performance IQ. Abbreviations: <i>Haemophilus influenzae</i> b (Hib), <i>Streptococcus pneumoniae</i> (SP) <i>Neisseria meningitides</i> (NM), group B streptococcus (GBS); weighted mean difference (WMD)</p

Forest plot of relative risk of low IQ (IQ<70) in meningitis survivors compared with controls by organism.

<p>Abbreviations: <i>Haemophilus influenzae</i> b (Hib), <i>Streptococcus pneumoniae</i> (SP) <i>Neisseria meningitides</i> (NM), group B streptococcus (GBS)</p

Protocol on establishing a prospective enhanced surveillance of vaccine preventable diseases in residential aged care facilities in Central Queensland, Australia: an observational study

Introduction Infectious diseases are a major cause of mortality and morbidity among the highly vulnerable occupants of residential aged care facilities (RACFs). The burden of vaccine preventable diseases (VPDs) among RACFs residents is mostly unknown and there is a lack of quality data from population-based prospective VPD surveillance in RACFs. The increasing burden of emerging and existing VPDs (eg, COVID-19, influenza, pneumococcal, pertussis and varicella-zoster) necessitates the establishment of an active enhanced surveillance system to provide real-time evidence to devise strategies to reduce the burden of VPDs in RACFs. Method and analysis This study proposes a prospective active enhanced surveillance that will be implemented in RACFs across the Central Queensland (CQ) region. The study aims to measure the burden, identify aetiologies, risk factors, predictors of severe outcomes (eg, hospitalisations, mortality) and impact of the existing National Immunization Program (NIP) funded vaccines in preventing VPDs in this vulnerable population. CQ Public Health Unit (CQPHU) will implement the active surveillance by collecting demographic, clinical, pathological, diagnostic, therapeutic and clinical outcome data from the RACFs based on predefined selection criteria and case report forms as per routine public health practices. Descriptive statistics, univariate and multivariate regression analysis will be conducted to identify the predictors of morbidity and clinical outcomes following infection

Number of incident cases (confirmed+probable) per 100 people (residents & staff) in T and T&P ACFs.

<p>Number of incident cases (confirmed+probable) per 100 people (residents & staff) in T and T&P ACFs.</p

Epidemic curve for the influenza outbreak in Treatment only (“T”) Aged Care Facility B (confirmed and probable cases, amongst residents and staff).

<p>Epidemic curve for the influenza outbreak in Treatment only (“T”) Aged Care Facility B (confirmed and probable cases, amongst residents and staff).</p