Measurements at low energies of the polarization-transfer coefficient Kyy' for the reaction 3H(p,n)3He at 0 degrees

Measurements of the transverse polarization coefficient Kyy' for the reaction 3H(p,n)3He are reported for outgoing neutron energies of 1.94, 5.21, and 5.81 MeV. This reaction is important both as a source of polarized neutrons for nuclear physics experiments, and as a test of theoretical descriptions of the nuclear four-body system. Comparison is made to previous measurements, confirming the 3H(p,n)3He reaction can be used as a polarized neutron source with the polarization known to an accuracy of approximately 5%. Comparison to R-matrix theory suggests that the sign of the 3F3 phase-shift parameter is incorrect. Changing the sign of this parameter dramatically improves the agreement between theory and experiment.Comment: 12 pages, RevTeX, 5 eps figures, submitted to Phys. Rev.

Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations.

Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotemporal dementia. Most pathogenic GRN mutations result in progranulin haploinsufficiency, which is thought to cause frontotemporal dementia in GRN mutation carriers. Progranulin haploinsufficiency may drive frontotemporal dementia pathogenesis by disrupting lysosomal function, as patients with GRN mutations on both alleles develop the lysosomal storage disorder neuronal ceroid lipofuscinosis, and frontotemporal dementia patients with GRN mutations (FTD-GRN) also accumulate lipofuscin. The specific lysosomal deficits caused by progranulin insufficiency remain unclear, but emerging data indicate that progranulin insufficiency may impair lysosomal sphingolipid-metabolizing enzymes. We investigated the effects of progranulin insufficiency on sphingolipid-metabolizing enzymes in the inferior frontal gyrus of FTD-GRN patients using fluorogenic activity assays, biochemical profiling of enzyme levels and posttranslational modifications, and quantitative neuropathology. Of the enzymes studied, only β-glucocerebrosidase exhibited impairment in FTD-GRN patients. Brains from FTD-GRN patients had lower activity than controls, which was associated with lower levels of mature β-glucocerebrosidase protein and accumulation of insoluble, incompletely glycosylated β-glucocerebrosidase. Immunostaining revealed loss of neuronal β-glucocerebrosidase in FTD-GRN patients. To investigate the effects of progranulin insufficiency on β-glucocerebrosidase outside of the context of neurodegeneration, we investigated β-glucocerebrosidase activity in progranulin-insufficient mice. Brains from Grn-/- mice had lower β-glucocerebrosidase activity than wild-type littermates, which was corrected by AAV-progranulin gene therapy. These data show that progranulin insufficiency impairs β-glucocerebrosidase activity in the brain. This effect is strongest in neurons and may be caused by impaired β-glucocerebrosidase processing

Neutron Resonance Spectroscopy of 106Pd, and 108Pd from 20–2000 eV

Parity nonconserving asymmetries have been measured in p-wave resonances of 106Pd and 108Pd. The data analysis requires knowledge of the neutron resonance parameters. Transmission and capture γ-ray yields were measured for En=20–2000 eV with the time-of-flight method at the Los Alamos Neutron Science Center (LANSCE). A total of 28 resonances in 106Pd and 32 resonances in 108Pd were studied. The resonance parameters for 106Pd are new for all except one resonance. In 108Pd six new resonances were observed and the precision improved for many of the resonance parameters. A Bayesian analysis was used to assign orbital angular momentum for the resonances studied

Parity Nonconservation in 106Pd and 108Pd Neutron Resonances

Parity nonconservation (PNC) has been studied in the neutron p-wave resonances of 106Pd and 108Pd in the energy range of 20 to 2000 eV. Longitudinal asymmetries in p-wave capture cross sections are measured using longitudinally polarized neutrons incident on ∼20-g metal-powder targets at LANSCE. A CsI γ-ray detector array measures capture cross section asymmetries as a function of neutron energy which is determined by the neutron time-of-flight method. A total of 21 p-wave resonances in 106Pd and 21 p-wave resonances in 108Pd were studied. One statistically significant PNC effect was observed in106Pd, and no effects were observed in 108Pd. For 106Pd a weak spreading width of Γw=34-28+47×10-7 eV was obtained. For 108Pd an upper limit on the weak spreading width of Γw\u3c12×10-7 eV was determined at the 68% confidence level

Parity Violation in Neutron Resonances in 107,109Ag

Parity nonconservation (PNC) was studied in p-wave resonances in Ag by measuring the helicity dependence of the neutron total cross section. Transmission measurements on natural Ag were performed in the energy range 32 to 422 eV with the time-of-flight method at the Manuel Lujan Neutron Scattering Center at Los Alamos National Laboratory. A total of 15 p-wave neutron resonances were studied in 107Ag and ninep-wave resonances in 109Ag. Statistically significant asymmetries were observed for eight resonances in 107Ag and for four resonances in109Ag. An analysis treating the PNC matrix elements as random variables yields a weak spreading width of Γw=(2.67-1.21+2.65)×10-7 eV for107Ag and Γw=(1.30-0.74+2.49)×10-7 eV for 109Ag

Parity Violation in Neutron Resonances of Palladium

Parity violation in p-wave neutron resonances of the palladium isotopes 104, 105, 106, and 108 has been measured by transmission of a longitudinally polarized neutron beam through a natural palladium target. The measurements were performed at the pulsed spallation neutron source of Los Alamos Neutron Science Center. The rms weak interaction matrix elements and the corresponding spreading widths were determined for 104 Pd, 105 Pd, and 106 P

Neutron Resonance Spectroscopy of 103Rh from 30 eV to 2 keV

Neutron resonances in 103Rh have been measured for neutron energies from 30 to 2000 eV using the time-of-flight method and the (n,γ) reaction. The rhodium resonance spectroscopy is essential for the analysis of parity violation measurements recently performed on neutron resonances in 103Rh. Neutron scattering and radiative widths were determined, and orbital angular momentum assignments made with a Bayesian analysis. The s-wave and p-wave strength functions and average level spacings were determined

Parity Violation in Neutron Resonances of 103Rh

Parity nonconservation (PNC) was studied in p-wave neutron resonances of 103Rh in the neutron energy range 30 to 490 eV. The helicity dependence of the neutron total cross section of rhodium was determined by capture measurements with the time-of-flight method at the Manuel Lujan Neutron Scattering Center at the Los Alamos National Laboratory. A total of 32 p-wave resonances were studied and statistically significant longitudinal asymmetries were observed for resonances at En=44.5, 110.8, 321.6, and 432.9 eV. A statistical analysis treating the PNC matrix elements as random variables yields a weak spreading widthΓw=(1.42-0.59+1.21)×10-7eV

Does Self-Compassion Protect Adolescents from Stress?

The aim of this study was to determine whether adolescents who were high in self-compassion self-reported different levels of emotional wellbeing than adolescents who were low in self-compassion, and to determine whether those high in self-compassion responded differently under a lab social stressor than those low in self-compassion. In a lab setting, participants (age 13–18; n = 28) completed the Trier Social Stress Test (TSST) and physiological stress was assessed via salivary cortisol, heart rate, blood pressure, and heart rate variability at baseline, during the TSST, and during recovery. After completing the lab protocol, an email was sent to participants that provided a link to an online survey which was composed of emotional wellbeing measures including perceived stress, life satisfaction, positive and negative affect. After conducting repeated measure ANOVAS to determine that the TSST induced a significant stress response, the sample was split at the median of self-compassion. T tests were conducted to determine meaningful differences (Hedges’ g > .20) between the groups. Findings indicated that those in the high self-compassion group (≥the median) self-reported greater emotional wellbeing than those in the low self-compassion group (<the median). Overall, those in the high self-compassion group also had a lower physiologic stress response when exposed to the TSST than those in the low self-compassion group. Regression analyses were also conducted; baseline self-compassion predicted self-reported emotional wellbeing, but did not predict physiological response to the TSST. Findings support the potential buffering effect that self-compassion may have in protecting adolescents from social stressors; yet more research needs to be conducted in larger samples to confirm and replicate these findings