Signatures of Spherical Compactification at the LHC

TeV-scale extra dimensions may play an important role in electroweak or supersymmetry breaking. We examine the phenomenology of such dimensions, compactified on a sphere $S^n$, $n \geq 2$, and show that they possess distinct features and signatures. For example, unlike flat toroidal manifolds, spheres do not trivially allow fermion massless modes. Acceptable phenomenology then generically leads to "non-universal" extra dimensions with "pole-localized" 4-$d$ fermions; the bosonic fields can be in the bulk. Due to spherical symmetry, some Kaluza-Klein (KK) modes of bulk gauge fields are either stable or extremely long-lived, depending on the graviton KK spectrum. Using precision electroweak data, we constrain the lightest gauge field KK modes to lie above $\simeq 4$ TeV. We show that some of these KK resonances are within the reach of the LHC in several different production channels. The models we study can be uniquely identified by their collider signatures.Comment: 21 pages, 5 fig

MENGA: a new comprehensive tool for the integration of neuroimaging data and the Allen human brain transcriptome atlas

Brain-wide mRNA mappings offer a great potential for neuroscience research as they can provide information about system proteomics. In a previous work we have correlated mRNA maps with the binding patterns of radioligands targeting specific molecular systems and imaged with positron emission tomography (PET) in unrelated control groups. This approach is potentially applicable to any imaging modality as long as an efficient procedure of imaging-genomic matching is provided. In the original work we considered mRNA brain maps of the whole human genome derived from the Allen human brain database (ABA) and we performed the analysis with a specific region-based segmentation with a resolution that was limited by the PET data parcellation. There we identified the need for a platform for imaging-genomic integration that should be usable with any imaging modalities and fully exploit the high resolution mapping of ABA dataset.In this work we present MENGA (Multimodal Environment for Neuroimaging and Genomic Analysis), a software platform that allows the investigation of the correlation patterns between neuroimaging data of any sort (both functional and structural) with mRNA gene expression profiles derived from the ABA database at high resolution.We applied MENGA to six different imaging datasets from three modalities (PET, single photon emission tomography and magnetic resonance imaging) targeting the dopamine and serotonin receptor systems and the myelin molecular structure. We further investigated imaging-genomic correlations in the case of mismatch between selected proteins and imaging targets

Bosonic Seesaw in the Unparticle Physics

Recently, conceptually new physics beyond the Standard Model has been proposed by Georgi, where a new physics sector becomes conformal and provides "unparticle" which couples to the Standard Model sector through higher dimensional operators in low energy effective theory. Among several possibilities, we focus on operators involving the (scalar) unparticle, Higgs and the gauge bosons. Once the Higgs develops the vacuum expectation value (VEV), the conformal symmetry is broken and as a result, the mixing between the unparticle and the Higgs boson emerges. In this paper, we consider a natural realization of bosonic seesaw in the context of unparticle physics. In this framework, the negative mass squared or the electroweak symmetry breaking vacuum is achieved as a result of mass matrix diagonalization. In the diagonalization process, it is important to have zero value in the (1,1)-element of the mass matrix. In fact, the conformal invariance in the hidden sector can actually assure the zero of that element. So, the bosonic seesaw mechanism for the electroweak symmetry breaking can naturally be understood in the framework of unparticle physics.Comment: 5 pages, no figure; added one more referenc

On Direct Verification of Warped Hierarchy-and-Flavor Models

We consider direct experimental verification of warped models, based on the Randall-Sundrum (RS) scenario, that explain gauge and flavor hierarchies, assuming that the gauge fields and fermions of the Standard Model (SM) propagate in the 5D bulk. Most studies have focused on the bosonic Kaluza Klein (KK) signatures and indicate that discovering gauge KK modes is likely possible, yet challenging, while graviton KK modes are unlikely to be accessible at the LHC, even with a luminosity upgrade. We show that direct evidence for bulk SM fermions, {\it i.e.} their KK modes, is likely also beyond the reach of a luminosity-upgraded LHC. Thus, neither the spin-2 KK graviton, the most distinct RS signal, nor the KK SM fermions, direct evidence for bulk flavor, seem to be within the reach of the LHC. We then consider hadron colliders with $\sqrt{s} =$ 21, 28, and 60 TeV. We find that discovering the first KK modes of SM fermions and the graviton typically requires the Next Hadron Collider (NHC) with $\sqrt{s} \approx 60$ TeV and ${\cal O}(1)$ ab$^{-1}$ of integrated luminosity. If the LHC yields hints of these warped models, establishing that Nature is described by them, or their 4D CFT duals, requires an NHC-class machine in the post-LHC experimental program.Comment: Revtex4, 21 pages, 11 figure

Collider Production of TeV Scale Black Holes and Higher-Curvature Gravity

We examine how the production of TeV scale black holes at colliders is influenced by the presence of Lovelock higher-curvature terms in the action of models with large extra dimensions. Such terms are expected to arise on rather general grounds, e.g., from string theory and are often used in the literature to model modifications to the Einstein-Hilbert action arising from quantum and/or stringy corrections. While adding the invariant which is quadratic in the curvature leads to quantitative modifications in black hole properties, cubic and higher invariants are found to produce significant qualitative changes, e.g., classically stable black holes. We use these higher-order curvature terms to construct a toy model of the black hole production cross section threshold. For reasonable parameter values we demonstrate that detailed measurements of the properties of black holes at future colliders will be highly sensitive to the presence of the Lovelock higher-order curvature terms.Comment: 37 pages, 11 figures, references adde

Invariant NKT cells and rheumatic disease: Focus on primary sjogren syndrome

Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology. Invariant natural killer (NK) T cells (iNKT) are a T-cell subset able to recognize glycolipid antigens. Their function remains unclear, but studies have pointed out their ability to modulate the immune system through the promotion of specific cytokine milieu. In this review, we discussed the possible role of iNKT in pSS development, as well as their implications as future markers of disease activity

Lessons and Prospects from the pMSSM after LHC Run I: Neutralino LSP

We study SUSY signatures at the 7, 8 and 14 TeV LHC employing the 19-parameter, R-Parity conserving p(henomenological)MSSM, in the scenario with a neutralino LSP. Our results were obtained via a fast Monte Carlo simulation of the ATLAS SUSY analysis suite. The flexibility of this framework allows us to study a wide variety of SUSY phenomena simultaneously and to probe for weak spots in existing SUSY search analyses. We determine the ranges of the sparticle masses that are either disfavored or allowed after the searches with the 7 and 8 TeV data sets are combined. We find that natural SUSY models with light squarks and gluinos remain viable. We extrapolate to 14 TeV with both 300 fb$^{-1}$ and 3 ab$^{-1}$ of integrated luminosity and determine the expected sensitivity of the jets + MET and stop searches to the pMSSM parameter space. We find that the high-luminosity LHC will be powerful in probing SUSY with neutralino LSPs and can provide a more definitive statement on the existence of natural Supersymmetry.Comment: 41 pages, 27 figures. arXiv admin note: substantial text overlap with arXiv:1307.844

Single WRW_R Production in e−e−e^-e^- Collisions at the NLC

Single $W_R$ production in $e^-e^-$ collisions at the NLC can be used to probe the Majorana nature of the heavy neutrinos present in the Left-Right Symmetric Model below the kinematic threshold for their direct production. For colliders in the $\sqrt {s}=1-1.5$ TeV range, typical cross sections of order $1-10 fb$ are obtained, depending on the specific choice of model parameters. Backgrounds arising from Standard Model processes are shown to be small. This analysis greatly extends the kinematic range of previous studies wherein the production of an on-shell, like-sign pair of $W_R$'s at the NLC was considered.Comment: 13pp, 3 figures (available on request), LaTex, SLAC-PUB-647

Chaos in temperature in the Sherrington-Kirkpatrick model

We prove the existence of chaos in temperature in the Sherringhton-Kirkpatrick model. The effect is exceedingly small, namely of the ninth order in perturbation theory. The equations describing two systems at different temperatures constrained to have a fixed overlap are studied analytically and numerically, yielding information about the behaviour of the overlap distribution function $P_{T_1,T_2}(q)$ in finite-size systems.Comment: REVTEX, 6 pages, 2 figure