Museums as disseminators of niche knowledge: Universality in accessibility for all

Accessibility has faced several challenges within audiovisual translation Studies and gained great opportunities for its establishment as a methodologically and theoretically well-founded discipline. Initially conceived as a set of services and practices that provides access to audiovisual media content for persons with sensory impairment, today accessibility can be viewed as a concept involving more and more universality thanks to its contribution to the dissemination of audiovisual products on the topic of marginalisation. Against this theoretical backdrop, accessibility is scrutinised from the perspective of aesthetics of migration and minorities within the field of the visual arts in museum settings. These aesthetic narrative forms act as modalities that encourage the diffusion of ‘niche’ knowledge, where processes of translation and interpretation provide access to all knowledge as counter discourse. Within this framework, the ways in which language is used can be considered the beginning of a type of local grammar in English as lingua franca for interlingual translation and subtitling, both of which ensure access to knowledge for all citizens as a human rights principle and regardless of cultural and social differences. Accessibility is thus gaining momentum as an agent for the democratisation and transparency of information against media discourse distortions and oversimplifications

Role of subclinical gut inflammation in the pathogenesis of spondyloarthritis

Subclinical gut inflammation occurring in patients affected by spondyloarthritis (SpA) is correlated with the severity of spine inflammation. Several evidences indicate that dysbiosis occurs in SpA, and that may modulate intestinal permeability and intestinal immune responses. The presence of intestinal dysbiosis is accompanied in SpA patients with the presence of zonulin-dependent alterations of gut-epithelial and gut-vascular barriers. The leakage of epithelial and endothelial surface layers is followed by the translocation of bacterial products, such as lipopolysaccharide and intestinal fatty acid binding protein, in the systemic circulation. These bacterial products may downregulate the expression of CD14 on circulating monocytes leading to an "anergic" phenotype. In the gut, IL-23 may induce the expansion of innate immune cells such as mucosal-associated invariant T cells, γδ T cells, and innate lymphoid cells of group 3 that through the interaction with MAdCAM1 may recirculate form the gut to the sites of SpA active inflammation. On the basis of these findings, gut inflammation observed in SpA patient seems to be not only an epiphenomenon of the on going systemic inflammatory process but may also represent the base camp in which inflammatory cells are activated and from whom they shuttle

On the Parisi-Toulouse hypothesis for the spin glass phase in mean-field theory

We consider the spin-glass phase of the Sherrington-Kirkpatrick model in the presence of a magnetic field. The series expansion of the Parisi function $q(x)$ is computed at high orders in powers of $\tau=T_c-T$ and $H$. We find that none of the Parisi-Toulouse scaling hypotheses on the $q(x)$ behavior strictly holds, although some of them are violated only at high orders. The series is resummed yielding results in the whole spin-glass phase which are compared with those from a numerical evaluation of the $q(x)$. At the high order considered, the transition turns out to be third order on the Almeida-Thouless line, a result which is confirmed rigorously computing the expansion of the solution near the line at finite $\tau$. The transition becomes smoother for infinitesimally small field while it is third order at strictly zero field.Comment: 6 pages, 2 figure

Fragmentation paths in dynamical models

We undertake a quantitative comparison of multi-fragmentation reactions, as modeled by two different approaches: the Antisymmetrized Molecular Dynamics (AMD) and the momentum-dependent stochastic mean-field (SMF) model. Fragment observables and pre-equilibrium (nucleon and light cluster) emission are analyzed, in connection to the underlying compression-expansion dynamics in each model. Considering reactions between neutron-rich systems, observables related to the isotopic properties of emitted particles and fragments are also discussed, as a function of the parametrization employed for the isovector part of the nuclear interaction. We find that the reaction path, particularly the mechanism of fragmentation, is different in the two models and reflects on some properties of the reaction products, including their isospin content. This should be taken into account in the study of the density dependence of the symmetry energy from such collisions.Comment: 11 pages, 13 figures, submitted to Phys. Rev.

The Changing Composition of American-Citizen PhDs

We describe patterns in the composition of American-citizen doctorate recipients from the early 1960s to 2000. The propensity of bachelor’s degree recipients to earn PhDs varied widely during the 1960s and 1970s, especially for men, but has been relatively constant since the early 1980s. PhD propensity varies widely across students from different types of BA institutions, with higher propensities among those attending research universities and selective liberal-arts colleges. The share of PhDs awarded to women increased dramatically over the past 40 years and was driven largely by increases in the number of women earning BAs

The Complexity of the Spherical pp-spin spin glass model, revisited

Some questions concerning the calculation of the number of ``physical'' (metastable) states or complexity of the spherical $p$-spin spin glass model are reviewed and examined further. Particular attention is focused on the general calculation procedure which is discussed step-by-step.Comment: 13 pages, 3 figure

The Competitive Effects of Drug Withdrawals

In September 1997, the anti-obesity drugs Pondimin and Redux, ingredients in the popular drug combination fen-phen, were withdrawn from the market for causing potentially fatal side effects. That event provides an opportunity for studying how consumers respond to drug withdrawals. In theory, remaining drugs in the therapeutic class could enjoy competitive benefits, or suffer negative spillovers, from the withdrawal of a competing drug. Our findings suggest that, while the withdrawal of a rival drug may impose negative spillovers in the form of higher patient quit rates, on the whole non-withdrawn drugs in the same therapeutic class enjoy competitive benefits in the form of higher utilization.

The Other Side of the Trade Imbalance: What Will Japan Do?

With the mounting U.S. trade deficit, much attention has centered on the role of U.S. macroeconomic policy and economic structure as contributing factors. This paper contends that the economic structure and policies of Japan have also done much to contribute to the trade imbalance. Institutional features of Japan's macroeconomy and industrial structure which have promoted her large trade surplus are discussed and industrial policies evaluated. Given the nature and magnitude of the role played by Japan in causing the bilateral trade imbalance, the next question the paper addresses is how Japan might best act to alleviate this imbalance. This section of the paper examines fiscal, monetary and other policy initiatives Japan might take to reduce the trade imbalance. The evidence stresses the desirability of expanding Japan's services industries, particularly leisure-related services.

Generic Scrip Share and the Price of Brand-Name Drugs: The Role of the Consumer

Generic drug utilization has risen dramatically, from 19% of scrips in 1984 to 47% in 2001, thus bringing significant direct dollar savings. Generic drug use may also yield indirect savings if it lowers the average price of those brand-name drugs that are still purchased. Prior work indicates - and we confirm - that generic competition does not induce brand-name producers to lower prices. However, consumer choices between generic and brand-name drugs could affect the average price of those brand-name drugs that are purchased. We use nationally representative panel data on drug utilization and costs for the years 1996-2001 to examine how the share of an individual's prescriptions filled by generics affects his average out-of-pocket cost for brand-name drugs. Our principal finding is that a higher generic scrip share lowers average brand-name prices to consumers, presumably because consumers are more likely to substitute generics when the price gap is great. This effect is substantial: a 10% increase in the consumer's generic scrip share is associated with a 15.6% decline in the average price he pays for brand-name drugs.

Histopathology of the gut in rheumatic diseases

The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity to non-self-antigens. Various evidence indicates that intestinal inflammation occurs in patients with rheumatic diseases. In many rheumatic diseases intestinal inflammation appears to be linked to dysbiosis and possibly represents the common denominator in the pathogenesis of different rheumatic diseases. The continuative interaction between dysbiosis and the intestinal immune system may lead to the aberrant activation of immune cells that can re-circulate from the gut to the sites of extraintestinal inflammation as observed in patients with ankylosing spondylitis. The exact contribution of genetic factors in the development of intestinal inflammation in rheumatic diseases needs to be clarified