Using Exploratory Data Analytics to Identify Deficiencies in mCherry Red Fluorescent Protein and Suggest Improvements

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Glass transition and cooperative rearranging regions in amorphous thermoplastic nanocomposites

The aim of this work was to study the effect of nanofillers on the structural relaxation phenomena occurring in amorphous poly(ethylene-terephthalate)/poly(cyclohexane-dimethanol terephthalate) copolymer (PET/PCHDMT) nanocomposites in correspondence with the glass transition temperature. PET/PCHDMT nanocomposites were prepared by melt mixing with an organicmodified montmorillonite at different processing temperatures. Differential scanning calorimetry analysis revealed that addition of the organic modifier alone causes a decrease of the glass transition temperature and an increase of the specific heat discontinuity. Nanocomposites showed a higher glass transition temperature and a lower specific heat discontinuity compared with samples obtained by adding organic modifier to PET/PCHDMT. Both effects were more relevant for samples processed at lower temperatures. Therefore, the glass transition temperature was studied by introducing the concept of fictive temperature and relaxation time. It was found that nanocomposites have a higher apparent activation energy and an increased size of cooperatively rearranging regions compared with neat PET/PCHDMT. Both effects are more relevant for nanocomposites processed at lower temperatures. All the discussed effects are explained by considering the enhanced confinement of PET/PCHDMT macromolecules, due to the presence of intercalated lamellae of organofiller. The efficiency of intercalation is increased by decreased processing temperature, which involves an increase of the nano-confinement area of the polymer

ACTIVE FLOW CONTROL OF AN OVER-EXPANDED NOZZLE BY SHOCK VECTOR CONTROL

Thrust vectoring obtained by the nozzle flow manipulation technique known as Shock Vector Control (SVC) is investigated numerically. In the shock vector control method, a shock structure is generated in the main flow by using transversal continuous blowing. The pressure distribution on the nozzle walls becomes asymmetric, thus giving rise to a lateral force. The open-loop response of the nozzle and the thrust vectoring effectiveness/controllability are investigated by using a CFD tool based on the compressible URANS equations. Nozzle performances and thrust vector angles have been computed for different nozzle pressure ratios in the range of over-expanded conditions. The latter represent the worst case, where the shock structure generated by the control is amplified by the re-compression requirements imposed by the external ambient pressure

All you need is ratings: A clustering approach to synthetic rating datasets generation

The public availability of collections containing user preferences is of vital importance for performing offline evaluations in the field of recommender systems. However, the number of rating datasets is limited because of the costs required for their creation and the fear of violating the privacy of the users by sharing them. For this reason, numerous research attempts investigated the creation of synthetic collections of ratings using generative approaches. Nevertheless, these datasets are usually not reliable enough for conducting an evaluation campaign. In this paper, we propose a method for creating synthetic datasets with a configurable number of users that mimic the characteristics of already existing ones. We empirically validated the proposed approach by exploiting the synthetic datasets for evaluating different recommenders and by comparing the results with the ones obtained using real datasets

Managing patients taking novel oral anticoagulants (NOAs) in dentistry: A discussion paper on clinical implications

Background The aim of this paper is to contribute to the discussion on how to approach patients taking new orally administered anticoagulants (NOAs) dabigatran etexilate (a direct thrombin inhibitor), rivaroxaban and apixaban (factor Xa inhibitors), before, during and after dental treatment in light of the more recent knowledges. Discussion In dentistry and oral surgery, the major concerns in treatment of patients taking direct thrombin inhibitors and factor Xa inhibitors is the risk of haemorrhage and the absence of a specific reversal agent. The degree of renal function, the complexity of the surgical procedure and the patient\u2019s risk of bleeding due to other concomitant causes, are the most important factors to consider during surgical dental treatment of patients taking NOAs. For patients requiring simple dental extraction or minor oral surgery procedures, interruption of NOA is not generally necessary, while an higher control of bleeding and discontinuation of the drug (at least 24 h) should be requested before invasive surgical procedures, depending on renal functionality. Summary The clinician has to consider that the number of patients taking NOAs is rapidly increasing. Since available data are not sufficient to establish an evidence-based dental management, the dentist must use caution and attention when treating patients taking dabigatran, rivaroxaban and apixaban

robust die compensation in sheet metal design through the integration of dual response surface and shape function optimization

In sheet metal forming, springback represents a major drawback increasing die set-up problems, especially for ultra-high strength steels. Finite Element Analysis is a well-established method to simulate the process during design, and multicriteria optimizations, for example, via surrogate models, are investigated in order to develop integrated design. Since to take into account also springback compensation die design may involve a large number of geometric variables, this paper presents a robust design formulation, based on the adoption of the shape function optimization, to describe springback in terms of weights directly associated to global shape variations of the die shape. Doing so, multicriteria optimization, which involves also die compensation, can be set up in a more intuitive approach, as requested in the preliminary steps of die design. After the introduction of the industrial problem, the mathematical formulation of the shape function optimization is presented together with its novel extension to Robust Design, which is based on the Dual Response Surface. Through a test case derived from the head part of a B-pillar, stamped from a Dual Phase sheet 1.5 mm thick, this novel extension investigates the effect of 6% variation from nominal values of initial yield stress and thickness. Results demonstrate the feasibility of the procedure, underlying that an optimal compensation may not be optimal in terms of process robustness

Ultrasonic consolidation (UC) debulking of thermosetting prepreg for autoclave curing of composite laminates

Debulking of prepreg (pre-impregnated resin system) layers during hand lay-up manufacturing of carbon fibre reinforced polymers (CFRP) is a key-step to reduce air content and maximise the mechanical properties of the final product. Debulking is usually performed using vacuum-bag cycles of 10–15 min applied after the lay-up of every three or five prepreg layers, leading to a considerable time-consuming process. In this work, the use of ultrasonic stimulation during vacuum is studied to improve the efficiency of the debulking process and reduce the number of operations in order to decrease the overall manufacturing time. Three CFRP laminates were laid-up using the proposed ultrasonic consolidation (UC) with three different exposition times (5, 10 and 15 min) and cured in autoclave. The UC debulking process consists in a vacuum cycle with ultrasonic waves sent to the uncured material through an ultrasonic transducer. In order to evaluate the efficiency of this process interlaminar shear strength (ILSS) and in-plane compressive properties were tested. Experimental results show for 15 min compressive properties comparable with the ones obtained from reference samples manufactured using the traditional debulking technique, and high improvements in terms of ILSS (>20%). Therefore, UC debulking process can be used during hand lay-up of prepreg in order to improve the interlaminar properties of the final part and reduce the debulking time by over 85%