Prevalence, risk factors and genetic parameters of cresty neck in Pura Raza Español horses

Reasons for performing study: Cresty neck is a relatively common morphological defect in Pura Raza Español horses and other Baroque type horse breeds, which adversely affects the breeding industry. Objectives: To establish the within-breed prevalence, possible associated factors and heritability of cresty neck in Pura Raza Español horses. Study design: Cross-sectional analysis of a large worldwide database of Pura Raza Español horses. Methods: The database included evaluations of 10,929 Pura Raza Español horses from 24 countries. Cresty neck score, on a 9 point scale, girth-to-height ratio, height at the withers, length of neck, head–neck junction and neck–body junction were recorded. A Bayesian genetic animal model included the following systematic effects: girth-to-height ratio, age, sex, coat colour and geographical area of the stud. Animal and residual effects were included as random effects. Results: Within this Pura Raza Español population, 8.91% had a cresty neck score ≥5, which is the threshold for penalty or disqualification in the studbook of the breed. The age, sex, coat colour and stud geographical area were significantly associated with cresty neck score. The estimated heritability coefficient for cresty neck score was 0.37 (s.d. = 0.034) and genetic correlation between cresty neck score and other conformational traits ranged from −0.06 (height-at-withers) to −0.21 (neck–body junction). Conclusions: Cresty neck is a prevalent defect in Pura Raza Español horses, associated with age, sex, coat colour and other conformational traits, with a moderate level of heritability. Breeding to select against this condition may therefore be beneficial in this breed

Describing workload and scientific information on conditioning horses.

Abstract At the International Conference on Equine Exercise Physiology (ICEEP7), about 70 people attended the workshop on workload and conditioning guided by the authors. Most of the audience were involved in Thoroughbred or Standardbred racing, and only a limited number of people were mainly involved in FEI equestrian disciplines (sport horses). The workshop and this review article address the measurement of workload and conditioning of the Thoroughbred racehorse. It was proposed that workload could be quantified using a few selected parameters commonly recorded in the racing industries, such as velocity and distance, to generate a cumulative workload index. The review of conditioning focuses on the Thoroughbred racehorse and examines what can be modified with training, how training programmes should be designed based upon scientific methods and how training programmes should be routinely designed in current practice. It would appear that, in general, the methods used in practice for training Thoroughbred racehorses are quite similar to those used in a set of recent scientific studies, particularly in young (2?3-years-old) Thoroughbreds. Nevertheless, both the length of the training programme and the total amount of exercise are usually shorter/lower than ideal in order to maximize physiological adaptations within the animal's body. In planning the training programme, it is very important to recognize that different adaptations occur at different rates, and this will affect the relative amount of training that should be applied to achieve specific adaptations

Análise de imagem para determinação do teor de saponina em quinoa Image analysis to determinate the saponin content in quinoa

Um grupo de sementes lavadas e 35 acessos de quinoa (Chenopodium quinoa Willd) foram avaliados pelo método de coluna de espuma e sua coloração foi decomposta pelo modelo RGB (R, vermelho; G, verde; B, azul) com o objetivo de avaliar a influência do teor de saponina na cor do grão. Sementes amarelas apresentaram alto teor de saponina. Houve correlação negativa (p£0,05) entre o teste de coluna de espuma e as bandas R (r = -0,751), G (r = -0,660) e B (r = -0,594). Estabeleceram-se quatro grupos de similaridade. Foram considerados amargos os acessos do grupo 4 (sementes amarelas) e doces os acessos do grupo 1 (sementes brancas). A dispersão observada representa provável diferença na freqüência gênica, refletida pela cor e teor de saponina.<br>A group of washed seeds and thirty five genotypes of quinoa (Chenopodium quinoa, Willd) were screened by soap column method and were classified by RGB Color Model (R, red; G, green; B, blue) with the objective to determine the influence of the saponin content in the grain color. Yellow seeds presented high levels of saponin. There was negative correlation (p£0.05) among soap column method and bands R (r = -0.751), G (r = -0.660) and B (r = -0.594). Four groups were fixed. Tests confirmed the access of group 4 as bitter (yellow seeds) and the access of group 1 as sweet (white seeds). The dispersion represents probable difference in gene frequency, reflected by the color and rate of saponin

Gender-Related Differences in Presentation, Treatment, and Outcome of Patients With Atrial Fibrillation in Europe. A Report From the Euro Heart Survey on Atrial Fibrillation

Objectives: This study sought to investigate gender-related differences in patients with atrial fibrillation (AF) in Europe. Background: Gender-related differences may play a significant role in AF. Methods: We analyzed the data of 5,333 patients (42% female) enrolled in the Euro Heart Survey on Atrial Fibrillation. Results: Compared with men, the women were older, had a lower quality of life (QoL), had more comorbidities, more often had heart failure (HF) with preserved left ventricular systolic function (18% vs. 7%, p &lt; 0.001), and less often had HF with systolic dysfunction (17% vs. 26%, p &lt; 0.001). Among patients with typical AF symptoms (56% of women, 49% of men), there was no gender-related difference in the choice of rate or rhythm control. Among patients with atypical or no symptoms (44% of women, 51% of men), women less frequently underwent rhythm control (39% vs. 51%, p &lt; 0.001) than did men. Women underwent less electrical cardioversion (22% vs. 28%, p &lt; 0.001). Prescription of oral anticoagulants was identical (65%) in both genders. One-year outcome was similar except that women had a higher chance for stroke (odds ratio 1.83 in multivariable regression analysis, p = 0.019). Conclusions: Women with AF had more comorbidities, more HF with preserved systolic function, and a lower QoL than men. In the large group with atypical or no symptoms, women were treated appropriately more conservatively with less rhythm control than men. Women had a higher chance for stroke. Long-term QoL changes and other morbidities and mortality were similar. © 2007 American College of Cardiology Foundation

Antithrombotic treatment in real-life atrial fibrillation patients: a report from the Euro Heart Survey on Atrial Fibrillation

Aims To describe guideline adherence and application of different stroke risk strati. cation schemes regarding antithrombotic therapy in real-life atrial. brillation (AF) patients and to assess which factors influence antithrombotic management decisions.Methods and results The Euro Heart Survey enrolled 5333 AF patients in 35 countries, in 2003 and 2004. Prescription of antithrombotic drugs, especially oral anticoagulation (OAC), was hardly tailored to the patient's stroke risk pro. le as indicated by the joint guidelines of the American College of Cardiology, American Heart Association, and the European Society of Cardiology, ACCP guidelines, or CHADS(2) and Framingham risk scores. In multivariable analysis, only a limited number of the well-known stroke risk factors triggered OAC prescription. In contrast, less relevant factors, of which clinical type of AF and availability of an OAC monitoring outpatient clinic were the most marked, played a significant role in OAC prescription. Electrical cardioversions and catheter ablations clearly triggered OAC prescription, whereas pharmacological cardioversions even in the presence of stroke risk factors did not.Conclusion Antithrombotic therapy in AF is hardly tailored to the patient's stroke risk pro. le. Factors other than well-known stroke risk factors were significantly involved in antithrombotic management decisions. To facilitate this tailored treatment, guideline writers and physician educators should focus on providing one uniform and easy to use stroke risk strati. cation scheme