Markers of infection, breast-feeding and childhood acute lymphoblastic leukaemia

Infections are suspected to play a role in the aetiology of childhood leukaemia. In 1989–95, we evaluated the relation between childhood acute lymphoblastic leukaemia and pre- and postnatal markers of exposure to infection, as well as breast-feeding. A population-based case-control study was carried out in certain regions of Québec, Canada, in 1989–95 including 491 incident cases diagnosed between 1980 and 1993 and aged between 0 and 9 years. An identical number of healthy controls matched for age, sex and region of residence at the date of diagnosis was included. Having older siblings, mother's use of antibiotics during pregnancy, and being born second or later were all associated with increased risk of leukaemia while early day-care attendance (odds ratio (OR) = 0.49; 95% CI 0.31–0.77), and breast-feeding (OR = 0.68; 95% CI 0.49–0.95) were significantly protective. A marker of population mixing was not a risk factor. When including all variables defining family structure in a model, having older siblings at time of diagnosis was a risk factor among children diagnosed before 4 years of age (OR = 4.54; 95% CI 2.27–9.07) whereas having older siblings in the first year of life was protective among children diagnosed at 4 years of age or later (OR = 0.46; 95% CI 0.22–0.97). © 2000 Cancer Research Campaign http://www.bjcancer.co

Stimulation of tPA-dependent provisional extracellular fibrin matrix degradation by human recombinant soluble melanotransferrin

AbstractTissue-type plasminogen activator (tPA) and its substrate plasminogen (Plg) are key components in the fibrinolytic system. We have recently demonstrated, that truncated human recombinant soluble melanotransferrin (sMTf) could stimulate the activation of Plg by urokinase plasminogen activator and inhibit angiogenesis. Since various angiogenesis inhibitors were shown to stimulate tPA-mediated plasminogen activation, we examined the effects of sMTf on tPA-dependent fibrinolysis. This study demonstrated that sMTf enhanced tPA-activation of Plg by 6-fold. sMTf also increased the release of [125I]-fibrin fragments by tPA-activated plasmin. Moreover, we observed that the interaction of sMTf with Plg provoked a change in the fibrin clot structure by cleaving the fibrin α and β chains. Overall, the present study shows that sMTf modulates tPA-dependent fibrinolysis by modifying the clot structure. These results also suggest that sMTf properties could involve enhanced dissolution of the provisional extracellular fibrin matrix

Patterns in Longline Reef Fish Catch and Fishing Gear Analysis in the Gulf of Mexico Using NOAA Fishery Observer Data

The objectives of this study were to assess existing fishing practices (both spatial and gear use) employed by longline reef fish fishers in the Gulf of Mexico; to evaluate the gear and set parameters that contribute to catching larger individual fish of a target species; and to assess the gear and set parameters that contribute to successfully catching a fish of a target species. Data were collected by the Southeast Fisheries Science Center (SEFSC) Galveston Reef Fish Observer Program from 2006-2014. Explanatory variables included in the study were only those that could be manipulated directly by fishers: soak time, fishing depth, main line length, hooks deployed, gangion length, hook distance, and the temporal variables month and year. Gear change assessments were conducted using analyses of variance for soak time, fishing depth, gangion length, hook distance, mainline length, and hook count across years. Significant differences were detected between years for all variables, however, there was no discernable trend over time. This suggests that fishing practices remained relatively stable from 2006-2014. Spatial analysis of catches was conducted for five species targeted during the study period (gag grouper, red grouper, scamp grouper, mutton snapper, and red snapper) using ArcGIS. However, no spatial trends were apparent given the uneven effort and coverage of the survey area. To assess which fishing gear and set parameters contributed to catching the largest fish of a target species, ordinary least squares (OLS) linear models were used to predict iii fish length as a function of the explanatory variables. Significant models were generated for blacknose shark, gag grouper, mutton snapper, red porgy, Atlantic sharpnose shark, and speckled hind. Binomial regression models were constructed using backwards regression to predict target species catch success using the explanatory variables. Significant models were generated for speckled hind, red grouper, scamp, gag grouper, red snapper, mutton snapper, jolthead porgy, and red porgy. These models ultimately serve as guidelines for fishers to adjust fishing practices to improve the likelihood of successfully obtaining the targeted species, which may reduce bycatch mortality of non-target species and its resulting environmental impacts

International workshop on immune tolerance induction: consensus recommendations 1

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73382/1/j.1365-2516.2007.01497.x.pd

The interaction of lean and building information modeling in construction

Lean construction and Building Information Modeling are quite different initiatives, but both are having profound impacts on the construction industry. A rigorous analysis of the myriad specific interactions between them indicates that a synergy exists which, if properly understood in theoretical terms, can be exploited to improve construction processes beyond the degree to which it might be improved by application of either of these paradigms independently. Using a matrix that juxtaposes BIM functionalities with prescriptive lean construction principles, fifty-six interactions have been identified, all but four of which represent constructive interaction. Although evidence for the majority of these has been found, the matrix is not considered complete, but rather a framework for research to explore the degree of validity of the interactions. Construction executives, managers, designers and developers of IT systems for construction can also benefit from the framework as an aid to recognizing the potential synergies when planning their lean and BIM adoption strategies

The enhanced cognitive interview: expressions of uncertainty, motivation and its relation with report accuracy

The Enhanced Cognitive Interview (ECI) is one of the most widely studied and used methods to interview witnesses. However, ECI research has mainly focused on increasing report size and somewhat overlooked how to improve and evaluate report accuracy. No study evaluated if witnesses’ spontaneous expressions of uncertainty are accurate metacognitive judgments, nor if witnesses’ motivation during the interview affects report accuracy. This study examined how witnesses’ judgments of recall ‘uncertainty’ and their motivation perception could relate to report accuracy. Forty-four psychology students watched a mock robbery video recording and were interviewed 48 hours later with either the Portuguese version of the ECI or a Structured Interview (SI). Afterward, participants’ motivation was assessed and items of information were classified as ‘certainties’ or ‘uncertainties’. Results suggest that our ECI protocol was effective, since participants interviewed with the ECI produced more information without compromising accuracy. ‘Uncertainties’ were less accurate than ‘certainties’, and their exclusion raised overall, ECI, and SI, accuracy. More motivated participants had better recall accuracy. Accounting for witnesses’ motivation and spontaneous verbal expressions of uncertainty may be effective and time-saving procedures to increase accuracy. These are key points that professionals and researchers should consider