Fibronectin in human gallbladder bile: cholesterol pronucleating and/or mucin "link" protein?

Some biliary proteins (pronucleators) seem to be essential factors for cholesterol crystal formation and crystal growth in bile. A recent study suggests that fibronectin is such a pronucleator in bile. Fibronectin also seems to closely interact with intestinal mucin. Since biliary mucin plays an important role in gallstone formation, such an interaction in bile may be of relevance in cholesterol gallstone formation. To more clearly elucidate the role of fibronectin in cholesterol gallstone disease, we measured the concentration of fibronectin in native bile of cholesterol gallstone patients and checked its influence on the cholesterol nucleation time of model bile. We further looked for a molecular interaction between biliary fibronectin and gallbladder mucin. We found that fibronectin is present in gallbladder bile of gallstone patients in low concentrations (2.6 +/- 1.2 micrograms/ml). Bile fibronectin did not interact with gallbladder mucin. Moreover, in a wide range of concentrations fibronectin had no influence on the nucleation time of model bile. We conclude that fibronectin does not seem to play a major role in cholesterol gallstone disease

Neogene fluvial landscape evolution in the hyperarid core of the Atacama Desert

Dating of extensive alluvial fan surfaces and fluvial features in the hyperarid core of the Atacama Desert, Chile, using cosmogenic nuclides provides unrivalled insights about the onset and variability of aridity. The predominantly hyperarid conditions help to preserve the traces of episodic climatic and/or slow tectonic change. Utilizing single clast exposure dating with cosmogenic 10Be and 21Ne, we determine the termination of episodes of enhanced fluvial erosion and deposition occurring at ~19, ~14, ~9.5 Ma; large scale fluvial modification of the landscape had ceased by ~2–3 Ma. The presence of clasts that record pre-Miocene exposure ages (~28 Ma and ~34 Ma) require stagnant landscape development during the Oligocene. Our data implies an early onset of (hyper-) aridity in the core region of the Atacama Desert, interrupted by wetter but probably still arid periods. The apparent conflict with interpretation that favour a later onset of (hyper-) aridity can be reconciled when the climatic gradients within the Atacama Desert are considered

Evidence for multiple Plio-Pleistocene lake episodes in the hyperarid Atacama Desert

Cosmogenic nuclide exposure dating of ancient shoreline terraces of the Quillagua-Llamara Soledad Lake in the central Atacama Desert of northern Chile provides new insights in the paleohydrology of the driest desert on Earth. The lake developed in a paleo-endorheic drainage system in the Central Depression prior to draining into the Pacific due to incision of the Río Loa canyon. The durations of lake stages were sufficiently long to form wave-erosion induced shoreline terraces on the wind-exposed slopes of former islands. Successively younger shoreline levels are preserved over an elevation range of 250 m due to progressive uplift of the islands coeval with the lake stages. Cosmogenic 10Be- and 21Ne-derived exposure ages of the shorelines reveals that the hyperarid conditions in the Río Loa catchment were interspersed by several pluvial stages during the Pliocene and Pleistocene, which generated a large and persistent lake in the Quillagua-Llamara basin. The exposure ages of the final lake stage provide the maximum age for the incision of the Río Loa canyon (274 ± 74 ka) and the subsequent breaching of the Coastal Cordillera

Methodology for cost-effective energy and carbon emissions optimization in building renovation (Annex 56): methodology and assessment of renovation measures by parametric calculations

Buildings are responsible for a major share of energy use and have accordingly been a special target in the global actions for climate change mitigation, with measures that aim at improving their energy efficiency, reduce carbon emissions and increase renewable energy use. IEA-EBC project «Cost-Effective Energy and Carbon Emissions Optimization in Building Renovation» intends to develop a calculation basis for future standards, which aim at maximum effects on reducing carbon emissions and primary energy use. Thereby, the project pays special attention to the renovation of existing residential buildings and to cost effective building renovatio

Methodology for cost-effective energy and carbon emissions optimization in building renovation (Annex 56)

"Energy in Buildings and Communities Programme, March 2017"Buildings are responsible for a major share of energy use and have been a special target in the global actions for climate change mitigation, with measures that aim at improving their energy efficiency, reduce carbon emissions and increase renewable energy use. The IEA-EBC Annex 56 project «Cost-Effective Energy and Carbon Emissions Optimization in Building Renovation» intends to develop the basics for future standards, which aim at maximizing effects on reducing carbon emissions and primary energy use while taking into account the cost-effectiveness of related measures. The IEA EBC Annex 56 project pays special attention to cost effective energy related renovation of existing residential buildings and low-tech office buildings (without air conditioning systems).info:eu-repo/semantics/publishedVersio