Assessing the Market for Poultry Litter in Georgia: Are Subsidies Needed to Protect Water Quality?

Concerns about nutrient loads into our waters have focused attention on poultry litter applications. Like many states with a large poultry industry, Georgia recently designed a subsidy program to facilitate the transportation of poultry litter out of vulnerable watersheds. This paper uses a transportation model to examine the necessity of a poultry litter subsidy to achieve water protection goals in Georgia. We also demonstrate the relationship between diesel and synthetic fertilizer prices and the value of poultry litter. Results suggest that a well functioning market would be able to remove excess litter from vulnerable watersheds in the absence of a subsidy.fertilizer, phosphorous, poultry litter, subsidy, transportation model, water quality, Environmental Economics and Policy, Marketing, Q12, Q13, Q25, Q53,

Common business cycles and volatilities in US states and MSAs: The role of economic uncertainty

This paper analyses the role of a news-based measure of economic policy uncertainty (EPU) in explaining time-varying co-movements in economic activity and volatility of 48 US states and 51 largest MSAs. In this regard, we, first, estimate a dynamic factor model with time-varying loadings and stochastic volatility (DFM-TV-SV). Then, in the second step, we use a quantile-on-quantile (QQ) predictive regression model to capture the effect of EPU on the common factor and stochastic volatility derived from the DFM-TV-SV for the states and MSAs. Our results show that EPU has a significant negative effect on the common economic activity of both the states and MASs, and it also significantly increases the common volatility. However, the impact of uncertainty varies substantially depending on the initial states (quantiles) of both common output or volatility and EPU. Thus, our results tend to suggest that policy design should be state-dependent

A single chromosome assembly of Bacteroides fragilis strain BE1 from Illumina and MinION nanopore sequencing data

BACKGROUND: Second and third generation sequencing technologies have revolutionised bacterial genomics. Short-read Illumina reads result in cheap but fragmented assemblies, whereas longer reads are more expensive but result in more complete genomes. The Oxford Nanopore MinION device is a revolutionary mobile sequencer that can produce thousands of long, single molecule reads. RESULTS: We sequenced Bacteroides fragilis strain BE1 using both the Illumina MiSeq and Oxford Nanopore MinION platforms. We were able to assemble a single chromosome of 5.18 Mb, with no gaps, using publicly available software and commodity computing hardware. We identified gene rearrangements and the state of invertible promoters in the strain. CONCLUSIONS: The single chromosome assembly of Bacteroides fragilis strain BE1 was achieved using only modest amounts of data, publicly available software and commodity computing hardware. This combination of technologies offers the possibility of ultra-cheap, high quality, finished bacterial genomes

The role of term spread and pattern changes in predicting stock returns and volatility of the United Kingdom: Evidence from a nonparametric causality-in-quantiles test using over 250 years of data

Given the existence of nonlinear relationship between equity premium and term spread, as well as pattern changes and the interaction of pattern changes with the term-spread and changes in the shape of the yield curve, we use a nonparametric k-th order causality-in-quantiles test to predict the movement in excess returns and volatility based on changes in the shape of the yield curve. With the test applied to over 250 years of monthly data for the UK covering the period 1753:08 to 2017:02, we find that pattern changes and the interaction of pattern changes with the term-spread, besides the term spread itself, tends to also play an important role in predicting volatility at the upper end of its conditional distribution. In addition, the effect on excess returns from term spread, pattern changes and the interaction is found to have improved markedly over time, barring at the conditional median of the equity premium. Finally, comparisons are made with historical data of the US and South Africa, and implications of our results are discussed

Modeling Phosphorus Loading to Lake Allatoona: Implications for Water Quality Trading

Proceedings of the 2007 Georgia Water Resources Conference, March 27-29, 2007, Athens, Georgia.Lake Allatoona, a large reservoir north of Atlanta Georgia that drains an area of about 2870 km2, is threatened by excessive algal growth and scheduled for a phosphorus (P) TMDL. In this paper, we use the Soil Water Assessment Tool (SWAT) computer model to estimate the total P load to Lake Allatoona during the periods 1992-1996 and 2001-2004. We also use the model to estimate the contribution from different sources in the watershed. The total P load to Lake Allatoona increased by 20% between the two time periods. The contribution from point sources decreased from 30% to 13% of the total load due to permit restrictions on P for poultry processing plants. The largest nonpoint source of P was estimated to be forest land use in 1992-1996 accounting for 31% of the load and urban land use in 2001-2004 accounting for 50% of the load. Poultry/cattle land use accounted for 18% in 1992-1996 and 15% in 2001-2004. The implications for a program to trade P credits are: 1) point sources and poultry/cattle operations account for similar percentages of the current load, 2) urban development accounts for most of the current P load and should be brought into a trading program, 3) poultry processing plants that have not upgraded to better P removal technology might trade their current load to wastewater treatment facilities that accept their wastewater, 4) cattle in streams and row crops are not large sources according to our model, and 5) there is little net loss of P to streams during transport to Lake Allatoona so distance of a source from the lake may not be important in a trading scheme.Sponsored and Organized by: U.S. Geological Survey, Georgia Department of Natural Resources, Natural Resources Conservation Service, The University of Georgia, Georgia State University, Georgia Institute of TechnologyThis book was published by the Institute of Ecology, The University of Georgia, Athens, Georgia 30602-2202. The views and statements advanced in this publication are solely those of the authors and do not represent official views or policies of The University of Georgia, the U.S. Geological Survey, the Georgia Water Research Institute as authorized by the Water Resources Research Act of 1990 (P.L. 101-397) or the other conference sponsors

Georgia's water conservation efforts: Cooperative Extension's banner effort

Proceedings of the 2009 Georgia Water Resources Conference, April 27, 28, and 29, 2009 Athens, Georgia.Georgia has been gripped by drought for much of 2007 and 2008. UGA Cooperative Extension selected water conservation as a statewide priority in 2007 and developed educational materials for programming through county extension efforts. The project included components dealing with outdoor water use in conjunction with the Georgia DNR's WaterSmart program, with indoor water use in conjunction with the College of Family and Consumer Sciences, and a youth component in conjunction with the Georgia 4-H program. This presentation will include an overview of the materials developed as well as a discussion of some of the outputs and evaluations that have been conducted.Sponsored by: Georgia Environmental Protection Division U.S. Geological Survey, Georgia Water Science Center U.S. Department of Agriculture, Natural Resources Conservation Service Georgia Institute of Technology, Georgia Water Resources Institute The University of Georgia, Water Resources FacultyThis book was published by Warnell School of Forestry and Natural Resources, The University of Georgia, Athens, Georgia 30602-2152. The views and statements advanced in this publication are solely those of the authors and do not represent official views or policies of The University of Georgia, the U.S. Geological Survey, the Georgia Water Research Institute as authorized by the Water Research Institutes Authorization Act of 1990 (P.L. 101-307) or the other conference sponsors

Loss of residues 119 – 136, including the first β-strand of human prion protein, generates an aggregation-competent partially “open” form

In prion replication, the cellular form of prion protein (PrPC) must undergo a full conformational transition to its disease-associated fibrillar form. Transmembrane forms of PrP have been implicated in this structural conversion. The cooperative unfolding of a structural core in PrPC presents a substantial energy barrier to prion formation, with membrane insertion and detachment of parts of PrP presenting a plausible route to its reduction. Here, we examined the removal of residues 119 - 136 of PrP, a region which includes the first β-strand and a substantial portion of the conserved hydrophobic region of PrP, a region which associates with the ER membrane, on the structure, stability and self-association of the folded domain of PrPC. We see an "open" native-like conformer with increased solvent exposure which fibrilises more readily than the native state. These data suggest a stepwise folding transition, which is initiated by the conformational switch to this "open" form of PrPC

Building Capacity within Extension to Address Animal Agriculture in a Changing Climate

The Animal Agriculture in a Changing Climate project was formed to build capacity among Extension professionals and other livestock advisors to address climate change issues. We offer a case study of how a small team can build national capacity for new topics. We used a coordinated multiregional approach to leverage national efforts applied to locally relevant climatology, production systems, and climate issues. Key insights on overcoming challenges centered on (a) engaging audiences with local, historical trends and agricultural impacts, (b) beginning with adaptation, rather than mitigation of climate change, and (c) providing strategies for effectively communicating science during controversy. Program participants found the project valuable and substantially increased their ability and motivation to apply climate science

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity

Growing evidence suggests water-soluble, non-fibrillar forms of amyloid-β protein (Aβ) have important roles in Alzheimer’s disease with toxicities mimicked by synthetic Aβ1–42. However, no defined toxic structures acting via specific receptors have been identified and roles of proposed receptors, such as prion protein (PrP), remain controversial. Here we quantify binding to PrP of Aβ1–42 after different durations of aggregation. We show PrP-binding and PrP-dependent inhibition of long-term potentiation (LTP) correlate with the presence of protofibrils. Globular oligomers bind less avidly to PrP and do not inhibit LTP, whereas fibrils inhibit LTP in a PrP-independent manner. That only certain transient Aβ assemblies cause PrP-dependent toxicity explains conflicting reports regarding the involvement of PrP in Aβ-induced impairments. We show that these protofibrils contain a defined nanotubular structure with a previously unidentified triple helical conformation. Blocking the formation of Aβ nanotubes or their interaction with PrP might have a role in treatment of Alzheimer’s disease

Quantification of pulmonary perfusion abnormalities using DCE-MRI in COPD: comparison with quantitative CT and pulmonary function

Objectives Pulmonary perfusion abnormalities are prevalent in patients with chronic obstructive pulmonary disease (COPD), are potentially reversible, and may be associated with emphysema development. Therefore, we aimed to evaluate the clinical meaningfulness of perfusion defects in percent (QDP) using DCE-MRI. Methods We investigated a subset of baseline DCE-MRIs, paired inspiratory/expiratory CTs, and pulmonary function testing (PFT) of 83 subjects (age = 65.7 +/- 9.0 years, patients-at-risk, and all GOLD groups) from one center of the COSYCONET COPD cohort. QDP was computed from DCE-MRI using an in-house developed quantification pipeline, including four different approaches: Otsu's method, k-means clustering, texture analysis, and 80(th) percentile threshold. QDP was compared with visual MRI perfusion scoring, CT parametric response mapping (PRM) indices of emphysema (PRMEmph) and functional small airway disease (PRMfSAD), and FEV1/FVC from PFT. Results All QDP approaches showed high correlations with the MRI perfusion score (r = 0.67 to 0.72, p < 0.001), with the highest association based on Otsu's method (r = 0.72, p < 0.001). QDP correlated significantly with all PRM indices (p < 0.001), with the strongest correlations with PRMEmph (r = 0.70 to 0.75, p < 0.001). QDP was distinctly higher than PRMEmph (mean difference = 35.85 to 40.40) and PRMfSAD (mean difference = 15.12 to 19.68), but in close agreement when combining both PRM indices (mean difference = 1.47 to 6.03) for all QDP approaches. QDP correlated moderately with FEV1/FVC (r = - 0.54 to - 0.41, p < 0.001). Conclusion QDP is associated with established markers of disease severity and the extent corresponds to the CT-derived combined extent of PRMEmph and PRMfSAD. We propose to use QDP based on Otsu's method for future clinical studies in COPD