659 research outputs found
Magnetization driven metal - insulator transition in strongly disordered Ge:Mn magnetic semiconductors
We report on the temperature and field driven metal-insulator transition in
disordered Ge:Mn magnetic semiconductors accompanied by magnetic ordering,
magnetoresistance reaching thousands of percents and suppression of the
extraordinary Hall effect by a magnetic field. Magnetoresistance isotherms are
shown to obey a universal scaling law with a single scaling parameter depending
on temperature and fabrication. We argue that the strong magnetic disorder
leads to localization of charge carriers and is the origin of the unusual
properties of Ge:Mn alloys.Comment: 10 pages, 5 figure
A novel fluorescence in situ hybridization test for rapid pathogen identification in positive blood cultures
AbstractA novel molecular beacon-based fluorescence in situ hybridization (FISH) test allowing for the identification of a wide range of bacterial pathogens directly in positive blood cultures (BCs) was evaluated with positive BCs of 152 patients. Depending on the Gram stain, either a Gram-negative or a Gram-positive panel was used. The time to result was 30 min, and the hands-on time was only 10 min. Seven per cent of the cultured microorganisms were not included in the FISH panels; the identification rate of those included was 95.2%. Overall, the FISH test enabled accurate pathogen identification in 88.2% of all cases analysed
In Vitro Viability and Cytotoxicity Testing and Same-Well Multi-Parametric Combinations for High Throughput Screening
In vitro cytotoxicity testing has become an integral aspect of drug discovery because it is a convenient, costeffective, and predictive means of characterizing the toxic potential of new chemical entities. The early and routine implementation of this testing is testament to its prognostic importance for humans. Although a plethora of assay chemistries and methods exist for 96-well formats, few are practical and sufficiently sensitive enough for application in high throughput screening (HTS). Here we briefly describe a handful of the currently most robust and validated HTS assays for accurate and efficient assessment of cytotoxic risk. We also provide guidance for successful HTS implementation and discuss unique merits and detractions inherent in each method. Lastly, we discuss the advantages of combining specific HTS compatible assays into multi-parametric, same-well formats
Faculty Recital: Jean Clay Radice, harpsichord; Mark A. Radice, harpsichord; Mary Holzhauer, harpsichord; Jonathan Riss, harpsichord; Nicholas Kelliher, countertenor
Delta-Function Potential with a Complex Coupling
We explore the Hamiltonian operator H=-d^2/dx^2 + z \delta(x) where x is
real, \delta(x) is the Dirac delta function, and z is an arbitrary complex
coupling constant. For a purely imaginary z, H has a (real) spectral
singularity at E=-z^2/4. For \Re(z)<0, H has an eigenvalue at E=-z^2/4. For the
case that \Re(z)>0, H has a real, positive, continuous spectrum that is free
from spectral singularities. For this latter case, we construct an associated
biorthonormal system and use it to perform a perturbative calculation of a
positive-definite inner product that renders H self-adjoint. This allows us to
address the intriguing question of the nonlocal aspects of the equivalent
Hermitian Hamiltonian for the system. In particular, we compute the energy
expectation values for various Gaussian wave packets to show that the
non-Hermiticity effect diminishes rapidly outside an effective interaction
region.Comment: Published version, 14 pages, 2 figure
Spherical-box approach for resonances in presence of Coulomb interaction
The spherical-box approach is extended to calculate the resonance parameters
and the real part of the wave function for single particle resonances in a
potential containing the long-range Coulomb interaction. A model potential is
taken to demonstrate the ability and accuracy of this approach. The calculated
resonance parameters are compared with available results from other methods. It
is shown that in the presence of the Coulomb interaction, the spherical-box
approach works well for not so broad resonances. In particular, for very narrow
resonances, the present method gives resonance parameters in a very high
precision.Comment: 10 pages, 5 EPS figures; to be published in J. Phys.
Pseudo-time Schroedinger equation with absorbing potential for quantum scattering calculations
The Schroedinger equation with an energy-dependent complex absorbing
potential, associated with a scattering system, can be reduced for a special
choice of the energy-dependence to a harmonic inversion problem of a discrete
pseudo-time correlation function. An efficient formula for Green's function
matrix elements is also derived. Since the exact propagation up to time 2t can
be done with only t real matrix-vector products, this gives an unprecedently
efficient scheme for accurate calculations of quantum spectra for possibly very
large systems.Comment: 9 page
Conceptual Foundations for a Service-oriented Knowledge and Learning Architecture: Supporting Content, Process and Ontology Maturing
Abstract: The knowledge maturing model views learning activities as embedded into, interwoven with, and even indistinguishable from everyday work processes. Learning is understood as an inherently social and collaborative activity. The Knowledge Maturing Process Model structures this process into five phases: expressing ideas, distributing in communities, formalizing, ad-hoc learning and standardization. It is applicable not only for content but also to process knowledge and semantics. In the MATURE IP two toolsets will be develop that support the maturing process: a personal learning environment and an organisation learning environment integrating the levels of individuals, communities and organisation. The development is guided by the SER theory of seeding, evolutionary growth and reseeding and is based on generally applicable maturing services
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