Eighth Major Clade for Hepatitis Delta Virus

Hepatitis delta virus is the only representative of the Deltavirus genus, which consists of 7 differentiated major clades. In this study, an eighth clade was identified from 3 distinct strains. Deltavirus genetic variability should be considered for diagnostic purposes. Clinical consequences of the diversity have yet to be evaluated

Impact of ribavirin dose on retreatment of chronic hepatitis C patients

AIM: To study the efficacy and factors associated with a sustained virological response (SVR) in chronic hepatitis C (CHC) relapsing patients

Early serum HBsAg drop: a strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg negative patients. Hepatology

Pegylated interferon alfa-2a (PEG-IFN) may induce sustained virological response (SVR) in infection with a high efficacy in suppressing HBV replication. However, a long duration of treatment is needed to maintain viral suppression, and the major question of whether oral therapy can ever be stopped remains unanswered

In vitro infection of primary human hepatocytes by HCV-positive sera: insights on a highly relevant model

International audienceAdult primary human hepatocytes (PHHs) support the complete infection cycle of natural HCV from patients' sera. The molecular details underlying sera infectivity towards these cells remain largely unknown. Therefore, we sought to gain a deeper comprehension of these features in the most physiologically relevant culture system