7 research outputs found
Attune, animate and amplify: Creating youth voice assemblages in pARTicipatory sexuality education research
This paper explores the politics and praxis of âyouth voice assemblagesâ in an exploratory and pARTicipatory research project where 125 young people (aged 11â18) from England, Scotland and Wales shared what and how they are learning about relationships, sex and sexuality. Creative methods enabled us to âattuneâ to this learning and generate âdartaâ (artsâbased data). We then âanimatedâ these darta as dartaphacts (creative objects) including films, poetry and education cards. Finally, we âamplifiedâ these dartaphacts in a faceâtoâface launch event. We argue that a creative ontology of âyouth voiceâ is imperative to develop more relevant, responsive and ethical sexuality and relationships education
Contribution of the SuUR gene to the organization of epigenetically repressed regions of Drosophila melanogaster chromosomes
A significant portion of a eukaryotic genome is silent (epigenetically repressed). In Drosophila melanogaster, this portion includes mainly regions of pericentric and intercalary heterochromatin and euchromatin regions subject to position-effect variegation. Detailed study of the organization of intercalary heterochromatin regions of Drosophila melanogaster polytene chromosomes started from the discovery of the SuUR gene (Suppressor of UnderReplication). The ability of the SuUR mutation to suppress underreplication in intercalary heterochromatin regions was used for molecular tagging of these regions. We showed that underreplicated intercalary heterochromatin regions contained silent unique genes and retained the features of late replication and transcriptionally inactive chromatin state in various cell types. Over 50% of these regions contain unique genes clustered on the base of coordinated expression. The origin of clusters and putative mechanisms of their gene expression are discussed. Data on the SuUR gene, its expression, and effect on polytene chromosome structure and replication are summarized