Development of Mobile Machining Cell

This report covers some initial aspects of development of the mobile InnoMill machining cell. The new machining paradigm where the machine is mounted on the workpiece is compared to the old paradigm where the workpiece is mounted inside the machine, and differences are discussed. Parametric studies of the workpiece case study of the InnoMill project, the Vestas V112-3.0MW wind turbine hub, are performed to supply insight regarding load capacity etc. for the machine designers. The hub finite element model is validated using experimental results from Operational Modal Analysis performed on the hub. Furthermore, the InnoMill concept is described, and work regarding the 6 degree of freedom parallel kinematic manipulator which is present in the concept is performed. A numerical procedure accounting for base deflections due to static loading is proposed and implemented. Additionally, a six degree of freedom spring-mass model vibrational response is compared to vibrational response obtained from experiments on the 6 degree of freedom parallel kinematic manipulator at Aarhus University. The model, which is based on assumptions commonly found in literature, is rejected. Finally, an outlook for the remaining part of the PhD project is presented

No neuroprotective effect of therapeutic hypothermia following lipopolysaccharide-sensitized hypoxia-ischemia: a newborn piglet study

IntroductionTherapeutic hypothermia is the only proven neuroprotective treatment for hypoxic-ischemic encephalopathy. However, studies have questioned whether therapeutic hypothermia may benefit newborns subjected to infection or inflammation before a hypoxic-ischemic insult. We aimed to compare newborn piglets with lipopolysaccharide-sensitized hypoxia-ischemia treated with and without therapeutic hypothermia with regards to measures of neuroprotection.MethodsA total of 32 male and female piglets were included in this randomized experimental study. Lipopolysaccharides from Escherichia coli were infused intravenously before initiation of a standardized global hypoxic-ischemic insult. The piglets were then randomized to either normothermia or therapeutic hypothermia. After 14 h, the piglets were evaluated. Our primary outcome was brain lactate/N-acetylaspartate ratio assessed by magnetic resonance spectroscopy. Secondary outcomes included measures of magnetic resonance imaging, amplitude-integrated electroencephalography, immunohistochemistry, and concentration of blood cells and cytokines.ResultsPiglets treated with and without therapeutic hypothermia were subjected to comparable global hypoxic-ischemic insults. We found no difference between the two groups with regards to measures of magnetic resonance spectroscopy and imaging, amplitude-integrated electroencephalography, immunohistochemistry, and concentration of blood cells and cytokines.ConclusionWe found no indication of neuroprotection by therapeutic hypothermia in newborn piglets following lipopolysaccharide-sensitized hypoxia-ischemia. However, interpretation of the results is limited by the short observation period. Further studies are required to determine the potential clinical implications of these findings

Danish citizens’ preferences for at-home oropharyngeal/nasal SARS-CoV-2 specimen collection

INTRODUCTION: Diagnostic confirmation of SARS-CoV-2 by self-collection of specimens is a reliable method compared to healthcare worker collected samples. Citizen's preferences for collection method are unknown, but at-home collection could have several advantages. METHODS: This study investigated the preference for guided at-home self-collection versus at-hospital specimen collection by healthcare workers. RESULTS: Among the 3,709 participants, an at-home swab collection was the preferred setting for 2,362 (63.7%), as compared with 1,347 (36.3%) reporting a preference for an at-hospital swab procedure. CONCLUSION: A high preference for guided at-home self-collection of oropharyngeal/nasal SARS-CoV-2 Specimen exists and could be a future norm beyond COVID-19