28 research outputs found
Controlled partial embedding of carbon nanotubes within flexible transparent layers
Applications of carbon nanotubes (CNTs) like field emission displays, super-capacitors, and cell growth scaffolds can benefit from controllable embedding of the CNTs in a material such that the CNTs are anchored and protrude a desired length. We demonstrate a simple method for anchoring densely packed, vertically aligned arrays of CNTs into silicone layers using spin-coating, CNT insertion, curing, and growth substrate removal. CNT arrays of 51 and 120 µm in height are anchored into silicone layers of thickness 26 and 36 µm, respectively. Scanning electron microscopy (SEM) and optical microscopy are used to characterize the sample morphology, a 5.5 m s^-1 impinging water jet is used to apply shear stress, and a tensile test shows that the silicone layer detaches from the substrate before the CNTs are ripped from the layer. The CNTs are thus well anchored in the silicone layers. The spin-coating process gives control over layer thickness, and the method should have general applicability to various nanostructures and anchoring materials
A valveless micro impedance pump driven by electromagnetic actuation
Over the past two decades, a variety of micropumps have been explored for various applications in microfluidics such as control of pico- and nanoliter flows for drug delivery as well as chemical mixing and analysis. We present the fabrication and preliminary experimental studies of flow performance on the micro impedance pump, a previously unexplored method of pumping fluid on the microscale. The micro impedance pump was constructed of a simple thin-walled tube coupled at either end to glass capillary tubing and actuated electromagnetically. Through the cumulative effects of wave propagation and reflection originating from an excitation located asymmetrically along the length of the elastic tube, a pressure head can be established to drive flow. Flow rates were observed to be reversible and highly dependent on the profile of the excitation. Micro impedance pump flow studies were conducted in open and closed circuit flow configurations. Maximum flow rates of 16 ml min-1 have been achieved under closed loop flow conditions with an elastic tube diameter of 2 mm. Two size scales with channel diameters of 2 mm and 250 µm were also examined in open circuit flow, resulting in flow rates of 191 µl min-1 and 17 µl min-1, respectively
Identification of genes regulating migration and invasion using a new model of metastatic prostate cancer
Development of a Microimpedance Pump for Pulsatile Flow Transport - Part 1: Flow Characteristics of the Microimpedance Pump. Part 2: A Systematic Study of Steady and Pulsatile Transport in Microscale Cavities
Microfluidics offers an effective means to carry out a wide range of transport processes within a controlled microenvironment by drawing on the benefits imparted by increasing surface area to volume ratio at the microscale. Critical to the impact of microfluidics on integrated devices in the fields of bioengineering and biomedicine is the ability to transport fluids and biomolecules effectively particularly at the size scales involved. In this context a bio-inspired pumping mechanism, the valveless impedance pump, was explored for applications in microfluidics ranging from micro total analysis systems to microchannel cooling. Adhering to the basic principles of the impedance pump mechanism, pumps have been constructed at a variety of size scales from a few centimeters to a few hundred microns. The micro impedance pump is valveless, bidirectional, and can be constructed simply from a wide range of materials. Depending on the size of the pump flow rates range from nL/min to mL/min and pressures can be generated that exceed 20 kPa. Another benefit of the impedance pump is the pulsatile flow output which can be used in the context of microfluidic applications to enhance transport at low Reynolds numbers as well as metering in drug delivery.
Pulsatile flow was therefore investigated as a method of augmenting transport in microfluidic systems. Micro PIV was used to study the affect of both steady and pulsatile flows on transport at low Reynolds number was examined in microscale rectangular cavities. Ventilation of the cavity contents was examined in terms of the residence time or average time a particle remains in the cavity region. Lagrangian coherent structures (LCS) were applied to empirical velocity fields to determine the impact of unsteadiness on time dependent boundaries to fluid transport present in the flow. Experimental results show that there are both frequencies which are beneficial and detrimental to cavity ventilation as well as certain frequencies which more evenly distribute particles originating in the cavity throughout the freestream.</p
Experimental study of the behavior of a valveless impedance pump
When a fluid-filled flexible tube is connected to tubing of different impedance, a net flow in either direction can be induced by periodically pinching the flexible section asymmetrically from the ends. We have experimentally demonstrated a variety of conditions under which pumping occurs; including changes in actuator position, size and pinching frequency, transmural pressure, systemic resistance and materials. Data collected includes dynamic pressure and flow-rate measurements at the inlet and outlet of the pump and ultrasound imaging of the tube walls. The net flow rate is highly sensitive to pinching frequency. The pump does not require a closed loop and can sustain a pressure head. We have also shown that a flexible, yet inelastic material is a sufficient condition for impedance-driven flow. A micro-scaled version of the pump was simultaneously tested demonstrating the feasibility of a miniature design
Rotation of the single-lead ECG along the planar QRS loop for improving morphologic interpretation
International audienc