Formulación de un proyecto social enfocado en promover la participación ciudadana

Trabajo de investigaciónEste trabajo consiste en la formulación de un proyecto social que utiliza la Metodología de Marco Lógico para construir su ejecución, buscando en las necesidades básicas del individuo, es decir; salud, educación y empleo, así como otro tipo de necesidades como son la dignidad, autoestima, aprecio, seguridad y la capacidad de encontrar sentido al mundo que nos rodea.RESUMEN ABSTRACT PALABRAS CLAVE 1. MARCO TEÓRICO 2. OBJETIVO GENERAL 3. OBJETIVOS ESPECÍFICOS 4. DISEÑO METODOLÓGICO 5. RESULTADOS 6. CONCLUSIONES BIBLIOGRAFÍA ANEXOSEspecializaciónEspecialista en Formulación y Evaluación Social y Económica de Proyecto

Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective