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Mesoporous Iron Oxide Synthesized Using Poly(styrene‑<i>b</i>‑acrylic acid‑<i>b</i>‑ethylene glycol) Block Copolymer Micelles as Templates for Colorimetric and Electrochemical Detection of Glucose
Herein,
we report the soft-templated preparation of mesoporous iron oxide
using an asymmetric polyÂ(styrene-<i>b</i>-acrylic acid-<i>b</i>-ethylene glycol) (PS-<i>b</i>-PAA-<i>b</i>-PEG) triblock copolymer. This polymer forms a micelle consisting
of a PS core, a PAA shell, and a PEG corona in aqueous solutions,
which can serve as a soft template. The mesoporous iron oxide obtained
at an optimized calcination temperature of 400 °C exhibited an
average pore diameter of 39 nm, with large specific surface area and
pore volume of 86.9 m<sup>2</sup> g<sup>–1</sup> and 0.218
cm<sup>3</sup> g<sup>–1</sup>, respectively. The as-prepared
mesoporous iron oxide materials showed intrinsic peroxidase-like activities
toward the catalytic oxidation of 3,3′,5,5′-tertamethylbenzidine
(TMB) in the presence of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>). This mimetic feature was further exploited to develop a simple
colorimetric (naked-eye) and electrochemical assay for the detection
of glucose. Both our colorimetric (naked-eye and UV–vis) and
electrochemical assays estimated the glucose concentration to be in
the linear range from 1.0 μM to 100 μM with a detection
limit of 1.0 μM. We envisage that our integrated detection platform
for H<sub>2</sub>O<sub>2</sub> and glucose will find a wide range
of applications in developing various biosensors in the field of personalized
medicine, food-safety detection, environmental-pollution control,
and agro-biotechnology