A Modified Hyrax-Type Expander Is Effective for Distal Bodily Movement of the Maxillary First Molar

Impaction and eruption disturbance of permanent teeth are frequently encountered in orthodontic practice. The canine teeth play an important role both functionally and esthetically. Eruption disturbance of a maxillary canine, if left untreated, can cause not only disturbed jaw movement and esthetic problems, but also root resorption of adjacent permanent teeth, and thus should be diagnosed and treated appropriately. In this report, we present a case of a patient with eruption disturbance of the maxillary left canine in which the maxillary left second molar was extracted and the maxillary left first molar was distally moved with a Hyrax-type expander (Veltri Monolateral Screw®; Leone, Firenze, Italy) designed to enable the distal movement of a unilateral first molar in order to create eruption space for the maxillary left canine, resulting in smooth distal molar movement and alignment of the left maxillary canine in the dental arch. Furthermore, the maxillary third molar was also aligned to achieve a good occlusal relationship without reducing the number of teeth

A Modified Hyrax-Type Expander Is Effective for Distal Bodily Movement of the Maxillary First Molar

Impaction and eruption disturbance of permanent teeth are frequently encountered in orthodontic practice. The canine teeth play an important role both functionally and esthetically. Eruption disturbance of a maxillary canine, if left untreated, can cause not only disturbed jaw movement and esthetic problems, but also root resorption of adjacent permanent teeth, and thus should be diagnosed and treated appropriately. In this report, we present a case of a patient with eruption disturbance of the maxillary left canine in which the maxillary left second molar was extracted and the maxillary left first molar was distally moved with a Hyrax-type expander (Veltri Monolateral Screw®; Leone, Firenze, Italy) designed to enable the distal movement of a unilateral first molar in order to create eruption space for the maxillary left canine, resulting in smooth distal molar movement and alignment of the left maxillary canine in the dental arch. Furthermore, the maxillary third molar was also aligned to achieve a good occlusal relationship without reducing the number of teeth

AirMeet: Communication Support System by Temporarily Sharing Personal Information for Social Gathering

Part 8: Poster and Interactive SessionInternational audienceIn this paper, we propose a system “AirMeet” that supports temporary communication within the venue of the social gathering by limiting personal information to be shared at the time of the social gathering according to its purposes. As a result of carrying out the experiment at the social gatherings, we confirmed that we can promote sharing within the boundary of meeting venue by limiting the personal information participants had not disclosed on the Web. In addition, it confirmed that communication is supported by sharing personal information according to the purpose of the social gathering and using the application in the venue, and it showed the usefulness of the application

Synthesis and Molecular Structure of a Novel Compound Containing a Carbonate-Bridged Hexacalcium Cluster Cation Assembled on a Trimeric Trititanium(IV)-Substituted Wells–Dawson Polyoxometalate

A novel compound containing a hexacalcium cluster cation, one carbonate anion, and one calcium cation assembled on a trimeric trititanium­(IV)-substituted Wells–Dawson polyoxometalate (POM), [{Ca₆(CO₃)­(μ₃-OH)­(OH₂)₁₈}­(P₂W₁₅Ti₃O₆₁)₃Ca­(OH₂)₃]^19‑ (<b>Ca</b>_<b>7</b><b>Ti</b>_<b>9</b><b>Trimer</b>), was obtained as the Na₇Ca₆ salt (<b>NaCa-Ca</b>_<b>7</b><b>Ti</b>_<b>9</b><b>Trimer</b>) by the reaction of calcium chloride with the monomeric trititanium­(IV)-substituted Wells–Dawson POM species “[P₂W₁₅Ti₃O₅₉(OH)₃]^9–” (<b>Ti</b>_<b>3</b><b>Monomer</b>). <b>Ti</b>_<b>3</b><b>Monomer</b> was generated in situ under basic conditions from the separately prepared tetrameric species with bridging Ti­(OH₂)₃ groups and an encapsulated Cl^– ion, [{P₂W₁₅Ti₃O₅₉(OH)₃}₄{μ₃-Ti­(H₂O)₃}₄Cl]^21– (<b>Ti</b>_<b>16</b><b>Tetramer</b>). The Na₇Ca₆ salt of <b>Ca</b>_<b>7</b><b>Ti</b>_<b>9</b><b>Trimer</b> was characterized by complete elemental analysis, thermogravimetric (TG) and differential thermal analyses (DTA), FTIR, single-crystal X-ray structure analysis, and solution ¹⁸³W and ³¹P NMR spectroscopy. X-ray crystallography revealed that the [Ca₆(CO₃)­(μ₃-OH)­(OH₂)₁₈]⁹⁺ cluster cation was composed of six calcium cations linked by one μ₆-carbonato anion and one μ₃-OH^– anion. The cluster cation was assembled, together with one calcium ion, on a trimeric species composed of three tri-Ti­(IV)-substituted Wells–Dawson subunits linked by Ti–O–Ti bonds. <b>Ca</b>_<b>7</b><b>Ti</b>_<b>9</b><b>Trimer</b> is an unprecedented POM species containing an alkaline-earth-metal cluster cation and is the first example of alkaline-earth-metal ions clustered around a titanium­(IV)-substituted POM

Impacts of Glucose-Dependent Insulinotropic Polypeptide on Orthodontic Tooth Movement-Induced Bone Remodeling

Glucose-dependent insulinotropic polypeptide (GIP) exerts extra-pancreatic effects via the GIP receptor (GIPR). Herein, we investigated the effects of GIP on force-induced bone remodeling by orthodontic tooth movement using a closed-coil spring in GIPR-lacking mice (GIPRKO) and wild-type mice (WT). Orthodontic tooth movements were performed by attaching a 10-gf nickel titanium closed-coil spring between the maxillary incisors and the left first molar. Two weeks after orthodontic tooth movement, the distance of tooth movement by coil load was significantly increased in GIPRKO by 2.0-fold compared with that in the WT. The alveolar bone in the inter-root septum from the root bifurcation to the apex of M1 decreased in both the GIPRKO and WT following orthodontic tooth movement, which was significantly lower in the GIPRKO than in the WT. The GIPRKO exhibited a significantly decreased number of trabeculae and increased trabecular separation by orthodontic tooth movement compared with the corresponding changes in the WT. Histological analyses revealed a decreased number of steady-state osteoblasts in the GIPRKO. The orthodontic tooth movement induced bone remodeling, which was demonstrated by an increase in osteoblasts and osteoclasts around the forced tooth in the WT. The GIPRKO exhibited no increase in the number of osteoblasts; however, the number of osteoclasts on the coil-loaded side was significantly increased in the GIPRKO compared with in the WT. In conclusion, our results demonstrate the impacts of GIP on the dynamics of bone remodeling. We revealed that GIP exhibits the formation of osteoblasts and the suppression of osteoclasts in force-induced bone remodeling

Development of Ethyl Methanesulfonate Mutant Edamame Soybean (Glycine max (L.) Merr.) Populations and Forward and Reverse Genetic Screening for Early-Flowering Mutants

Induced mutation is a viable breeding strategy that is widely utilized in the development of elite plant varieties. We aimed to improve a variety of edamame by constructing novel mutant populations using the ethyl methanesulfonate in soybeans (Glycine max (L.) Merr.). In the M2 population, the flowering stage showed a considerable standard deviation compared to the wild type, confirming that the mutant populations had the expected DNA mutations. To identify the DNA mutations in the mutant populations, we used the targeting induced local lesions in genomes (TILLING) method, which is a reverse genetic method, to search for soybean flowering-related gene mutants. A total of 30 mutants from E1, E3, E4, and PhyA1 genes, which are known to be highly effective genes, or their homologous gene for flowering and maturation found in soybean quantitative trait locus analyses were isolated from our TILLING screening. Among these mutants, there were eleven nonsynonymous substitution mutants, one nonsense mutant, and two single nucleotide deletion mutants that could be expected to reduce or eliminate gene function. The e1, e3, and e4 mutants obtained in this study flowered considerably earlier than the wild type. In particular, the e1 mutant with a nonsynonymous substitution flowered approximately 1 month after sowing regardless of the sowing date, and its harvest date was approximately 1 month earlier than that of the wild type. Mutations identified using the TILLING method could not only be used as gel-based DNA markers with the same manipulation method, but the mutations could also be detected as DNA markers by the high-resolution melting method. These results indicate that mutations achieved without chromosome modification by crossbreeding are effective for early and practical improvement of superior varieties and that efficient selection of mutants by reverse genetics is an effective method for the identification of genetic modifications. The edamame mutant populations developed in this study are believed to possess various useful alleles which may be applicable in the search for mutations that lead to improved edamame yield and eating quality beyond the flowering stage

The iron chelating agent, deferoxamine detoxifies Fe(Salen)-induced cytotoxicity

Iron-salen, i.e., μ-oxo-N,N′-bis(salicylidene)ethylenediamine iron (Fe(Salen)) was a recently identified as a new anti-cancer compound with intrinsic magnetic properties. Chelation therapy has been widely used in management of metallic poisoning, because an administration of agents that bind metals can prevent potential lethal effects of particular metal. In this study, we confirmed the therapeutic effect of deferoxamine mesylate (DFO) chelation against Fe(Salen) as part of the chelator antidote efficacy. DFO administration resulted in reduced cytotoxicity and ROS generation by Fe(Salen) in cancer cells. DFO (25 mg/kg) reduced the onset of Fe(Salen) (25 mg/kg)-induced acute liver and renal dysfunction. DFO (300 mg/kg) improves survival rate after systematic injection of a fatal dose of Fe(Salen) (200 mg/kg) in mice. DFO enables the use of higher Fe(Salen) doses to treat progressive states of cancer, and it also appears to decrease the acute side effects of Fe(Salen). This makes DFO a potential antidote candidate for Fe(Salen)-based cancer treatments, and this novel strategy could be widely used in minimally-invasive clinical settings

Treatment of oral cancer using magnetized paclitaxel.

(Fe(Salen)) is an anti-cancer agent with intrinsic magnetic property. Here, we covalently linked Fe(Salen) to paclitaxel (PTX), a widely used anti-cancer drug, to obtain a magnetized paclitaxel conjugate (M-PTX), which exhibited magnetic characteristics for magnet-guided drug delivery and MRI visualization. M-PTX increased apoptosis and G2/M arrest of cultured human oral cancer cell lines in the same manner as PTX. Furthermore, marked contrast intensity was obtained in magnetic resonance imaging (MRI) of M-PTX. In a mouse oral cancer model, a permanent magnet placed on the body surface adjacent to the tumor resulted in distinct accumulation of M-PTX, and the anti-cancer effect was greater than that of M-PTX without the magnet. We believe that this strategy may improve future cancer chemotherapy by providing conventional anti-cancer drugs with novel functionalities such as magnet-guided drug delivery or MRI-based visualization/quantitation of drug distribution