2 research outputs found
Metal-Doped Boron Quantum Dots for Versatile Detection of Lactate and Fluorescence Bioimaging
To improve the stability and fluorescence (FL) of monoelemental
boron nanomaterials, this work put forward a metal-coordination strategy
to explore emerging metal-doped boron quantum dots, Co@BQDs. Through
theoretical calculations, B–Co bonding as predicted can suppress
the B–O reaction and protect the electronic structures of exfoliated
two-dimensional (2D) boron from oxidation and decomposition upon exposure
to oxygen. In experimental studies, Co2+ was added into
a dispersion liquid of bulk boron and subjected to probe sonication
to promote Co2+ adsorption on the surface of exfoliated
2D boron, followed by Co2+ coordination with exposed boron
atoms. Solvothermal treatment of exfoliated 2D boron resulted in the
generation of Co2+-doped 0D boron Co@BQDs. Experimental
results confirm that Co@BQDs have higher colloidal and FL stability
than BQDs as a reference. B–Co bonding formation to suppress
the B–O reaction ensures the high stability of exfoliated boron
structures. A dispersion liquid of Co@BQDs with stable and bright
FL was used for visual FL imaging of solutions and solid substrates.
Based on enzymatic and cascade oxidation-induced FL quenching of Co@BQDs,
a novel FL bio-probe of lactate was explored. This bio-probe, with
a broad detection range of 0.01–10 mM and a low detection limit
of 3.1 μM, enables FL sensing of lactate in biosamples and shows
high detection recoveries of 98.0–102.8%. Moreover, this bio-probe
realized versatile FL imaging and visual detection of lactate in liquid/solid-phase
systems. These results demonstrate great prospects of Co@BQDs as emerging
and efficient imaging reagents for long-term tracking and bioimaging
applications
Ratiometric and Time-Resolved Fluorimetry from Quantum Dots Featuring Drug Carriers for Real-Time Monitoring of Drug Release in Situ
An effective ratiometric and time-resolved
fluorimetry was described. On the basis of Förster resonance
energy transfer (FRET) between semiconductor quantum dots (QDs) and
fluorescent drugs, polyÂ(ethylene glycol)-modified QDs were successfully
prepared and further developed as QDs featuring carriers for real-time
monitoring of drug release in situ