Аналіз впливу мотивуючих факторів на результати діяльності машинобудівних підприємств

У статті обґрунтовано вибір інструментарію факторного аналізу для оцінки впливу мотивуючих чинників на результативні показники діяльності машинобудівних підприємств. Розраховані коефіцієнти кореляції для досліджуваних підприємств. Встановлена ступінь зв’язку факторів з результативним показником.В статье обоснован выбор инструментария факторного анализа для оценки влияния мотивирующих факторов на результативные показатели деятельности машиностроительных предприятий. Рассчитаны коэффициенты корреляции для исследуемых предприятий. Установлена степень связи факторов с результативным показателем.In the article the choice of tool of factor analysis is grounded for the estimation of influence of explaining factors on effective performance of machine-building enterprises indicators. The coefficients of correlation are expected for the probed enterprises. The degree of connection of factors is set with an effective index

Prolonged (post-thaw) shelf life of −80°C frozen AB apheresis plasma

BACKGROUND: Early plasma transfusion is important in the treatment of patients with major hemorrhage. Prolonged shelf life of AB type frozen −80°C and cold-stored (4°C) deep frozen plasma (DFP) will improve strategic stock management, minimize need for resupply, and make pre-hospital implementation more feasible. METHODS AND MATERIALS: Plasma products type AB of different age and origin (−30°C Fresh Frozen [(FFP], −80°C DFP [short (±1 year) and long (±7 year)] stored) were thawed (Day 0), stored at 4°C, and sampled on Days 7 and 14. Additionally, samples of plasma containing blood products (Octaplas LG®, whole blood and platelets) were compared for coagulation factor activity, phospholipid clotting time (PPL), and kaolin TEG during 4°C or 22°C storage. RESULTS: Coagulation profiles of FFP, short- and long-stored −80°C DFP were not significantly different after thaw. Cold storage did not affect fibrinogen, Protein C, and Antithrombin III activities whereas factor V, VII, VIII, and Protein S decreased in all blood products. After 14 days DFP still meets the guidelines for clinical use, except for Protein S (0.4 IU/mL). With exception of Octaplas LG®, phospholipid activity and TEG coagulation were similar between plasma containing blood components during storage. CONCLUSION: AB DFP quality was unaffected by almost 7 years of frozen storage. Quality of thawed 14-day stored AB DFP met, with exception of Protein S, all minimal guidelines which implies that its quality is sufficient for use in the (pre)-hospital (military) environment for treatment of major hemorrhage

The use of cryopreserved platelets in a trauma-induced hemorrhage model

Background: Cryopreserved platelet products can be stored for years and are mainly used in military settings. Following thawing, cryopreserved platelets are activated, resulting in faster clot formation but reduced aggregation in vitro, rendering their efficacy in bleeding unknown. Also, concerns remain on the safety of these products. The aim was to investigate the efficacy and safety of cryopreserved platelets in a rat model of traumatic hemorrhage. Study Design and Methods: After 1 hour of shock, rats (n = 13/group) were randomized to receive a balanced transfusion pack (1:1:1 red blood cell:plasma: platelet) made from syngeneic rat blood, containing either liquid stored platelets or cryopreserved platelets. Primary outcome was the transfusion volume required to obtain a mean arterial pressure (MAP) of 60 mmHg. Secondary outcomes were coagulation as assessed by thromboelastometry (ROTEM®) and organ failure as assessed by biochemistry and histopathology. Results: The transfusion volume to obtain a MAP of 60 mmHg was lower in animals receiving cryopreserved platelets (5.4 [4.1-7.1] mL/kg) compared to those receiving liquid stored platelets (7.5 [6.4-8.5] mL/kg, p < 0.05). ROTEM® clotting times were shorter (45 [41-48] vs. 49 [45-53]sec, p < 0.05), while maximum clot firmness was slightly lower (68 [67-68] vs. 69 [69-71]mm, p < 0.01). Organ failure was similar in both groups. Conclusions: Use of cryopreserved platelets required less transfusion volume to reach a targeted MAP compared to liquid stored platelets, while organ injury was similar. These results provide a rationale for clinical trials with cryopreserved platelets in (traumatic) bleeding

Vergoeding voor (im)materiële schade na de dood: over perte d’une chance de survie en lost years

In het Nederlandse schadevergoedingsrecht fungeert de dood als keerpunt: de direct gekwetste lijdt voor zijn overlijden de schade en na zijn overlijden zijn het diens nabestaanden. De kernvraag van deze bijdrage is of een verschuiving van de focus op schade van nabestaanden naar die op de schade van de gekwetste na de dood, een oplossing zou kunnen bieden voor de kritiek dat de huidige civielrechtelijke sanctie op het veroorzaken van iemands overlijden (te) beperkt is. Deze analyse is gemaakt aan de hand van het Franse concept perte d’une chance de survie, dat in Frankrijk is gepresenteerd als een aparte immateriële schadepost, en de vererving van een Engelse lost years-vordering ten aanzien van het netto-inkomensverlies in de jaren waarin niet gewerkt kan worden. Uit de analyse bleek dat deze veranderingen niet de oplossing bieden voor het bezwaar dat het huidige schadevergoedingsrecht in overlijdensschadezaken beperkt is. Een fundamentele herziening van het systeem door een verschuiving van de focus op de schade van nabestaanden naar die op de vordering van erfgenamen, ligt alleen al daarom niet voor de hand