occurence of left main occlusion on tuesday chronobiology of acute myocardial infarction due to left main disease

Abstract Objectives The existence of a "weekend effect" for onset of acute myocardial infarction has been suggested in the past, but the relation with the culprit vessel has not been investigated. Myocardial infarction due to left main coronary artery lesion represents a particularly serious life-threatening condition. Our study was aimed to assess the chronobiology of admission to the emergency department for acute myocardial infarction considered to be induced by a left main culprit lesion. Methods We retrospectively reviewed patients who experienced an acute myocardial infarction due to a left main culprit lesion between the 1st January 2008 and the 1st January 2018 stratifying them according the day of admission, on the basis on the time of symptom onset; 30-day cardiovascular mortality was also analysed on the basis of the time of symptom onset. Results Out of 1789 patients with acute myocardial infarction, 130 patients (7.2%, 104 males and 26 females, mean age 74.5±8.1 years), had left main disease as the culprit lesion. Tuesday was significantly over-represented as the admission day (p Conclusion The relation between acute myocardial infarction onset and the day of the week is confirmed by our study, which also suggests that in case of a left main lesion some delay of the week-end effect might be expected

Acute Pulmonary Embolism and Paradoxical Embolism in Patients with Patent Foramen Ovale: to Close or Not to Close…That is the Question!

Nowadays, the treatment of patent foramen ovale (PFO) after acute pulmonary embolism (PE) remains matter of speculation. Absence of both randomized trials and recommendations in current international guidelines complicate the decisions making in such patients. In the present manuscript we discuss about the reasons for which PFO should be closed after acute PE.</p

Acute Pulmonary Embolism and Paradoxical Embolism in Patients with Patent Foramen Ovale: to Close or Not to Close…That is the Question!

Nowadays, the treatment of patent foramen ovale (PFO) after acute pulmonary embolism (PE) remains matter of speculation. Absence of both randomized trials and recommendations in current international guidelines complicate the decisions making in such patients. In the present manuscript we discuss about the reasons for which PFO should be closed after acute PE

Ostra niewydolność serca po embolizacji guza nerki. Opis przypadku

Renal cell carcinoma (RCC) is the most common primary malignant renal tumor. The classic triad of symptoms includes palpable abdominal mass, hematuria and flank pain. However, some of the patients diagnosed with RCC first present with paraneoplastic symptoms occurring as a consequence of secretion of various substances from the tumor. We present a case of a woman diagnosed with large kidney tumor, who developed acute heart failure soon after being treated with percutaneous embolization. We discuss toxic myocarditis as one of the possible causes for the acute hemodynamic compromise and the fatal outcome of the patient. Our case report highlights the complexity of this pathology and the importance of awareness of the various possible life-threatening complications.Rak nerkowo-komórkowy jest najczęstszym pierwotnym nowotworem złośliwym nerki. Klasyczna triada objawów z nim związanych obejmuje guz w jamie brzusznej, krwiomocz i ból w okolicy lędźwiowej. Jednak niektórzy pacjenci z rakiem nerkowo-komórkowym najpierw mają objawy paraneoplastyczne wywoływane przez substancje produkowane przez guz. W pracy przedstawiono przypadek kobiety, u której zdiagnozowano duży guz nerki i u której bezpośrednio po jego embolizacji rozwinęły się objawy ostrej niewydolności serca. Jako jedną z możliwych przyczyn ostrych zaburzeń hemodynamicznych i zgonu pacjenta rozważono toksyczne zapalenie mięśnia sercowego. Przedstawiony opis przypadku podkreśla złożoność patologii, jak również potrzebę świadomości różnych możliwych zagrażających życiu powikłań związanych z jego leczeniem

Dyslipidaemia and mortality in COVID-19 patients - a meta-analysis

Background: The prevalence and prognostic implications of pre-existing dyslipidaemia in patients infected by the SARS-CoV-2 remain unclear. Aim: To assess the prevalence and mortality risk in COVID-19 patients with pre-existing dyslipidaemia. Design: Systematic review and meta-Analysis. Methods: Preferred reporting items for systematic reviews and meta-Analyses guidelines were followed in abstracting data and assessing validity. We searched MEDLINE and Scopus to locate all the articles published up to 31 January 2021, reporting data on dyslipidaemia among COVID-19 survivors and non-survivors. The pooled prevalence of dyslipidaemia was calculated using a random-effects model and presenting the related 95% confidence interval (CI), while the mortality risk was estimated using the Mantel-Haenszel random-effect models with odds ratio (OR) and related 95% CI. Statistical heterogeneity was measured using the Higgins I2 statistic. Results: Of about 18 studies, enrolling 74 132 COVID-19 patients (mean age 70.6 years), met the inclusion criteria and were included in the final analysis. The pooled prevalence of dyslipidaemia was 17.5% of cases (95% CI: 12.3-24.3%, P &lt; 0.0001), with high heterogeneity (I2 = 98.7%). Pre-existing dyslipidaemia was significantly associated with higher risk of short-Term death (OR: 1.69, 95% CI: 1.19-2.41, P = 0.003), with high heterogeneity (I2 = 88.7%). Due to publication bias, according to the Trim-And-Fill method, the corrected random-effect ORs resulted 1.61, 95% CI 1.13-2.28, P &lt; 0.0001 (one studies trimmed). Conclusion: Dyslipidaemia represents a major comorbidity in about 18% of COVID-19 patients but it is associated with a 60% increase of short-Term mortality risk

The short-term supplementation of monacolin K improves the lipid and metabolic patterns of hypertensive and hypercholesterolemic subjects at low cardiovascular risk

A nutraceutical compound containing 10 mg of MK appeared to be safe, well tolerated and effective at improving lipid and glucose patterns