300 research outputs found

    Smart cities and heritage conservation: developing a smartheritage agenda for sustainable inclusive communities

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    This paper discusses the potential of current advancements in Information Communication Technologies (ICT) for cultural heritage preservation, valorization and management within contemporary cities. The paper highlights the potential of virtual environments to assess the impacts of heritage policies on urban development. It does so by discussing the implications of virtual globes and crowdsourcing to support the participatory valuation and management of cultural heritage assets. To this purpose, a review of available valuation techniques is here presented together with a discussion on how these techniques might be coupled with ICT tools to promote inclusive governance

    Circular economy and the role of universities in urban regeneration: the case of Ortigia, Syracuse

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    Regeneration processes activate stable regimes of interaction and interdependence among the architectural, economic, cultural and social sub-systems in settlements. The thesis of this paper is that in order to progress towards sustainable and inclusive cities, urban governance should widen the decision-making arena, promoting virtuous circular dynamics based on knowledge transfer, strategic decision making and stakeholders’ engagement. The historic urban landscape is a privileged lab for this purpose. The paper adapts the Triple-Helix model of knowledge-industry-government relationships to interpret the unexpected regimes of interaction between Local Authority and Cultural Heritage Assets triggered in the late 90s by the establishment of a knowledge provider such as a Faculty of Architecture in the highly degraded heritage context of the city of Syracuse, Italy. Following this approach, the authors explain the urban regeneration happened over the last 20 years in the port city of Syracuse, based on knowledge sharing and resources’ protection that promoted processes of social engagement and institutional empowerment for both new residents and entrepreneurs

    “Three-bullets” loaded mesoporous silica nanoparticles for combined photo/chemotherapy

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    This contribution reports the design, preparation, photophysical and photochemical characterization, as well as a preliminary biological evaluation of mesoporous silica nanoparticles (MSNs) covalently integrating a nitric oxide (NO) photodonor (NOPD) and a singlet oxygen (1O2) photosensitizer (PS) and encapsulating the anticancer doxorubicin (DOX) in a noncovalent fashion. These MSNs bind the NOPD mainly in their inner part and the PS in their outer part in order to judiciously exploit the different diffusion radius of the cytotoxic NO and 1O2. Furthermore this silica nanoconstruct has been devised in such a way to permit the selective excitation of the NOPD and the PS with light sources of different energy in the visible window. We demonstrate that the individual photochemical performances of the photoactive components of the MSNs are not mutually affected, and remain unaltered even in the presence of DOX. As a result, the complete nanoconstruct is able to deliver NO and 1O2 under blue and green light, respectively, and to release DOX under physiological conditions. Preliminary biological results performed using A375 cancer cells show a good tolerability of the functionalized MSNs in the dark and a potentiated activity of DOX upon irradiation, due to the effect of the NO photoreleased
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