Évolution des modèles d’élevage de porcs en Europe et impacts sur les performances technico-économiques

L’évolution de la production porcine depuis 2000 est caractérisée par une concentration structurelle très forte dans certains pays. Elle se traduit par une progression rapide des performances techniques du fait, au-delà du progrès génétique, de la disparition des élevages les moins efficaces, de la spécialisation des exploitations, de la modernisation des bâtiments et de l’amélioration consécutive de la situation sanitaire, des conditions de travail du personnel et de vie des animaux. Cette évolution se traduit aussi par une intensification de l’élevage de porcs qui rencontre une opposition croissante dans la société.The evolution of pig production since 2000 is characterized by a structural concentration which is very strong in some countries. In addition to the genetic progress, it results in a rapid increase in technical performance because of the disappearance of the least efficient farms, specialization of farms, modernization of buildings and the resulting improvement in health status, conditions of working for staff and of life for animals. This trend also leads to the intensification of pig farming which meets a growing opposition in society

Micro-RNAs as diagnostic or prognostic markers in human epithelial malignancies

Micro-RNAs (miRs) are important regulators of mRNA and protein expression; the ability of miR expression profilings to distinguish different cancer types and classify their sub-types has been well-described. They also represent a novel biological entity with potential value as tumour biomarkers, which can improve diagnosis, prognosis, and monitoring of treatment response for human cancers. This endeavour has been greatly facilitated by the stability of miRs in formalin-fixed paraffin-embedded (FFPE) tissues, and their detection in circulation. This review will summarize some of the key dysregulated miRs described to date in human epithelial malignancies, and their potential value as molecular bio-markers in FFPE tissues and blood samples. There remain many challenges in this domain, however, with the evolution of different platforms, the complexities of normalizing miR profiling data, and the importance of evaluating sufficiently-powered training and validation cohorts. Nonetheless, well-conducted miR profiling studies should contribute important insights into the molecular aberrations driving human cancer development and progression

Outil d'aide a la specification et a l'implementation de protocoles de transfert

SIGLECNRS T Bordereau / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Hétérogénéité physiologique de l'épithélium de l'épididyme : sécrétion de protons via la H+-ATPase vacuolaire dans les cellules claires et transport d'eau et de solutés via l'aquaporine 9 dans les cellules principales

REIMS-BU Santé (514542104) / SudocSudocFranceF

Evaluation de l'utilisation de la clozapine au Centre hospitalier Sainte-Anne en 2009

CHATENAY M.-PARIS 11-BU Pharma. (920192101) / SudocSudocFranceF

Evaluation de la pertinence de la prescription des antiparkinsoniens chez l'adulte schizophrène au centre hospitalier Sainte-Anne (quelle évolution depuis 2007 ?)

CHATENAY M.-PARIS 11-BU Pharma. (920192101) / SudocSudocFranceF

Prise en charge des troubles bipolaires (étude de faisabilité d'une évaluation des pratiques professionnelles au sein d'un service de psychiatrie)

PARIS-BIUP (751062107) / SudocSudocFranceF

A Pull Approach to Knowledge Management - Using IS as a knowledge indicator to help people know when to look for knowledge reuse

This paper studies the problem of knowledge management and particularly from the perspective of a small & medium enterprises (SME) under the new industrial constraints ». We propose and argue our original approach to knowledge management which really consider some specific needs of SME. This approach starts with knowledge needs of current projects (i.e. pulled by customer demand). We propose a tool that uses the context of knowledge, and particularly the information system (IS), to help people know (by notifying them) when to look for knowledge to reuse without having to previously formalize it. 1. Introduction Management of knowledge is becoming an increasingly important concern of the enterprise [O'Le 98], [McC 98]. However, current solutions in this area do not seem to be convincing to SME [Die 98], [Bart 97], because they do not consider their specific needs [Mah 98-2]; [Mah 97]. Working in close cooperation with KSB Annecy, an SME employing 250 people, we found it necessary to pr..