Technical Evaluation of the Carolo-Cup 2014 - A Competition for Self-Driving Miniature Cars

The Carolo-Cup competition conducted for the eighth time this year, is an international student competition focusing on autonomous driving scenarios implemented on 1:10 scale car models. Three practical sub-competitions have to be realized in this context and represent a complex, interdisciplinary challenge. Hence, students have to cope with all core topics like mechanical development, electronic design, and programming as addressed usually by robotic applications. In this paper we introduce the competition challenges in detail and evaluate the results of all 13 participating teams from the 2014 competition. For this purpose, we analyze technical as well as non-technical configurations of each student group and derive best practices, lessons learned, and criteria as a precondition for a successful participation. Due to the comprehensive orientation of the Carolo-Cup, this knowledge can be applied on comparable projects and related competitions as well

Adjuvant radiotherapy and chemoradiation with gemcitabine after R1 resection in patients with pancreatic adenocarcinoma

Background: The purpose of the study was to evaluate the effect of radiation therapy and chemoradiation with gemcitabine (GEM) after R1 resection in patients with pancreatic adenocarcinoma (PAC). Methods: We performed a retrospective analysis of 25 patients who were treated with postoperative radiotherapy (RT) or chemoradiation (CRT) after surgery with microscopically positive resection margins for primary pancreatic cancer (PAC). Median age was 60 years (range 34 to 74 years), and there were 17 male and 8 female patients. Fractionated RT was applied with a median dose of 49.6 Gy (range 36 to 54 Gy). Eight patients received additional intraoperative radiotherapy (IORT) with a median dose of 12 Gy. Results: Median overall survival (mOS) of all treated patients was 22 months (95% confidence interval (CI) 7.9 to 36.1 months) after date of resection and 21.1 months (95% CI 7.6 to 34.6 months) after start of (C)RT. Median progression-free survival (mPFS) was 13.0 months (95% CI 0.93 to 25 months). Grading (G2 vs. G3, P = 0.005) and gender (female vs. male, P = 0.01) were significantly correlated with OS. There was a significant difference in mPFS between male and female patients (P = 0.008). A total of 11 from 25 patients experienced local tumour progression, and 19 patients were diagnosed with either locoregional or distant failure. Conclusions: We demonstrated that GEM-based CRT can be applied in analogy to neoadjuvant protocols in the adjuvant setting for PAC patients at high risk for disease recurrence after incomplete resection. Patients undergoing additive CRT have a rather good OS and PFS compared to historical control patient groups

Neoadjuvant chemoradiation with Gemcitabine for locally advanced pancreatic cancer

<p>Abstract</p> <p>Introduction</p> <p>To evaluate efficacy and secondary resectability in patients with locally advanced pancreatic cancer (LAPC) treated with neoadjuvant chemoradiotherapy (CRT).</p> <p>Patients and methods</p> <p>A total of 215 patients with locally advanced pancreatic cancer were treated with chemoradiation at a single institution. Radiotherapy was delivered with a median dose of 52.2 Gy in single fractions of 1.8 Gy. Chemotherapy was applied concomitantly as gemcitabine (GEM) at a dose of 300 mg/m²weekly, followed by adjuvant cycles of full-dose GEM (1000 mg/m²). After neoadjuvant CRT restaging was done to evaluate secondary resectability. Overall and disease-free survival were calculated and prognostic factors were estimated.</p> <p>Results</p> <p>After CRT a total of 26% of all patients with primary unresectable LAPC were chosen to undergo secondary resection. Tumour free resection margins could be achieved in 39.2% (R0-resection), R1-resections were seen in 41.2%, residual macroscopic tumour in 11.8% (R2) and in 7.8% resection were classified as Rx. Patients with complete resection after CRT showed a significantly increased median overall survival (OS) with 22.1 compared to 11.9 months in non-resected patients. Median OS and disease-free survival (DFS) of all patients were 12.3 and 8.1 months respectively. In most cases the first site of disease progression was systemic with hepatic (52%) and peritoneal (36%) metastases.</p> <p>Discussion</p> <p>A high percentage of patients with locally advanced pancreatic cancer can undergo secondary resection after gemcitabine-based chemoradiation and has a relative long-term prognosis after complete resection.</p

Modelling and calibrating situation adaptive lane changing and merging behavior on Chinese elevated roads

This paper describes the extension and the calibration of a driver model in SUMO that enables a situation adaptive driver behavior for lane changing and merging processes. The extensions are tailored to improve the representation of Chinese traffic dynamics but are expected to yield improvements for other regions of the world as well. To design and calibrate the model extensions FOT (field operational test) Data is used to analyze which influence critical traffic situations have on driving behavior. The results are discussed and findings for driver models as well as for piloted driving systems are derived. To this end a detailed evaluation of merging and lane change behavior with respect to different traffic situations is conducted. Subsequently the model extensions of emotion-memory and lateral encroachment are explained and its implementation and calibration discussed. Finally the resulting Driver model is validated by using real world data from Chinese elevated road interchanges and merging areas

Laser powder bed fusion additive manufacturing of oxide dispersion strengthened steel using gas atomized reaction synthesis powder

Mechanically alloyed Fe-based alloys with oxide dispersion strengthening have largely dropped out of the marketplace due to high cost related to problems with complex and unreliable processing. Nevertheless, the desirable properties of oxide dispersion strengthened (ODS) steels have motivated research on alternate processing routes aimed at improving processing simplicity and reliability. Powders produced by gas atomization reaction synthesis (GARS) consist of stable Fe-Y intermetallic phases and a Cr surface oxide layer that acts as a chemical reservoir during solid-state processing and heat treatment to form a high density of nano-scale oxides. This research explores the use of Fe GARS powders, with 15 wt% Cr with micro-alloyed additions of 0.15 wt% Y and 0.10% Ti, in laser powder bed fusion (LPBF) additive manufacturing (AM), and evaluates the effectiveness of oxide dispersoid formation in the liquid melt pool. Additional oxygen was introduced by varying the LPBF chamber atmospheres using Ar, Ar + 1 wt% O, Ar + 5 wt% O, and air. Characterization of LPBF consolidated solids demonstrated the formation of a high density of nano-scale Y-Ti oxides in the build microstructures from the GARS precursor powders.This is a manuscript of an article published as Horn, Timothy, Christopher Rock, Djamel Kaoumi, Iver Anderson, Emma White, Tim Prost, Joel Rieken et al. "Laser powder bed fusion additive manufacturing of oxide dispersion strengthened steel using gas atomized reaction synthesis powder." Materials & Design 216 (2022): 110574. DOI: 10.1016/j.matdes.2022.110574. Copyright 2022 The Authors. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0). Posted with permission. DOE Contract Number(s): AC02-07CH11358; AR0001379; AC02-06CH11357; AC05-76RL01830; ECCS-2025064

SUMO 2017 Towards Simulation for Autonomous Mobility

This volume contains the proceedings of the SUMO Conference 2017 which was held from 8th to 10th May 2017 with a focus on autonomous mobility. In the current transition process traffic simulation is the only tool which can give us insights in the mechanisms of traffic in largely automatized traffic scenarios. SUMO as an open source tool provides a wide range of traffic planning and simulation functionalities to support the scientific community. The conference proceedings offer an overview of the applicability of the SUMO tool suite as well as its universal extensibility due to the availability of the source code. The major topic of this fifth edition of the SUMO conference is the calibration of simulation to real world or handbook data as well as communicating networks of intelligent vehicles. A number of contributions cover heterogeneous traffic networks, junction control and new traffic model extensions to the simulation. Subsequent specialized issues such as emission modelling and personal rapid transit simulation are targeted as well. At the conference the international user community exchanged their experiences in using SUMO. With this volume we provide an insight to these experiences as inspiration for further projects with the SUMO suite

DEGRO practical guideline for central nervous system radiation necrosis part&nbsp;1: Classification and a&nbsp;multistep approach for diagnosis.

PURPOSE: The Working Group for Neuro-Oncology of the German Society for Radiation Oncology in cooperation with members of the Neuro-Oncology Working Group of the German Cancer Society aimed to define a&nbsp;practical guideline for the diagnosis and treatment of radiation-induced necrosis (RN) of the central nervous system (CNS). METHODS: Panel members of the DEGRO working group invited experts, participated in a&nbsp;series of conferences, supplemented their clinical experience, performed a&nbsp;literature review, and formulated recommendations for medical treatment of RN including bevacizumab in clinical routine. CONCLUSION: Diagnosis and treatment of RN requires multidisciplinary structures of care and defined processes. Diagnosis has to be made on an interdisciplinary level with the joint knowledge of a&nbsp;neuroradiologist, radiation oncologist, neurosurgeon, neuropathologist, and neuro-oncologist. A&nbsp;multistep approach as an opportunity to review as many characteristics as possible to improve diagnostic confidence is recommended. Additional information about radiotherapy (RT) techniques is crucial for the diagnosis of RN. Misdiagnosis of untreated and progressive RN can lead to severe neurological deficits. In this practice guideline, we propose a&nbsp;detailed nomenclature of treatment-related changes and a&nbsp;multistep approach for their diagnosis