Observation of Galactic Gamma-ray Sources with VERITAS

We report on VERITAS observations at energies above 200 GeV of known or potential galactic gamma-ray sources. The observed objects comprise pulsars, pulsar wind nebulae, high-mass X-ray binaries and gamma-ray sources with unknown counterparts in other wavelengths. Among the highlights are the observation of variable gamma-ray emission from the X-ray binary LS I +61 303 and the detection of MGRO J1906+06/HESS J1906+063, an extended gamma-ray source which could not be associated with any obvious counterpart at lower energies.Comment: Fixed typos in source name

Gamma ray emission and stochastic particle acceleration in galaxy clusters

FERMI (formely GLAST) will shortly provide crucial information on relativistic particles in galaxy clusters. We discuss non-thermal emission in the context of general calculations in which relativistic particles (protons and secondary electrons due to proton-proton collisions) interact with MHD turbulence generated in the cluster volume during cluster mergers. Diffuse cluster-scale radio emission (Radio Halos) and hard X-rays are produced during massive mergers while gamma ray emission, at some level, is expected to be common in galaxy clusters.Comment: 4 pages, 2 Figure, proc. of the 4th Heidelberg International Symposium on High Energy Gamma-ray Astronom

A future very-high-energy view of our Galaxy

The survey of the inner Galaxy with H.E.S.S. was remarkably successful in detecting a wide range of new very-high-energy gamma-ray sources. New TeV gamma-ray emitting source classes were established, although several of the sources remain unidentified, and progress has been made in understanding particle acceleration in astrophysical sources. In this work, we constructed a model of a population of such very-high-energy gamma-ray emitters and normalised the flux and size distribution of this population model to the H.E.S.S.-discovered sources. Extrapolating that population of objects to lower flux levels we investigate what a future array of imaging atmospheric telescopes (IACTs) such as AGIS or CTA might detect in a survey of the Inner Galaxy with an order of magnitude improvement in sensitivity. The sheer number of sources detected together with the improved resolving power will likely result in a huge improvement in our understanding of the populations of galactic gamma-ray sources. A deep survey of the inner Milky Way would also support studies of the interstellar diffuse gamma-ray emission in regions of high cosmic-ray density. In the final section of this paper we investigate the science potential for the Galactic Centre region for studying energy-dependent diffusion with such a future array.Comment: Proceeding of "Heidelberg International Symposium on High Energy Gamma-Ray Astronomy", held in Heidelberg, 7-11 July 2008, submitted to AIP Conference Proceedings. 4 pages, 4 figure

Suzaku observation of TeV blazar the 1ES 1218+304: clues on particle acceleration in an extreme TeV blazar

We observed the TeV blazar 1ES 1218+304 with the X-ray astronomy satellite Suzaku in May 2006. At the beginning of the two-day continuous observation, we detected a large flare in which the 5-10 keV flux changed by a factor of ~2 on a timescale of 5x10^4 s. During the flare, the increase in the hard X-ray flux clearly lagged behind that observed in the soft X-rays, with the maximum lag of 2.3x10^4 s observed between the 0.3-1 keV and 5-10 keV bands. Furthermore we discovered that the temporal profile of the flare clearly changes with energy, being more symmetric at higher energies. From the spectral fitting of multi-wavelength data assuming a one-zone, homogeneous synchrotron self-Compton model, we obtain B~0.047 G, emission region size R = 3.0x10^16 cm for an appropriate beaming with a Doppler factor of delta = 20. This value of B is in good agreement with an independent estimate through the model fit to the observed time lag ascribing the energy-dependent variability to differential acceleration timescale of relativistic electrons provided that the gyro-factor \xi is 10^5.Comment: 11 pages, 3 figures, Accepted for publication in ApJ

Helical motion and the origin of QPO in blazar-type sources

Recent observations and analysis of blazar sources provide strong evidence for (i) the presence of significant periodicities in their lightcurves and (ii) the occurrence of helical trajectories in their radio jets. In scenarios, where the periodicity is caused by differential Doppler boosting effects along a helical jet path, both of these facts may be naturally tied together. Here we discuss four possible driving mechanisms for the occurrence of helical trajectories: orbital motion in a binary system, Newtonian-driven jet precession, internal jet rotation and motion along a global helical magnetic field. We point out that for non-ballistic helical motion the observed period may appear strongly shortened due to classical travel time effects. Finally, the possible relevance of the above mentioned driving mechanisms is discussed for Mkn~501, OJ 287 and AO 0235+16.Comment: 6 pages, 1 figure; presented at the 5th Microquasar Workshop, Beijing, June 2004. Accepted for publication in the Chinese Journal of Astronomy and Astrophysic

BMP7 Gene Transfer via Gold Nanoparticles into Stroma Inhibits Corneal Fibrosis In Vivo

This study examined the effects of BMP7 gene transfer on corneal wound healing and fibrosis inhibition in vivo using a rabbit model. Corneal haze in rabbits was produced with the excimer laser performing -9 diopters photorefractive keratectomy. BMP7 gene was introduced into rabbit keratocytes by polyethylimine-conjugated gold nanoparticles (PEI2-GNPs) transfection solution single 5-minute topical application on the eye. Corneal haze and ocular health in live animals was gauged with stereo- and slit-lamp biomicroscopy. The levels of fibrosis [α-smooth muscle actin (αSMA), F-actin and fibronectin], immune reaction (CD11b and F4/80), keratocyte apoptosis (TUNEL), calcification (alizarin red, vonKossa and osteocalcin), and delivered-BMP7 gene expression in corneal tissues were quantified with immunofluorescence, western blotting and/or real-time PCR. Human corneal fibroblasts (HCF) and in vitro experiments were used to characterize the molecular mechanism mediating BMP7’s anti-fibrosis effects. PEI2-GNPs showed substantial BMP7 gene delivery into rabbit keratocytes in vivo (2×10[superscript 4] gene copies/ug DNA). Localized BMP7 gene therapy showed a significant corneal haze decrease (1.68±0.31 compared to 3.2±0.43 in control corneas; p88%; p<0.0001), and immunoblotting of BMP7-transefected HCFs grown in the presence of TGFβ demonstrated significantly enhanced pSmad-1/5/8 (95%; p<0.001) and Smad6 (53%, p<0.001), and decreased αSMA (78%; p<0.001) protein levels. These results suggest that localized BMP7 gene delivery in rabbit cornea modulates wound healing and inhibits fibrosis in vivo by counter balancing TGFβ1-mediated profibrotic Smad signaling.National Institutes of Health (U.S.) (RO1EB000244)Mason Eye Institute (Research to Prevent Blindness Unrestricted Grant

BMP7 Gene Transfer via Gold Nanoparticles into Stroma Inhibits Corneal Fibrosis \u3cem\u3ein vivo\u3c/em\u3e

This study examined the effects of BMP7 gene transfer on corneal wound healing and fibrosis inhibition in vivo using a rabbit model. Corneal haze in rabbits was produced with the excimer laser performing -9 diopters photorefractive keratectomy. BMP7 gene was introduced into rabbit keratocytes by polyethylimine-conjugated gold nanoparticles (PEI2- GNPs) transfection solution single 5-minute topical application on the eye. Corneal haze and ocular health in live animals was gauged with stereo- and slit-lamp biomicroscopy. The levels of fibrosis [a-smooth muscle actin (aSMA), F-actin and fibronectin], immune reaction (CD11b and F4/80), keratocyte apoptosis (TUNEL), calcification (alizarin red, vonKossa and osteocalcin), and delivered-BMP7 gene expression in corneal tissues were quantified with immunofluorescence, western blotting and/or real-time PCR. Human corneal fibroblasts (HCF) and in vitro experiments were used to characterize the molecular mechanism mediating BMP7’s anti-fibrosis effects. PEI2-GNPs showed substantial BMP7 gene delivery into rabbit keratocytes in vivo (26104 gene copies/ug DNA). Localized BMP7 gene therapy showed a significant corneal haze decrease (1.6860.31 compared to 3.260.43 in control corneas; p,0.05) in Fantes grading scale. Immunostaining and immunoblot analyses detected significantly reduced levels of aSMA (4665% p,0.001) and fibronectin proteins (4865% p,0.01). TUNEL, CD11b, and F4/80 assays revealed that BMP7 gene therapy is nonimmunogenic and nontoxic for the cornea. Furthermore, alizarin red, vonKossa and osteocalcin analyses revealed that localized PEI2-GNP-mediated BMP7 gene transfer in rabbit cornea does not cause calcification or osteoblast recruitment. Immunofluorescence of BMP7-transefected HCFs showed significantly increased pSmad-1/5/8 nuclear localization (.88%; p,0.0001), and immunoblotting of BMP7-transefected HCFs grown in the presence of TGFb demonstrated significantly enhanced pSmad-1/5/8 (95%; p,0.001) and Smad6 (53%, p,0.001), and decreased aSMA (78%; p,0.001) protein levels. These results suggest that localized BMP7 gene delivery in rabbit cornea modulates wound healing and inhibits fibrosis in vivo by counter balancing TGFb1-mediated profibrotic Smad signaling

New Relativistic Particle-In-Cell Simulation Studies of Prompt and Early Afterglows from GRBs

Nonthermal radiation observed from astrophysical systems containing relativistic jets and shocks, e.g., gamma-ray bursts (GRBs), active galactic nuclei (AGNs), and microquasars commonly exhibit power-law emission spectra. Recent PIC simulations of relativistic electron-ion (or electron-positron) jets injected into a stationary medium show that particle acceleration occurs within the downstream jet. In collisionless, relativistic shocks, particle (electron, positron, and ion) acceleration is due to plasma waves and their associated instabilities (e.g., the Weibel (filamentation) instability) created in the shock region. The simulations show that the Weibel instability is responsible for generating and amplifying highly non-uniform, small-scale magnetic fields. These fields contribute to the electron's transverse deflection behind the jet head. The resulting "jitter" radiation from deflected electrons has different properties compared to synchrotron radiation, which assumes a uniform magnetic field. Jitter radiation may be important for understanding the complex time evolution and/or spectra in gamma-ray bursts, relativistic jets in general, and supernova remnants.Comment: : 4 pages, 1 figure and 1 table, typos are corrected, submitted for the Proceedings of The 4th Heidelberg International Symposium on High Energy Gamma-Ray Astronomy, July 7-11, 2008, in Heidelberg, German

A Trigger and Readout Scheme for future Cherenkov Telescope Arrays

The next generation of ground-based gamma-ray observatories, such as e.g. CTA, will consist of about 50-100 telescopes, and cameras with in total ~100000 to ~200000 channels. The telescopes of the core array will cover and effective area of ~ 1 km2 and will be possibly accompanied by a large halo of smaller telescopes spread over about 10 km2 . In order to make maximum use of the stereoscopic approach, a very flexible inter-telescope trigger scheme is needed which allows to couple telescopes that located up to ~1 km apart. The development of a cost effective readout scheme for the camera signals exhibits a major technological challenge. Here we present ideas on a new asynchronous inter-telescope trigger scheme, and a very cost-effective, high-bandwidth frontend to backend data transfer system, both based on standard Ethernet components and an Ethernet front-end interface based on mass production standard FPGAs.Comment: 4 pages, 3 figures ; modified version of article to be published in the proceedings of the "4th Heidelberg International Symposium on High Energy Gamma-Ray Astronomy 2008

Sites for Gamma-ray Astronomy in Argentina

We have searched for possible sites in Argentina for the installation of large air Cherenkov telescope arrays and water Cherenkov systems. At present seven candidates are identified at altitudes from 2500 to 4500 m. The highest sites are located at the Northwest of the country, in La Puna. Sites at 2500 and 3100 m are located in the West at El Leoncito Observatory, with excellent infrastructure. A description of these candidate sites is presented with emphasis on infrastructure and climatology.Comment: Submitted to Proceedings of "4th Heidelberg International Symposium on High Energy Gamma-Ray Astronomy 2008