Utilidad de la β2 microglobulina salival como biomarcador en el diagnóstico del Síndrome de Sjögren.

Introducción. El Síndrome de Sjögren (SS) es una enfermedad autoinmune crónica cuya principal manifestación clínica es la sequedad oral (xerostomía) y ocular (xeroftalmia); se caracteriza por la infiltración mono-nuclear progresiva de las glándulas exocrinas y puede afectar una variedad de órganos y sistemas; esta enfermedad tiene un diagnóstico complejo, con un impacto en la calidad de vida de los enfermos. El objetivo de este trabajo fue determinar la utilidad de l

Salivary β2-microglobulin positively correlates with ESSPRI in patients with primary Sjögren's syndrome

Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disorder largely distinguished by lymphocytic exocrinopathy.1 Salivary and lachrymal glands are mainly impaired in pSS. Saliva is therefore considered an optimal biological fluid that closely reflects the underlying autoimmune exocrinopathy.1,2 For instance, in those wit

Salivary rheumatoid factor in primary and secondary Sjögren’s syndrome

Sjögren's syndrome is a chronic autoimmune disease, characterized by the presence of hyposalivation and xerophthalmia, which in addition to other factors is diagnosed by the presence of rheumatoid factor in blood. The objective of the present study is to evaluate the presence of rheumatoid factor (IgG-IgM) in the saliva of patients with primary and secondary Sjögren's syndrome. Materials and methods: Forty samples from patients with primary and secondary Sjögren's syndrome previously diagnosed by the Arthritis and Rheumatism Specialist Center of the Autonomous University of Nuevo Leon were analyzed. Samples were taken from the saliva using the Carlson-Crittenden device to evaluate the IgG-IgM immunocomplex using the ELISA method. Results: No significant difference was found between the presence of IgM in primary (0.099±0.016) and secondary Sjögren syndrome (0.098±0.017), however, a high presence of IgG was found in the group of patients with secondary Sjögren's syndrome (0.134±0.054). Conclusion: The search for diagnostic tools using salivary biomarkers has come with economic and clinical advantages, however, in the present study no significant changes were found in salivary rheumatoid factor between both groups