Coastal cliff ground motions and response to extreme storm waves

Coastal cliff erosion from storm waves is observed worldwide, but the processes are notoriously difficult to measure during extreme storm wave conditions when most erosion normally occurs, limiting our understanding of cliff processes. Over January–February 2014, during the largest Atlantic storms in at least 60 years with deepwater significant wave heights of 6–8 m, cliff-top ground motions showed vertical ground displacements in excess of 50–100 µm; an order of magnitude larger than observations made previously. Repeat terrestrial laser scanner surveys over a 2 week period encompassing the extreme storms gave a cliff face volume loss of 2 orders of magnitude larger than the long-term erosion rate. The results imply that erosion of coastal cliffs exposed to extreme storm waves is highly episodic and that long-term rates of cliff erosion will depend on the frequency and severity of extreme storm wave impacts

Testing Gait with Ankle-Foot Orthoses in Children with Cerebral Palsy by Using Functional Mixed-Effects Analysis of Variance

Dr Morrissey is part funded by the NIHR/HEE Senior Clinical Lecturer scheme. Tis report presents independent research part-funded by the National Institute for Health Research (NIHR) CAT SCL-2013-04-00

Visualisation to enhance biomechanical tuning of ankle-foot orthoses (AFOs) in stroke: study protocol for a randomised controlled trial

There are a number of gaps in the evidence base for the use of ankle-foot orthoses for stroke patients. Three dimensional motion analysis offers an ideal method for objectively obtaining biomechanical gait data from stroke patients, however there are a number of major barriers to its use in routine clinical practice. One significant problem is the way in which the biomechanical data generated by these systems is presented. Through the careful design of bespoke biomechanical visualisation software it may be possible to present such data in novel ways to improve clinical decision making, track progress and increase patient understanding in the context of ankle-foot orthosis tuning

A systematic review to determine best practice reporting guidelines for AFO interventions in studies involving children with cerebral palsy

Studies which have examined the effects of ankle-foot orthoses (AFOs) on children with cerebral palsy (CP) often report insufficient detail about the participants, devices and testing protocols. The aim of this systematic review was to evaluate the level and quality of detail reported about these factors in order to generate best practice guidelines for reporting of future studies. A systematic search of the literature was conducted to identify studies which examined any outcome measure relating to AFO use in children with CP. A customized checklist was developed for data extraction and quality assessment. There was substantial variability in the level and quality of detail reported across the 41-paper yield. Many papers reported insufficient detail to allow synthesis of outcomes across studies. The findings of this review have been used to generate guidelines for best practice of reporting for AFO intervention studies. It is important to ensure homogeneity of gait pattern in a subject sample or to subdivide a sample to investigate the possibility that heterogeneity affected results. It is also important to describe the orthosis in sufficient detail that the device can be accurately replicated because differences in designs have been shown to affect outcomes. These guidelines will help researchers provide more systematic and detailed reports and thereby permit future reviewers to more accurately assess both the reporting and quality of orthotic interventions, and will facilitate synthesis of literature to enhance the evidence base

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ABSTRACT: (R,S)-2-lodooctane and (R,S)-2-bromooctane were found to be substrates for the glutathione S-transferases from rat liver