Interview by Kwok Ming Fung

Mr. Sung in interviewed with me at 3/F conference room, General Education Building, Lingnan College on 19th April. He talks with a great deal of feeling about his childhood. It sounds interesting. He has 7 brothers and lives with his parent and his grandmother during his childhood. His father is work in business field and his mother is housewife and his grandmother is very traditional women. Thus his family is not poor. His mother and his elder brothers do not care the finical support of his family so that Mr. Sung and his brothers no need to work outside when they were small can only focus on their studying. When he was studing primary school, he had been changed from original scholl to a new one because his academic result is not good. It is quite difficult for him to adopt the new environment. Forunately, he familars with his classmate no longer via playing basketball and feeding little animal such as rabbit. After promoting secondary school, he felt that there are quite great pressure came from assessment and serious teacher. On the other hand, the good academic result of his elder brother is one of the major sources of pressure. He gradually looks after and concern about his smaller brothers when he was growing

動的刺激による視知覚の歪みに関する研究

学位の種別:課程博士University of Tokyo(東京大学

A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation

Background: Nasopharyngeal carcinoma (NPC) is an epithelial malignancy strongly associated with Epstein-Barr virus (EBV). AT13387 is a novel heat shock protein 90 (Hsp90) inhibitor, which inhibits the chaperone function of Hsp90 and reduces expression of Hsp90-dependent client oncoproteins. This study aimed to evaluate both the in vitro and in vivo antitumor effects of AT13387 in the EBV-positive NPC cell line C666-1.Results: Our results showed that AT13387 inhibited C666-1 cell growth and induced cellular senescence with the downregulation of multiple Hsp90 client oncoproteins EGFR, AKT, CDK4, and restored the protein expression of negative cell cycle regulator p27. We also studied the ability of AT13387 to restore p27 expression by downregulation of AKT and the p27 ubiquitin mediator, Skp2, using AKT inhibitor and Skp2 siRNA. In the functional study, AT13387 inhibited cell migration with downregulation of a cell migration regulator, HDAC6, and increased the acetylation and stabilization of α-tubulin. We also examined the effect of AT13387 on putative cancer stem cells (CSC) by 3-D tumor sphere formation assay. AT13387 effectively reduced both the number and size of C666-1 tumor spheres with decreased expression of NPC CSC-like markers CD44 and SOX2. In the in vivo study, AT13387 significantly suppressed tumor formation in C666-1 NPC xenografts.Conclusion: AT13387 suppressed cell growth, cell migration, tumor sphere formation and induced cellular senescence on EBV-positive NPC cell line C666-1. Also, the antitumor effect of AT13387 was demonstrated in an in vivo model. This study provided experimental evidence for the preclinical value of using AT13387 as an effective antitumor agent in treatment of NPC. © 2013 Chan et al.; licensee BioMed Central Ltd.published_or_final_versio

The roles of indoor plazas in Hong Kong

published_or_final_versionUrban DesignMasterMaster of Urban Desig

Are recognition errors and deceptive responses differentiable?

published_or_final_versionPsychologyMasterMaster of Philosoph

Visual Spatial Attention Skills and Holistic Processing in High School StudentsWith and Without Dyslexia

Visual-spatial attention has been shown to influence literacy development, yet studies investigating its influence on readingin non-alphabetic scripts such as Chinese are scarce, despite recent studies demonstrating orthographic and visuo-spatialskills to be key deficits in people with dyslexia in Chinese. Here, we investigate visual-spatial processing skills in Chi-nese adolescents by measuring their 1) exogenous and endogenous attentional orienting, and 2) holistic processinga phe-nomenon typically demonstrated in face perceptionin Chinese character recognition. Compared with typically developingstudents, Chinese high-school students with dyslexia showed deficits in both endogenous and exogenous visual-spatialattention. Dyslexics also perceived characters more holistically than the controls, suggesting that they selectively attendedto individual components within Chinese characters less readily. These results demonstrated irregularities in visual-spatialprocessing skills in students in dyslexia. This study provides implications for reading intervention programs in order tofacilitate selective attention to character components to enhance literacy

Incomplete Colonoscopy: Maximizing Completion Rates of Gastroenterologists

BACKGROUND Cecal intubation is one of the goals of a quality colonoscopy; however, many factors increasing the risk of incomplete colonoscopy have been implicated. The implications of missed pathology and the demand on health care resources for return colonoscopies pose a conundrum to many physicians. The optimal course of action after incomplete colonoscopy is unclear

Diagnostic yield of Capsule Endoscopy in the Setting of Iron Deficiency Anemia without Evidence of Gastrointestinal Bleeding

BACKGROUND: The diagnostic yield of capsule endoscopy (CE) in the setting of iron deficiency anemia (IDA) without evidence of occult/overt bleeding has been questioned. Often, these patients have nongastrointestinal causes of iron deficiency but undergo CE to exclude a potential small bowel source