Konzeptionierung eines digitalen webbasierten Antragsportals in der NCTGewebebank Heidelberg

An der NCT-Gewebebank in Heidelberg werden große Mengen menschlichen Gewebes vorgehalten, welche von Forschern hauptsächlich im Rahmen der Tumorforschung verwendet werden können. Da jede Dienstleistung im Zusammenhang mit diesem Gewebe, sowie die Herausgabe dessen zuerst bewilligt werden muss, müssen die forschenden Ärzte und Wissenschaftler einen Antrag an die Gewebebank stellen. Die Antragsstellung erfolgt zum aktuellen Zeitpunkt über ein Online bereit gestelltes Formular, welches im besten Falle digital korrekt ausgefüllt, ausgedruckt und unterschrieben an das Sekretariat der NCT-Gewebebank geschickt wird. Da die Anträge dort wieder von Hand digitalisiert werden, soll der Vorgang online erfolgen und so die Antragsverwaltung erleichtern, sowie weniger anfällig für Fehler machen. Im Rahmen dieser Bachelorarbeit soll ein Konzept entwickelt werden, wie ein Antragsportal funktionieren kann, über das die Forscher online Anträge stellen können. Diese Arbeit ist auf die folgenden Ziele ausgerichtet: - Modellierung des aktuellen Zustands des Prozesses der Antragstellung - Modellierung eines möglichen zukünftigen Prozesses - Vorstellung der möglichen Verbesserungen im Prozess - Konzeptionierung eines Antragsportals - Analyse der Umsetzung dieses Portals mit praktischen Ansätze

Voltage correction factors for air-insulated transmission lines operating in high-Altitude regions to limit corona activity: a review

Nowadays there are several transmission lines projected to be operating in high-altitude regions. It is well known that the installation altitude has an impact on the dielectric behavior of air-insulated systems. As a result, atmospheric and voltage correction factors must be applied in air-insulated transmission systems operating in high-altitude conditions. This paper performs an exhaustiveliteraturereview,includingstate-of-the-artresearchpapersandInternationalStandardsof theavailablecorrectionfactorstolimitcoronaactivityandensureproperperformancewhenplanning air-insulated transmission lines intended for high-altitude areas. It has been found that there are substantial differences among the various correction methods, differences that are more evident at higher altitudes. Most high-voltage standards were not conceived to test samples to be installed in high-altitude regions and, therefore, most high-voltage laboratories are not ready to face this issue, since more detailed information is required. It is proposed to conduct more research on this topic so that the atmospheric corrections and altitude correction factors found in the current International Standards can be updated and/or modified so that high-voltage components to be installed in high-altitude regions can be tested with more accuracy, taking into account their insulation structure.Peer ReviewedPostprint (published version

Renal Safety of Hydroxyethyl starch 130/0.42 After Cardiac Surgery: A Retrospective Cohort Analysis

Introduction!#!The risk for renal complications from hydroxyethyl starch 130/0.42 (HES) impacts treatment decisions in patients after cardiac surgery.!##!Objective!#!The objective of this study was to determine the impact of postoperatively administered HES on renal function and 90-day mortality compared to sole crystalloid administration in patients after elective cardiac surgery.!##!Methods!#!Using electronic health records from a university hospital, confounding-adjusted models analyzed the associations between postoperative HES administration and the occurrence of postoperative acute kidney injury. In addition, 90-day mortality was evaluated. The impact of HES dosage and timing on renal function on trajectories of estimated glomerular filtration rates over the postoperative period was investigated using linear mixed-effects models.!##!Results!#!Overall 1009 patients (45.0%) experienced acute kidney injury. Less acute kidney injury occurred in patients receiving HES compared with patients receiving only crystalloids for fluid resuscitation (43.7% vs 51.2%, p = 0.008). In multivariate acute kidney injury models, HES had a protective association (odds ratio: 0.89; 95% confidence interval 0.82-0.96). Crystalloids were not as protective as HES (odds ratio: 0.98; 95% confidence interval 0.95-1.00). There was no association between HES and 90-day mortality (odds ratio: 1.05; 95% confidence interval 0.88-1.25). Renal function trajectories were dose dependent and biphasic, HES appeared to slow down the late postoperative decline.!##!Conclusions!#!This study showed no association between HES and the postoperative occurrence of acute kidney injury and thus further closes the evidence gap on HES safety in cardiac surgery patients. Although this was a retrospective cohort study, the results indicated that HES might be safely administered to cardiac surgery patients with regard to renal outcomes, especially if it was administered early and dosed appropriately