Time to prescription of warfarin following new diagnosis of atrial fibrillation.

<p>This figure depicts the cumulative percentage of warfarin-eligible patients (N = 440) who received a prescription for warfarin in the first 30 days following the initial ECG showing atrial fibrillation. The difference between groups was not statistically significant (p = 0.74).</p

Screen shot of topic-specific information in the MayoExpert knowledge delivery system.

<p>The link in the EMR message would take providers to this screen.</p

Demographic information for patients with newly-diagnosed atrial fibrillation.

<p>* p<0.05</p><p>^† Warfarin-eligible = no active bleeding and no use of warfarin at admission.</p><p>Demographic information for patients with newly-diagnosed atrial fibrillation.</p

Screen shot of the EMR notification message.

<p>Note that the "patient" in this screen shot is not a real person. The link would take them directly to topic-specific information in the MayoExpert knowledge delivery system (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0122153#pone.0122153.g002" target="_blank">Fig 2</a>).</p

Mechanistic insights into transient severe mitral regurgitation

<p>Acute mitral regurgitation (AMR), a known complication of acute coronary syndromes, is usually associated with posterior papillary muscle dysfunction/rupture. In severe cases, management of AMR requires surgical intervention. Reversible severe AMR in patients in the absence of left ventricular systolic dysfunction and coronary artery stenosis may result from processes which cause transient subendocardial ischemia, such as intermittent episodes of hypotension or coronary artery vasospasm. We present two cases of reversible transient AMR due to subendocardial and/or endocardial ischemia, both of which offer insight into the mechanism of transient severe AMR.</p