Instability of the symmetric Couette-flow in a granular gas: hydrodynamic field profiles and transport

We investigate the inelastic hard disk gas sheared by two parallel bumpy walls (Couette-flow). In our molecular dynamic simulations we found a sensitivity to the asymmetries of the initial condition of the particle places and velocities and an asymmetric stationary state, where the deviation from (anti)symmetric hydrodynamic fields is stronger as the normal restitution coefficient decreases. For the better understanding of this sensitivity we carried out a linear stability analysis of the former kinetic theoretical solution [Jenkins and Richman: J. Fluid. Mech. {\bf 171} (1986)] and found it to be unstable. The effect of this asymmetry on the self-diffusion coefficient is also discussed.Comment: 9 pages RevTeX, 14 postscript figures, sent to Phys. Rev.

Analysis of hadronic invariant mass spectrum in inclusive charmless semileptonic B decays

We make an analysis of the hadronic invariant mass spectrum in inclusive charmless semileptonic B meson decays in a QCD-based approach. The decay width is studied as a function of the invariant mass cut. We examine their sensitivities to the parameters of the theory. The theoretical uncertainties in the determination of $|V_{ub}|$ from the hadronic invariant mass spectrum are investigated. A strategy for improving the theoretical accuracy in the value of $|V_{ub}|$ is described.Comment: 13 pages, 5 Postscript figure

Long distance c→uγc \to u \gamma effects in weak radiative decays of D-mesons

We present a detailed analysis of the $D \to V \gamma$ transitions, using a model which combines heavy quark effective theory and the chiral Lagrangian approach and includes symmetry breaking. We notice that in addition to the previously considered s - channel annihilation and t - channel W - exchange, there is a long distance penguin - like $c \to u \gamma$ contribution in the t - channel of Cabibbo - suppressed modes. Its magnitude is determined by the size of symmetry breaking which we calculate with a vector dominance approach. Although smaller in magnitude, the penguin - like contribution would lead to sizeable effects in case of cancellations among the other contributions to the amplitude. Thus, it may invalidate suggested tests for beyond the standard model effects in these decays. We also indicate the range of expectations for the branching ratios of various $D \to V \gamma$ modes.Comment: 28 pages, Latex, 2 Figure

The conservation status of the world’s freshwater molluscs

With the biodiversity crisis continuing unchecked, we need to establish levels and drivers of extinction risk, and reassessments over time, to effectively allocate conservation resources and track progress towards global conservation targets. Given that threat appears particularly high in freshwaters, we assessed the extinction risk of 1428 randomly selected freshwater molluscs using the IUCN Red List Categories and Criteria, as part of the Sampled Red List Index project. We show that close to one-third of species in our sample are estimated to be threatened with extinction, with highest levels of threat in the Nearctic, Palearctic and Australasia and among gastropods. Threat levels were higher in lotic than lentic systems. Pollution (chemical and physical) and the modification of natural systems (e.g. through damming and water abstraction) were the most frequently reported threats to freshwater molluscs, with some regional variation. Given that we found little spatial congruence between species richness patterns of freshwater molluscs and other freshwater taxa, apart from crayfish, new additional conservation priority areas emerged from our study. We discuss the implications of our findings for freshwater mollusc conservation, the adequacy of a sampled approach and important next steps to estimate trends in freshwater mollusc extinction risk over time

An algorithmic approach to the existence of ideal objects in commutative algebra

The existence of ideal objects, such as maximal ideals in nonzero rings, plays a crucial role in commutative algebra. These are typically justified using Zorn's lemma, and thus pose a challenge from a computational point of view. Giving a constructive meaning to ideal objects is a problem which dates back to Hilbert's program, and today is still a central theme in the area of dynamical algebra, which focuses on the elimination of ideal objects via syntactic methods. In this paper, we take an alternative approach based on Kreisel's no counterexample interpretation and sequential algorithms. We first give a computational interpretation to an abstract maximality principle in the countable setting via an intuitive, state based algorithm. We then carry out a concrete case study, in which we give an algorithmic account of the result that in any commutative ring, the intersection of all prime ideals is contained in its nilradical

Semileptonic B decays to excited charmed mesons

Exclusive semileptonic B decays into excited charmed mesons are investigated at order $\Lambda_{QCD}/m_Q$ in the heavy quark effective theory. Differential decay rates for each helicity state of the four lightest excited $D$ mesons ($D_1$, $D_2^*$, $D_0^*$, and $D_1^*$) are examined. At zero recoil, $\Lambda_{QCD}/m_Q$ corrections to the matrix elements of the weak currents can be written in terms of the leading Isgur-Wise functions for the corresponding transition and meson mass splittings. A model independent prediction is found for the slope parameter of the decay rate into helicity zero $D_1$ at zero recoil. The differential decay rates are predicted, including $\Lambda_{QCD}/m_Q$ corrections with some model dependence away from zero recoil and including order $\alpha_s$ corrections. Ratios of various exclusive branching ratios are computed. Matrix elements of the weak currents between $B$ mesons and other excited charmed mesons are discussed at zero recoil to order $\Lambda_{QCD}/m_Q$. These amplitudes vanish at leading order, and can be written at order $\Lambda_{QCD}/m_Q$ in terms of local matrix elements. Applications to $B$ decay sum rules and factorization are presented.Comment: 39 pages revtex including 10 figures, uses epsf. Substantial improvements throughout the pape

First normal stress difference and crystallization in a dense sheared granular fluid

The first normal stress difference (${\mathcal N}_1$) and the microstructure in a dense sheared granular fluid of smooth inelastic hard-disks are probed using event-driven simulations. While the anisotropy in the second moment of fluctuation velocity, which is a Burnett-order effect, is known to be the progenitor of normal stress differences in {\it dilute} granular fluids, we show here that the collisional anisotropies are responsible for the normal stress behaviour in the {\it dense} limit. As in the elastic hard-sphere fluids, ${\mathcal N}_1$ remains {\it positive} (if the stress is defined in the {\it compressive} sense) for dilute and moderately dense flows, but becomes {\it negative} above a critical density, depending on the restitution coefficient. This sign-reversal of ${\mathcal N}_1$ occurs due to the {\it microstructural} reorganization of the particles, which can be correlated with a preferred value of the {\it average} collision angle $\theta_{av}=\pi/4 \pm \pi/2$ in the direction opposing the shear. We also report on the shear-induced {\it crystal}-formation, signalling the onset of fluid-solid coexistence in dense granular fluids. Different approaches to take into account the normal stress differences are discussed in the framework of the relaxation-type rheological models.Comment: 21 pages, 13 figure

Comparative Effectiveness of a Technology-Facilitated Depression Care Management Model in Safety-Net Primary Care Patients With Type 2 Diabetes: 6-Month Outcomes of a Large Clinical Trial.

BACKGROUND: Comorbid depression is a significant challenge for safety-net primary care systems. Team-based collaborative depression care is effective, but complex system factors in safety-net organizations impede adoption and result in persistent disparities in outcomes. Diabetes-Depression Care-management Adoption Trial (DCAT) evaluated whether depression care could be significantly improved by harnessing information and communication technologies to automate routine screening and monitoring of patient symptoms and treatment adherence and allow timely communication with providers. OBJECTIVE: The aim of this study was to compare 6-month outcomes of a technology-facilitated care model with a usual care model and a supported care model that involved team-based collaborative depression care for safety-net primary care adult patients with type 2 diabetes. METHODS: DCAT is a translational study in collaboration with Los Angeles County Department of Health Services, the second largest safety-net care system in the United States. A comparative effectiveness study with quasi-experimental design was conducted in three groups of adult patients with type 2 diabetes to compare three delivery models: usual care, supported care, and technology-facilitated care. Six-month outcomes included depression and diabetes care measures and patient-reported outcomes. Comparative treatment effects were estimated by linear or logistic regression models that used generalized propensity scores to adjust for sampling bias inherent in the nonrandomized design. RESULTS: DCAT enrolled 1406 patients (484 in usual care, 480 in supported care, and 442 in technology-facilitated care), most of whom were Hispanic or Latino and female. Compared with usual care, both the supported care and technology-facilitated care groups were associated with significant reduction in depressive symptoms measured by scores on the 9-item Patient Health Questionnaire (least squares estimate, LSE: usual care=6.35, supported care=5.05, technology-facilitated care=5.16; P value: supported care vs usual care=.02, technology-facilitated care vs usual care=.02); decreased prevalence of major depression (odds ratio, OR: supported care vs usual care=0.45, technology-facilitated care vs usual care=0.33; P value: supported care vs usual care=.02, technology-facilitated care vs usual care=.007); and reduced functional disability as measured by Sheehan Disability Scale scores (LSE: usual care=3.21, supported care=2.61, technology-facilitated care=2.59; P value: supported care vs usual care=.04, technology-facilitated care vs usual care=.03). Technology-facilitated care was significantly associated with depression remission (technology-facilitated care vs usual care: OR=2.98, P=.04); increased satisfaction with care for emotional problems among depressed patients (LSE: usual care=3.20, technology-facilitated care=3.70; P=.05); reduced total cholesterol level (LSE: usual care=176.40, technology-facilitated care=160.46; P=.01); improved satisfaction with diabetes care (LSE: usual care=4.01, technology-facilitated care=4.20; P=.05); and increased odds of taking an glycated hemoglobin test (technology-facilitated care vs usual care: OR=3.40, P\u3c.001). CONCLUSIONS: Both the technology-facilitated care and supported care delivery models showed potential to improve 6-month depression and functional disability outcomes. The technology-facilitated care model has a greater likelihood to improve depression remission, patient satisfaction, and diabetes care quality

Quantum value indefiniteness

The indeterministic outcome of a measurement of an individual quantum is certified by the impossibility of the simultaneous, definite, deterministic pre-existence of all conceivable observables from physical conditions of that quantum alone. We discuss possible interpretations and consequences for quantum oracles.Comment: 19 pages, 2 tables, 2 figures; contribution to PC0

The Rho GDI Rdi1 regulates Rho GTPases by distinct mechanisms

© 2008 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,. the appearance of) the edited manuscript in an online issue of MBoC, the nonexclusive right to copy, distribute, or display the manuscript subject to the terms of the Creative Commons–Noncommercial–Share Alike 3.0 Unported license (http://creativecommons.org/licenses/by-nc-sa/3.0).The small guanosine triphosphate (GTP)-binding proteins of the Rho family are implicated in various cell functions, including establishment and maintenance of cell polarity. Activity of Rho guanosine triphosphatases (GTPases) is not only regulated by guanine nucleotide exchange factors and GTPase-activating proteins but also by guanine nucleotide dissociation inhibitors (GDIs). These proteins have the ability to extract Rho proteins from membranes and keep them in an inactive cytosolic complex. Here, we show that Rdi1, the sole Rho GDI of the yeast Saccharomyces cerevisiae, contributes to pseudohyphal growth and mitotic exit. Rdi1 interacts only with Cdc42, Rho1, and Rho4, and it regulates these Rho GTPases by distinct mechanisms. Binding between Rdi1 and Cdc42 as well as Rho1 is modulated by the Cdc42 effector and p21-activated kinase Cla4. After membrane extraction mediated by Rdi1, Rho4 is degraded by a novel mechanism, which includes the glycogen synthase kinase 3β homologue Ygk3, vacuolar proteases, and the proteasome. Together, these results indicate that Rdi1 uses distinct modes of regulation for different Rho GTPases.Deutsche Forschungsgemeinschaf