81 research outputs found
Neutron to proton ratios of quasiprojectile and midrapidity emission in the Zn + Zn reaction at 45 MeV/nucleon
Simultaneous measurement of both neutrons and charged particles emitted in
the reaction Zn + Zn at 45 MeV/nucleon allows comparison of the
neutron to proton ratio at midrapidity with that at projectile rapidity. The
evolution of N/Z in both rapidity regimes with increasing centrality is
examined. For the completely re-constructed midrapidity material one finds that
the neutron-to-proton ratio is above that of the overall Zn + Zn
system. In contrast, the re-constructed ratio for the quasiprojectile is below
that of the overall system. This difference provides the most complete evidence
to date of neutron enrichment of midrapidity nuclear matter at the expense of
the quasiprojectile
Dual-frequency VLBI study of Centaurus A on sub-parsec scales
Centaurus A is the closest active galactic nucleus. High resolution imaging
using Very Long Baseline Interferometry (VLBI) enables us to study the spectral
and kinematic behavior of the radio jet-counterjet system on sub-parsec scales,
providing essential information for jet emission and formation models. Our aim
is to study the structure and spectral shape of the emission from the
central-parsec region of Cen A. As a target of the Southern Hemisphere VLBI
monitoring program TANAMI (Tracking Active Galactic Nuclei with Milliarcsecond
Interferometry), VLBI observations of Cen A are made regularly at 8.4 and 22.3
GHz with the Australian Long Baseline Array (LBA) and associated telescopes in
Antarctica, Chile, and South Africa. The first dual-frequency images of this
source are presented along with the resulting spectral index map. An angular
resolution of 0.4 mas x 0.7 mas is achieved at 8.4 GHz, corresponding to a
linear scale of less than 0.013 pc. Hence, we obtain the highest resolution
VLBI image of Cen A, comparable to previous space-VLBI observations. By
combining with the 22.3 GHz image, which has been taken without contributing
transoceanic baselines at somewhat lower resolution, we present the
corresponding dual-frequency spectral index distribution along the sub-parsec
scale jet revealing the putative emission regions for recently detected
gamma-rays from the core region by Fermi/LAT. We resolve the innermost
structure of the milliarcsecond scale jet and counterjet system of Cen A into
discrete components. The simultaneous observations at two frequencies provide
the highest resolved spectral index map of an AGN jet allowing us to identify
multiple possible sites as the origin of the high energy emission.Comment: 5 pages, 3 figures (1 color); A&A, accepte
Molecular Cause and Functional Impact of Altered Synaptic Lipid Signaling Due to a \u3cem\u3eprg-1\u3c/em\u3e Gene SNP
Loss of plasticity‐related gene 1 (PRG‐1), which regulates synaptic phospholipid signaling, leads to hyperexcitability via increased glutamate release altering excitation/inhibition (E/I) balance in cortical networks. A recently reported SNP in prg‐1 (R345T/mutPRG‐1) affects ~5 million European and US citizens in a monoallelic variant. Our studies show that this mutation leads to a loss‐of‐PRG‐1 function at the synapse due to its inability to control lysophosphatidic acid (LPA) levels via a cellular uptake mechanism which appears to depend on proper glycosylation altered by this SNP. PRG‐1+/− mice, which are animal correlates of human PRG‐1+/mut carriers, showed an altered cortical network function and stress‐related behavioral changes indicating altered resilience against psychiatric disorders. These could be reversed by modulation of phospholipid signaling via pharmacological inhibition of the LPA‐synthesizing molecule autotaxin. In line, EEG recordings in a human population‐based cohort revealed an E/I balance shift in monoallelic mutPRG‐1 carriers and an impaired sensory gating, which is regarded as an endophenotype of stress‐related mental disorders. Intervention into bioactive lipid signaling is thus a promising strategy to interfere with glutamate‐dependent symptoms in psychiatric diseases
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