Defining the causes of sporadic Parkinson's disease in the global Parkinson's genetics program (GP2)

The Global Parkinson's Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.This research is supported by the Aligning Science Across Parkinson’s Initiative, the Intramural Research Program, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, project ZO1 AG000949, and the Michael J. Fox Foundation for Parkinson’s Research. Data used in the preparation of this article were obtained from Global Parkinson’s Genetics Program (GP2). GP2 is funded by the Aligning Science Across Parkinson’s (ASAP) initiative and implemented by The Michael J. Fox Foundation for Parkinson’s Research (https://gp2.org). For a complete list of GP2 members see https://gp2.org.Peer reviewe

Defining the causes of sporadic Parkinson's disease in the global Parkinson's genetics program (GP2)

The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia

A new multistakeholder cooperative formula: the social cooperative

El modelo cooperativo tradicional está basado en un solo tipo de miembros: usuarios, productores o trabajadores. Pero recientemente, han surgido otras fórmulas cooperativas, en respuesta a nuevas necesidades sociales, en particular en el campo de los servicios sociales y del desarrollo local y sustentable. Estas cooperativas integran diferentes categorías de miembros: usuarios, trabajadores, voluntarios, organismos de apoyo. En este artículo se describen tres casos de cooperativas sociales: las Cooperativas Sociales italianas, las Cooperativas de Solidaridad en Québec y las Sociedades Cooperativas de Interés Colectivo francesas. Se presenta su proceso de emergencia, las nuevas leyes que regulan estas cooperativas, los principales sectores de actividad en que se han desarrollado. Se destaca su contribución al desarrollo económico y [email protected] traditionnal co-operative model is based on uniform membership: consumers, producers or workers. But recently, new co-operative formulas have emerged, to respond new social needs, particularly in social services and local and sustainable development. The social co-operatives are multistakeholders co-operatives, formed by different categories of members. This article describes three cases of social cooperatives (social co-operatives in Italy, solidarity co-operatives in Quebec, collective interest cooperative society in France). It presents the process of their creation, the principal dimensions of the laws that regulate them, their principal sectors of activity, and briefly analyses their contribution to economic and social development

An innovative formula for access to housing: housing co-operatives in Uruguay

En Uruguay las cooperativas de vivienda representan un actor importante en el campo de la construcción residencial, y un aporte original a la solución del problema del acceso a la vivienda para las clases populares. Surgido en la década 1960, el movimiento cooperativo ha construido miles de viviendas para las familias de los sectores populares. También se ha constituido en un importante movimiento social, con la creación de federaciones nacionales. En este artículo se analizan las principales características del modelo uruguayo de cooperativas de vivienda: su contexto de emergencia, su evolución, y se analizan los principales factores de su é[email protected] Uruguay, the housing co-operatives represent an important actor in the field of housing, and it has made a significant contribution to solve the problem of the access of low or middlelow income families to a decent dwelling. It has built thousands of houses since su creation in the sixties. Il has become a strong social movement, with the founding of nacional federations of housing co-operatives. In this paper, we analyze the principal characteristics of the uruguayan model of housing co-operatives, the context of its emergence, its evolution, and the principal reasons of its success

The day-care centers in Quebec: from the experimentation to the institutionalization

En las sociedades modernas, la incorporación de las mujeres al mercado de trabajo genera una nueva necesidad de socialización de los servicios de atención a lo niños. Existen diversos modelos de respuesta a esta necesidad en las diferentes sociedades. Este artículo presenta el caso de la provincia de Quebec, en Canadá. Describe el proceso de emergencia de guarderías autogestionarias, creadas por grupos de usuarios, y las diferentes etapas de la lucha de un movimiento social que han llevado a un reconocimiento por el Estado de estas iniciativas. Se describen brevemente la estructura y el funcionamiento de estas guarderías administradas por sus usuarios, con participación de su personal, y financiamiento público. En una tercera parte, se presentan diversas perspectivas de análisis sobre los CPE a partir de la revisión de algunos estudios [email protected] analíticoSemestralIn the modern societies, the incorporation of the women to the labor market generates a new need of socialization of the services of attention to children. Diverse models of response exist to this need in the different societies. This article presents the case of the province of Quebec, in Canada. It describes the emergency process of day-care centers autogestionarias, created by user groups, and the different stages of the fight of a social movement that have led to a recognition for the State of these initiatives. There are described brief the structure and the functioning of these day-care centers administered by his users, with participation of his personnel, and public financing. In a third part, they present diverse perspectives of analysis on the CPE from the review of some studies quebequenses

Movimientos sociales e innovaciones en los intercambios comerciales.

Presentación.Movimientos sociales e innovaciones en los intercambios comerciales.Richer, MadeleineArtículosEl papel de los consumidores en el fortalecimiento de la economía plural: el caso de las asociaciones de consumidores de productos orgánicos en el sur de Brasil.The role of consumers in strengthening the plural economy: the case of organic products consumers Associations in the South of Brasil.Serva, Mauricio y Andion, CarolinaCartografía de un proyecto de comercio justo en el sur: la central Interregional de artesanos de Perú.Cartography of a fair trade project in the south: la central interregional de artesanos de Perú.Lemay, Jean FrédéricLas organizaciones del ámbito asociativo en la formación de capital social.The associative organizations in the formation of social capital.Saz Gil, María Isabel y Sajardo Moreno, AntoniaLa economía social en España: ¿qué es y como está conformada?Social economy in spain. What it is and how it is structured?Pereira Morais, LeandroReseñaPonce, Yolanda: Cooperativas y reforma económica: el caso de las cooperativas ribereñas de camarón en Sinaloa.Reseña: Argüello, LeonardoBornstein, David: el precio de un sueño. La aventura de Muhammad Yunus y el Grameen Bank.Reseña: Richer, [email protected] analíticosemestra

Vargas Recicla: la inserción social y laboral combinada con el reciclaje de desechos.

PresentaciónDossier: La economía social en Brasil (primera parte)ArtículosPor uma visão positiva da sociedade civil: uma análise histórica da sociedade civil organizada no Brasil.Andion, CarolinaServa, MauricioCapital Social e Capital Social e Resíduos Sólidos: Organizações e Multissetorialismo em Florianópolis- SC.Boeira, Sérgio Luisda Silva , Wanessa CéliaSustentabilidade Social de uma Organização de Economia Social: um estudo de caso na AFECE - Associação Franciscana de Educação ao Cidadão Especial.Moraes Pinheiro, DanielCapital social. Su potencial para el análisis integral sociopolítico.Govea, HectorRodrígues Colmenares, IsabelLa experiencia cooperativa en la cría de ovinos y caprinos en la Guajira venezolana.Fuenmayor, Nila del CarmenGamboa Cáceres, TeresaAcurero Abreu, LucreciaExperienciasVargas Recicla: la inserción social y laboral combinada con el reciclaje de desechos.Richer, MadeleineReseñaHugo Cerda Gutiérrez, Carlos Julio Pineda El cooperativismo colombiano después de la crisis.Reseñado por: Melgarejo, Maritza y Alvarez, Juan FernandoEventosEventos:CIRIEC-Venezuela: V Simposio de Economía Social25 Congreso internacional del [email protected] analíticosemestra

Lopez Maya, Margarita (editora): ideas para debatir el socialismo del siglo XXI

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