The One-Loop H^2R^3 and H^2(DH)^2R Terms in the Effective Action

We consider the one-loop B^2h^3 and B^4h amplitudes in type II string theory, where B is the NS-NS two-form and h the graviton, and expand to lowest order in alpha'. After subtracting diagrams due to quartic terms in the effective action, we determine the presence and structure of both an H^2R^3 and H^2(DH)^2R term. We show that both terms are multiplied by the usual (t_8t_8\pm{1/8}\epsilon_{10}\epsilon_{10}) factor.Comment: 20 pages, 3 figures; corrected typo

Target shape dependence in a simple model of receptor-mediated endocytosis and phagocytosis

Phagocytosis and receptor-mediated endocytosis are vitally important particle uptake mechanisms in many cell types, ranging from single-cell organisms to immune cells. In both processes, engulfment by the cell depends critically on both particle shape and orientation. However, most previous theoretical work has focused only on spherical particles and hence disregards the wide-ranging particle shapes occurring in nature, such as those of bacteria. Here, by implementing a simple model in one and two dimensions, we compare and contrast receptor-mediated endocytosis and phagocytosis for a range of biologically relevant shapes, including spheres, ellipsoids, capped cylinders, and hourglasses. We find a whole range of different engulfment behaviors with some ellipsoids engulfing faster than spheres, and that phagocytosis is able to engulf a greater range of target shapes than other types of endocytosis. Further, the 2D model can explain why some nonspherical particles engulf fastest (not at all) when presented to the membrane tip-first (lying flat). Our work reveals how some bacteria may avoid being internalized simply because of their shape, and suggests shapes for optimal drug delivery.Comment: 18 pages, 5 figure