The Hydrogendifluoride Anion in an Asymmetric Crystalline Environment: The Crystal and Molecular Structure of Trithioureatellurium(II) Di(Hydrogendifluoride)

The crystal structure of Te[CS(NH2l2h(FHF)2, I , was determined at 133K using single crystal x-ray diffraction techniques. A total of 6042 independent reflections were observed for the monoclinic crystals (space group P21/c, No. 14, a = 0.5846(3), b = 2.046(1), c = 1.1433(7) nm, (J = 94.69(5) 0 , Ve= 1.363(1) nm3, (Z = 4), in the range 4.0° s 219 s 70.0° of which 5243 had F0 2 > 3a (F0 2). The trithiourea- tellurium (II) molecules crystallize as dimeric distorted square planar cations [Te(tu)3]24+ (tu = thiourea) located about an inversion center. The cations are linked by N-H ... F hydrogen bonds. The environment about the two independent (FHFt anions is decidedly asymmetric and therefore the hydrogen atoms are not centered between the fluorine atoms

Evidence for constriction and Pliocene acceleration of east-west extension in the North Lunggar rift region of west central Tibet

This is the publisher's version, also available electronically from http://onlinelibrary.wiley.com/doi/10.1002/tect.20086/abstract;jsessionid=36D445F6B0A54FA5B74E359605FC0AD1.f04t02The active north trending North Lunggar rift in west central southern Tibet exposes an extensional metamorphic core complex bounded by an east dipping low-angle normal fault. Apatite and zircon (U-Th)/He thermochronology and thermal modeling of the North Lunggar rift document a minimum timing for rift inception at >10 Ma and rapid footwall exhumation between 5 and 2 Ma. Miocene footwall cooling and exhumation rates were initially slow to moderate at 400°C Ma−1 and 4–10 mm a−1. Footwall isotherms were significantly compressed during rapid exhumation resulting in an elevated transient geothermal gradient between 50 and 90°C km−1. The minimum magnitude of horizontal extension for the North Lunggar rift is 8.1–12.8 km; maximum is 15–20 km, less in the south at ~10 km. Mean Pliocene extension rate is 1.2–2.4 mm a−1 in the ~120° direction. Results for the North Lunggar rift are similar in magnitude, rate, and orientation of slip to the kinematically linked Lamu Co dextral strike-slip fault to the north. This suggests a state of constrictional strain during Pliocene time along this stretch of the Bangong-Nujiang suture from which the Lamu Co fault emanates. The onset of extension in this region may be explained by crustal thickening and gravitational orogenic collapse, followed by accelerated rifting resulting from localized crustal stretching and increased magmatic activity, potentially driven by the position and northward extent of underthrusting Indian lithosphere

Miocene initiation and acceleration of extension in the South Lunggar rift, western Tibet: Evolution of an active detachment system from structural mapping and (U-Th)/He thermochronology

This is the publisher's version, also available electronically from http://onlinelibrary.wiley.com/doi/10.1002/tect.20053/abstractOngoing extension in Tibet may have begun in the middle to late Miocene, but there are few robust estimates of the rates, timing, or magnitude of Neogene deformation within the Tibetan plateau. We present a comprehensive study of the seismically active South Lunggar rift in southwestern Tibet incorporating mapping, U-Pb geochronology and zircon (U-Th)/He thermochronology. The South Lunggar rift is the southern continuation of the North Lunggar rift and comprises a ~50 km N-S central horst bound by two major normal faults, the west-dipping South Lunggar detachment and the east-dipping Palung Co fault. The SLD dips at the rangefront ~20°W and exhumes a well-developed mylonite zone in its footwall displaying fabrics indicative of normal-sense shear. The range is composed of felsic orthogneiss, mafic amphibolite, and leucogranite intrusions dated at ~16 and 63 Ma. Zircon (U-Th)/He cooling ages are Oligocene through late Pliocene, with the youngest ages observed in the footwall of the SLD. We tested ~25,000 unique thermokinematic forward models in Pecube against the structural and (U-Th)/He data to fully bracket the allowable ranges in fault initiations, accelerations, and slip rates. We find that normal faulting in the SLR began in the middle Miocene with horizontal extension rates of ~1 mm a−1, and in the north accelerated at 8 Ma to 2.5–3.0 mm a−1 as faulting commenced on the SLD. Cumulative horizontal extension across the SLR ranges from <10 km in the south to 19–21 km in the north

Cognitive Impairment Precedes and Predicts Functional Impairment in Mild Alzheimer’s Disease

Abstract Background: The temporal relationship of cognitive deficit and functional impairment in Alzheimer’s disease (AD) is not well characterized. Recent analyses suggest cognitive decline predicts subsequent functional decline throughout AD progression. Objective: To better understand the relationship between cognitive and functional decline in mild AD using autoregressive cross-lagged (ARCL) panel analyses in several clinical trials. Methods: Data included placebo patients with mild AD pooled from two multicenter, double-blind, Phase 3 solanezumab (EXPEDITION/2) or semagacestat (IDENTITY/2) studies, and from AD patients participating in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Cognitive and functional outcomes were assessed using AD Assessment Scale-Cognitive subscale (ADAS-Cog), AD Cooperative Study-Activities of Daily Living instrumental subscale (ADCS-iADL), or Functional Activities Questionnaire (FAQ), respectively. ARCL panel analyses evaluated relationships between cognitive and functional impairment over time. Results: In EXPEDITION, ARCL panel analyses demonstrated cognitive scores significantly predicted future functional impairment at 5 of 6 time points, while functional scores predicted subsequent cognitive scores in only 1 of 6 time points. Data from IDENTITY and ADNI programs yielded consistent results whereby cognition predicted subsequent function, but not vice-versa. Conclusions: Analyses from three databases indicated cognitive decline precedes and predicts subsequent functional decline in mild AD dementia, consistent with previously proposed hypotheses, and corroborate recent publications using similar methodologies. Cognitive impairment may be used as a predictor of future functional impairment in mild AD dementia and can be considered a critical target for prevention strategies to limit future functional decline in the dementia process

Evaluating the Shinumo-Sespe drainage connection: Arguments against the “old” (70–17 Ma) Grand Canyon models for Colorado Plateau drainage evolution

The provocative hypothesis that the Shinumo Sandstone in the depths of Grand Canyon was the source for clasts of orthoquartzite in conglomerate of the Sespe Formation of coastal California, if verified, would indicate that a major river system flowed southwest from the Colorado Plateau to the Pacific Ocean prior to opening of the Gulf of California, and would imply that Grand Canyon had been carved to within a few hundred meters of its modern depth at the time of this drainage connection. The proposed Eocene Shinumo-Sespe connection, however, is not supported by detrital zircon nor paleomagnetic-inclination data and is refuted by thermochronology that shows that the Shinumo Sandstone of eastern Grand Canyon was \u3e60 °C (∼1.8 km deep) and hence not incised at this time. A proposed 20 Ma (Miocene) Shinumo-Sespe drainage connection based on clasts in the Sespe Formation is also refuted. We point out numerous caveats and non-unique interpretations of paleomagnetic data from clasts. Further, our detrital zircon analysis requires diverse sources for Sespe clasts, with better statistical matches for the four “most-Shinumo-like” Sespe clasts with quartzites of the Big Bear Group and Ontario Ridge metasedimentary succession of the Transverse Ranges, Horse Thief Springs Formation from Death Valley, and Troy Quartzite of central Arizona. Diverse thermochronologic and geologic data also refute a Miocene river pathway through western Grand Canyon and Grand Wash trough. Thus, Sespe clasts do not require a drainage connection from Grand Canyon or the Colorado Plateau and provide no constraints for the history of carving of Grand Canyon. Instead, abundant evidence refutes the “old” (70–17 Ma) Grand Canyon models and supports a \u3c6 Ma Grand Canyon

Predicting risk of cardiovascular events 1 to 3 years post-myocardial infarction using a global registry.

BACKGROUND: Risk prediction tools are lacking for patients with stable disease some years after myocardial infarction (MI). HYPOTHESIS: A practical long-term cardiovascular risk index can be developed. METHODS: The long-Term rIsk, Clinical manaGement and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients prospective global registry enrolled patients 1 to 3 years post-MI (369 centers; 25 countries), all with ≥1 risk factor (age ≥65 years, diabetes mellitus requiring medication, second prior MI, multivessel coronary artery disease, or chronic non-end-stage kidney disease [CKD]). Self-reported health was assessed with EuroQoL-5 dimensions. Multivariable Poisson regression models were used to determine key predictors of the primary composite outcome (MI, unstable angina with urgent revascularization [UA], stroke, or all-cause death) over 2 years. RESULTS: The primary outcome occurred in 621 (6.9%) of 9027 eligible patients: death 295 (3.3%), MI 195 (2.2%), UA 103 (1.1%), and stroke 58 (0.6%). All events accrued linearly. In a multivariable model, 11 significant predictors of primary outcome (age ≥65 years, diabetes, second prior MI, CKD, history of major bleed, peripheral arterial disease, heart failure, cardiovascular hospitalization (prior 6 months), medical management (index MI), on diuretic, and poor self-reported health) were identified and combined into a user-friendly risk index. Compared with lowest-risk patients, those in the top 16% had a rate ratio of 6.9 for the primary composite, and 18.7 for all-cause death (overall c-statistic; 0.686, and 0.768, respectively). External validation was performed using the Australian Cooperative National Registry of Acute Coronary Care, Guideline Adherence and Clinical Events registry (c-statistic; 0.748, and 0.849, respectively). CONCLUSIONS: In patients >1-year post-MI, recurrent cardiovascular events and deaths accrue linearly. A simple risk index can stratify patients, potentially helping to guide management

How predation and landscape fragmentation affect vole population dynamics

Background: Microtine species in Fennoscandia display a distinct north-south gradient from regular cycles to stable populations. The gradient has often been attributed to changes in the interactions between microtines and their predators. Although the spatial structure of the environment is known to influence predator-prey dynamics of a wide range of species, it has scarcely been considered in relation to the Fennoscandian gradient. Furthermore, the length of microtine breeding season also displays a north-south gradient. However, little consideration has been given to its role in shaping or generating population cycles. Because these factors covary along the gradient it is difficult to distinguish their effects experimentally in the field. The distinction is here attempted using realistic agent-based modelling. Methodology/Principal Findings: By using a spatially explicit computer simulation model based on behavioural and ecological data from the field vole (Microtus agrestis), we generated a number of repeated time series of vole densities whose mean population size and amplitude were measured. Subsequently, these time series were subjected to statistical autoregressive modelling, to investigate the effects on vole population dynamics of making predators more specialised, of altering the breeding season, and increasing the level of habitat fragmentation. We found that fragmentation as well as the presence of specialist predators are necessary for the occurrence of population cycles. Habitat fragmentation and predator assembly jointly determined cycle length and amplitude. Length of vole breeding season had little impact on the oscillations. Significance: There is good agreement between our results and the experimental work from Fennoscandia, but our results allow distinction of causation that is hard to unravel in field experiments. We hope our results will help understand the reasons for cycle gradients observed in other areas. Our results clearly demonstrate the importance of landscape fragmentation for population cycling and we recommend that the degree of fragmentation be more fully considered in future analyses of vole dynamics

Health-related quality of life 1–3 years post-myocardial infarction: its impact on prognosis

ObjectiveTo assess associations of health-related quality of life (HRQoL) with patient profile, resource use, cardiovascular (CV) events and mortality in stable patients post-myocardial infarction (MI).MethodsThe global, prospective, observational TIGRIS Study enrolled 9126 patients 1–3 years post-MI. HRQoL was assessed at enrolment and 6-month intervals using the patient-reported EuroQol-5 dimension (EQ-5D) questionnaire, with scores anchored at 0 (worst possible) and 1 (perfect health). Resource use, CV events and mortality were recorded during 2-years’ follow-up. Regression models estimated the associations of index score at enrolment with patient characteristics, resource use, CV events and mortality over 2-years’ follow-up.ResultsAmong 8978 patients who completed the EQ-5D questionnaire, 52% reported ‘some’ or ‘severe’ problems on one or more health dimensions. Factors associated with a lower index score were: female sex, older age, obesity, smoking, higher heart rate, less formal education, presence of comorbidity (eg, angina, stroke), emergency room visit in the previous 6 months and non-ST-elevation MI as the index event. Compared with an index score of 1 at enrolment, a lower index score was associated with higher risk of all-cause death, with an adjusted rate ratio of 3.09 (95% CI 2.20 to 4.31), and of a CV event, with a rate ratio of 2.31 (95% CI 1.76 to 3.03). Patients with lower index score at enrolment had almost two times as many hospitalisations over 2-years’ follow-up.ConclusionsClinicians managing patients post-acute coronary syndrome should recognise that a poorer HRQoL is clearly linked to risk of hospitalisations, major CV events and death.Trial registration numberClinicalTrials.gov Registry (NCT01866904) (https://clinicaltrials.gov).</jats:sec

Two-year outcomes among stable high-risk patients following acute MI. Insights from a global registry in 25 countries.

BACKGROUND: Evidence is lacking on long-term outcomes in unselected patients surviving the first year following myocardial infarction (MI). METHODS AND RESULTS: The TIGRIS (long-Term rIsk, clinical manaGement and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients) prospective registry enrolled 9176 eligible patients aged ≥50 years, 1-3 years post-MI, from 25 countries. All had ≥1 risk factor: age ≥ 65 years, diabetes mellitus, second prior MI, multivessel coronary artery disease, chronic kidney disease (CKD). Primary outcome was a composite of MI, unstable angina with urgent revascularization, stroke, or all-cause death at 2-year follow-up. Bleeding requiring hospitalization was also recorded. 9027 patients (98.4%) provided follow-up data: the primary outcome occurred in 621 (7.0%), all-cause mortality in 295 (3.3%), and bleeding in 109 (1.2%) patients. Events accrued linearly over time. In multivariable analyses, qualifying risk factors were associated with increased risk of primary outcome (incidence rate ratio [RR] per 100 patient-years [95% confidence interval]): CKD 2.06 (1.66, 2.55), second prior MI 1.71 (1.38, 2.10), diabetes mellitus 1.63 (1.39, 1.92), age ≥ 65 years 1.53 (1.28, 1.83), and multivessel disease 1.24 (1.05, 1.48). Risk of bleeding events was greater in older patients (vs <65 years) 65-74 years 2.68 (1.53, 4.70), ≥75 years 4.62 (2.57, 8.28), and those with CKD 1.99 (1.18, 3.35). CONCLUSION: In stable patients recruited 1-3 years post-MI, recurrent cardiovascular and bleeding events accrued linearly over 2 years. Factors independently predictive of ischemic and bleeding events were identified, providing a context for deciding on treatment options

Vilhelm Lundstedt’s ‘Legal Machinery’ and the Demise of Juristic Practice

This article aims to contribute to the academic debate on the general crisis faced by law schools and the legal professions by discussing why juristic practice is a matter of experience rather than knowledge. Through a critical contextualisation of Vilhelm Lundstedt’s thought under processes of globalisation and transnationalism, it is argued that the demise of the jurist’s function is related to law’s scientification as brought about by the metaphysical construction of reality. The suggested roadmap will in turn reveal that the current voiding of juristic practice and its teaching is part of the crisis regarding what makes us human